Modulation of bile acid metabolism by 1alpha-hydroxyvitamin D3 administration in mice

The vitamin D receptor (VDR) is a nuclear receptor for the active form of vitamin D(3) and mediates regulation of calcium homeostasis. Bile acids, such as lithocholic acid, have been identified as additional endogenous VDR ligands. The in vivo role of VDR in bile acid metabolism has not been elucida...

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Veröffentlicht in:	Drug metabolism and disposition 2009-10, Vol.37 (10), p.2037-2044
Hauptverfasser:	Nishida, Shigeru, Ozeki, Jun, Makishima, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D3 1-alpha-Hydroxylase Animals Bile Acids and Salts - metabolism Biological Transport - drug effects Biological Transport - physiology Cell Line Cell Line, Tumor Chenodeoxycholic Acid - pharmacology Cholecalciferol - pharmacology Cholic Acid - pharmacology Homeostasis - drug effects Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Male Mice Mice, Inbred C57BL Multidrug Resistance-Associated Proteins Receptors, Calcitriol - metabolism RNA, Messenger - metabolism
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