Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension
Fruit extracts of different strawberry cultivars were evaluated for their potential to contribute to the dietary management of hyperglycemia-linked to type 2 diabetes and related hypertension. In vitro inhibition of α-amylase, α-glucosidase, and angiotensin-1-converting enzyme (ACE) activity was eva...
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| Veröffentlicht in: | Bioresource technology 2010, Vol.101 (1), p.404-413 |
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| creator | Cheplick, Susan Kwon, Young-In Bhowmik, Prasanta Shetty, Kalidas |
| description | Fruit extracts of different strawberry cultivars were evaluated for their potential to contribute to the dietary management of hyperglycemia-linked to type 2 diabetes and related hypertension.
In vitro inhibition of α-amylase, α-glucosidase, and angiotensin-1-converting enzyme (ACE) activity was evaluated using fruit extracts and correlated to phenolic content and antioxidant activity. There were significant differences between cultivars in both phenolic-linked antioxidant activity and inhibitory activity for the targeted disease relevant enzymes. Honeoye, Idea, and Jewel cultivars exhibited moderate α-amylase inhibition. Strawberry cultivars, in general, exhibited uniform α-glucosidase inhibition with Ovation having the highest inhibitory activity. Water extracts of Jewel and Ovation cultivars had moderate ACE inhibition compared to low inhibition observed in other cultivars. Strawberry cultivars with combined inhibitory potential against α-glucosidase and ACE and with moderate or low α-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension. |
| doi_str_mv | 10.1016/j.biortech.2009.07.068 |
| format | Article |
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In vitro inhibition of α-amylase, α-glucosidase, and angiotensin-1-converting enzyme (ACE) activity was evaluated using fruit extracts and correlated to phenolic content and antioxidant activity. There were significant differences between cultivars in both phenolic-linked antioxidant activity and inhibitory activity for the targeted disease relevant enzymes. Honeoye, Idea, and Jewel cultivars exhibited moderate α-amylase inhibition. Strawberry cultivars, in general, exhibited uniform α-glucosidase inhibition with Ovation having the highest inhibitory activity. Water extracts of Jewel and Ovation cultivars had moderate ACE inhibition compared to low inhibition observed in other cultivars. Strawberry cultivars with combined inhibitory potential against α-glucosidase and ACE and with moderate or low α-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension.</description><identifier>ISSN: 0960-8524</identifier><identifier>EISSN: 1873-2976</identifier><identifier>DOI: 10.1016/j.biortech.2009.07.068</identifier><identifier>PMID: 19695871</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>alpha-amylase ; alpha-glucosidase ; antioxidant activity ; complications ; diet therapy ; enzyme inhibition ; Enzyme inhibitors ; Fragaria ; Fragaria - chemistry ; Humans ; Hyperglycemia ; Hyperglycemia - diet therapy ; Hypertension ; Hypertension - complications ; Hypertension - diet therapy ; noninsulin-dependent diabetes mellitus ; peptidyl-dipeptidase A ; phenolic compounds ; Phenolics ; Phenols - analysis ; Phenols - metabolism ; Phenols - therapeutic use ; Phytotherapy - methods ; Plant Extracts - analysis ; Plant Extracts - chemistry ; strawberries ; Strawberry cultivars</subject><ispartof>Bioresource technology, 2010, Vol.101 (1), p.404-413</ispartof><rights>2009 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-b73e18bf14bb87c6a3a4dcf6015debe80ef79d1d5ed01e82188f83a0cdaebe143</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biortech.2009.07.068$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19695871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheplick, Susan</creatorcontrib><creatorcontrib>Kwon, Young-In</creatorcontrib><creatorcontrib>Bhowmik, Prasanta</creatorcontrib><creatorcontrib>Shetty, Kalidas</creatorcontrib><title>Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension</title><title>Bioresource technology</title><addtitle>Bioresour Technol</addtitle><description>Fruit extracts of different strawberry cultivars were evaluated for their potential to contribute to the dietary management of hyperglycemia-linked to type 2 diabetes and related hypertension.
In vitro inhibition of α-amylase, α-glucosidase, and angiotensin-1-converting enzyme (ACE) activity was evaluated using fruit extracts and correlated to phenolic content and antioxidant activity. There were significant differences between cultivars in both phenolic-linked antioxidant activity and inhibitory activity for the targeted disease relevant enzymes. Honeoye, Idea, and Jewel cultivars exhibited moderate α-amylase inhibition. Strawberry cultivars, in general, exhibited uniform α-glucosidase inhibition with Ovation having the highest inhibitory activity. Water extracts of Jewel and Ovation cultivars had moderate ACE inhibition compared to low inhibition observed in other cultivars. Strawberry cultivars with combined inhibitory potential against α-glucosidase and ACE and with moderate or low α-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension.</description><subject>alpha-amylase</subject><subject>alpha-glucosidase</subject><subject>antioxidant activity</subject><subject>complications</subject><subject>diet therapy</subject><subject>enzyme inhibition</subject><subject>Enzyme inhibitors</subject><subject>Fragaria</subject><subject>Fragaria - chemistry</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Hyperglycemia - diet therapy</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - diet therapy</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>peptidyl-dipeptidase A</subject><subject>phenolic compounds</subject><subject>Phenolics</subject><subject>Phenols - analysis</subject><subject>Phenols - metabolism</subject><subject>Phenols - therapeutic use</subject><subject>Phytotherapy - methods</subject><subject>Plant Extracts - analysis</subject><subject>Plant Extracts - chemistry</subject><subject>strawberries</subject><subject>Strawberry cultivars</subject><issn>0960-8524</issn><issn>1873-2976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OEzEQhC0EYsPCKyw-wWmG7vmz5wZaLT_SSiDBni2P3ZM4zIyD7SzKQ_DOOCTADU6Wur6usroYu0IoEbB7tS0H50MisykrgL4EUUInH7AVSlEXVS-6h2wFfQeFbKvmgj2JcQsANYrqMbvAvutbKXDFfnza0OInZ4rJLV_J8nsdnE7OL9wtPKagvw8UwoGb_ZRcFiMffeA7n2hJTk_cOko667Ne9JrmPOV-5JvDjsJ6OhianeZ6sTzQpFP2N37e5bhfEfEPmt1iHjxlj0Y9RXp2fi_Z3dubL9fvi9uP7z5cv7ktTCNlKgZRE8phxGYYpDCdrnVjzdgBtpYGkkCj6C3aliwgyQqlHGWtwVidZWzqS_by5LsL_tueYlKzi4amSS_k91GJuoG27vs-ky_-SVaI0DYoM9idQBN8jIFGtQtuzpdRCOpYmdqq35WpY2UKhMqV5cWrc8J-mMn-XTt3lIHnJ2DUXul1cFHdfa4A62wqG5BH4vWJoHyze0dBReNoMWRdIJOU9e5_v_gJrEq6Jg</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Cheplick, Susan</creator><creator>Kwon, Young-In</creator><creator>Bhowmik, Prasanta</creator><creator>Shetty, Kalidas</creator><general>Elsevier Ltd</general><general>[New York, NY]: Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7ST</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension</title><author>Cheplick, Susan ; Kwon, Young-In ; Bhowmik, Prasanta ; Shetty, Kalidas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-b73e18bf14bb87c6a3a4dcf6015debe80ef79d1d5ed01e82188f83a0cdaebe143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>alpha-amylase</topic><topic>alpha-glucosidase</topic><topic>antioxidant activity</topic><topic>complications</topic><topic>diet therapy</topic><topic>enzyme inhibition</topic><topic>Enzyme inhibitors</topic><topic>Fragaria</topic><topic>Fragaria - chemistry</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Hyperglycemia - diet therapy</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - diet therapy</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>peptidyl-dipeptidase A</topic><topic>phenolic compounds</topic><topic>Phenolics</topic><topic>Phenols - analysis</topic><topic>Phenols - metabolism</topic><topic>Phenols - therapeutic use</topic><topic>Phytotherapy - methods</topic><topic>Plant Extracts - analysis</topic><topic>Plant Extracts - chemistry</topic><topic>strawberries</topic><topic>Strawberry cultivars</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheplick, Susan</creatorcontrib><creatorcontrib>Kwon, Young-In</creatorcontrib><creatorcontrib>Bhowmik, Prasanta</creatorcontrib><creatorcontrib>Shetty, Kalidas</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioresource technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheplick, Susan</au><au>Kwon, Young-In</au><au>Bhowmik, Prasanta</au><au>Shetty, Kalidas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension</atitle><jtitle>Bioresource technology</jtitle><addtitle>Bioresour Technol</addtitle><date>2010</date><risdate>2010</risdate><volume>101</volume><issue>1</issue><spage>404</spage><epage>413</epage><pages>404-413</pages><issn>0960-8524</issn><eissn>1873-2976</eissn><abstract>Fruit extracts of different strawberry cultivars were evaluated for their potential to contribute to the dietary management of hyperglycemia-linked to type 2 diabetes and related hypertension.
In vitro inhibition of α-amylase, α-glucosidase, and angiotensin-1-converting enzyme (ACE) activity was evaluated using fruit extracts and correlated to phenolic content and antioxidant activity. There were significant differences between cultivars in both phenolic-linked antioxidant activity and inhibitory activity for the targeted disease relevant enzymes. Honeoye, Idea, and Jewel cultivars exhibited moderate α-amylase inhibition. Strawberry cultivars, in general, exhibited uniform α-glucosidase inhibition with Ovation having the highest inhibitory activity. Water extracts of Jewel and Ovation cultivars had moderate ACE inhibition compared to low inhibition observed in other cultivars. Strawberry cultivars with combined inhibitory potential against α-glucosidase and ACE and with moderate or low α-amylase inhibitory potential could be targeted for potential management of hyperglycemia-linked type 2 diabetes and related complication of hypertension.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19695871</pmid><doi>10.1016/j.biortech.2009.07.068</doi><tpages>10</tpages></addata></record> |
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| subjects | alpha-amylase alpha-glucosidase antioxidant activity complications diet therapy enzyme inhibition Enzyme inhibitors Fragaria Fragaria - chemistry Humans Hyperglycemia Hyperglycemia - diet therapy Hypertension Hypertension - complications Hypertension - diet therapy noninsulin-dependent diabetes mellitus peptidyl-dipeptidase A phenolic compounds Phenolics Phenols - analysis Phenols - metabolism Phenols - therapeutic use Phytotherapy - methods Plant Extracts - analysis Plant Extracts - chemistry strawberries Strawberry cultivars |
| title | Phenolic-linked variation in strawberry cultivars for potential dietary management of hyperglycemia and related complications of hypertension |
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