11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma: comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness
Background To determine the usefulness of positron emission tomography (PET) with 11 C-acetate (AC) for imaging lung adenocarcinoma and evaluating its tumor aggressiveness, AC- and 18 F-fluorodeoxyglucose (FDG)-PET were compared. Methods One hundred and sixty-nine adenocarcinomas with clinical stage...
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| Veröffentlicht in: | Annals of nuclear medicine 2009-09, Vol.23 (7), p.609-616 |
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| creator | Shibata, Hidekatsu Nomori, Hiroaki Uno, Kimiichi Iyama, Ken-ichi Tomiyoshi, Katsumi Nakashima, Rumi Sakaguchi, Kazuya Goya, Tomoyuki Takanami, Iwao Koizumi, Kiyoshi Suzuki, Takashi Kaji, Masahiro Horio, Hirotoshi |
| description | Background
To determine the usefulness of positron emission tomography (PET) with
11
C-acetate (AC) for imaging lung adenocarcinoma and evaluating its tumor aggressiveness, AC- and
18
F-fluorodeoxyglucose (FDG)-PET were compared.
Methods
One hundred and sixty-nine adenocarcinomas with clinical stage IA and 53 benign nodules were examined by both AC- and FDG-PET before surgery. The sensitivity and specificity for discriminating benign/adenocarcinoma were compared between AC- and FDG-PET. The AC and FDG uptakes were examined to determine the relationship with tumor aggressiveness, i.e., pathological tumor stage, lymphatic, vascular, or pleural involvement, and proliferative activity determined by Ki-67 staining score.
Results
While the sensitivity of AC-PET was significantly higher than FDG-PET for bronchioloalveolar carcinoma (BAC) and well-differentiated (W/D) adenocarcinoma (
p
|
| doi_str_mv | 10.1007/s12149-009-0278-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734052398</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1895464461</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2399-1a143f043c73bd8d4a574d1fb7df400aba5441181614b8d532fd2feed5fe11bd3</originalsourceid><addsrcrecordid>eNp1kc9u1DAQxiMEokvhAbggiwungMd2EodbtaJQqRIXOFsT_0ldJfZiJ4V9Mx4Pr7KoEhIHayzNb75v7K-qXgN9D5R2HzIwEH1NaTmsk3X_pNqBbEXdCs6fVjvag6g7kN1F9SLne0qZbCR7Xl1A37RMcLmrfgPsa9R2wcUSFxM5xOyXFAOxs8_Zl8sS5zgmPNwdiZ9x9GEk0RE9-eA1TiQvOFpyc0WmtXTQ2BA1Ju1DnPEj0XE-YPK56Pz0yx0BeV27aY0pGht_Hcdp1TFvzn_FMRhiH3BacTnZF69lnUsfxzHZstKDDaW8rJ45nLJ9da6X1ffrT9_2X-rbr59v9le3tWa872tAENxRwXXHByONwKYTBtzQGScoxQEbIQAktCAGaRrOnGHOWtM4CzAYflm923QPKf5YbV5U-RdtpwmDjWtWHRe0KVaykG__Ie_jmkJZTjFoqOh42xQINkinmHOyTh1SeXg6KqDqFKraQlUlVHUKVfVl5s1ZeB1max4nzikWgG1ALq0w2vTo_H_VPxfRsPM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>215047365</pqid></control><display><type>article</type><title>11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma: comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Shibata, Hidekatsu ; Nomori, Hiroaki ; Uno, Kimiichi ; Iyama, Ken-ichi ; Tomiyoshi, Katsumi ; Nakashima, Rumi ; Sakaguchi, Kazuya ; Goya, Tomoyuki ; Takanami, Iwao ; Koizumi, Kiyoshi ; Suzuki, Takashi ; Kaji, Masahiro ; Horio, Hirotoshi</creator><creatorcontrib>Shibata, Hidekatsu ; Nomori, Hiroaki ; Uno, Kimiichi ; Iyama, Ken-ichi ; Tomiyoshi, Katsumi ; Nakashima, Rumi ; Sakaguchi, Kazuya ; Goya, Tomoyuki ; Takanami, Iwao ; Koizumi, Kiyoshi ; Suzuki, Takashi ; Kaji, Masahiro ; Horio, Hirotoshi</creatorcontrib><description>Background
To determine the usefulness of positron emission tomography (PET) with
11
C-acetate (AC) for imaging lung adenocarcinoma and evaluating its tumor aggressiveness, AC- and
18
F-fluorodeoxyglucose (FDG)-PET were compared.
Methods
One hundred and sixty-nine adenocarcinomas with clinical stage IA and 53 benign nodules were examined by both AC- and FDG-PET before surgery. The sensitivity and specificity for discriminating benign/adenocarcinoma were compared between AC- and FDG-PET. The AC and FDG uptakes were examined to determine the relationship with tumor aggressiveness, i.e., pathological tumor stage, lymphatic, vascular, or pleural involvement, and proliferative activity determined by Ki-67 staining score.
Results
While the sensitivity of AC-PET was significantly higher than FDG-PET for bronchioloalveolar carcinoma (BAC) and well-differentiated (W/D) adenocarcinoma (
p
< 0.001 and 0.006, respectively), there was no significant difference for moderately or poorly differentiated adenocarcinoma. The specificity was not different between them. While FDG uptakes were significantly higher in tumors with pathological advanced stages or those with lymphatic, vascular and/or pleural involvements than in tumors with pathological stage IA or those without these tumor involvements (
p
= 0.04 to
p
< 0.001), AC uptake did not show significant differences between the respective sub-groups except according to the tumor stage. While both AC and FDG uptakes showed a significant correlation with Ki-67 staining scores (
p
= 0.03 and
p
< 0.001, respectively), the correlation coefficient of former was lower than that of latter (
p
= 0.07).
Conclusions
While AC-PET can image BAC and W/D adenocarcinoma with a higher sensitivity than FDG-PET, it cannot evaluate tumor aggressiveness of clinical stage IA lung adenocarcinoma as well as FDG-PET.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-009-0278-9</identifier><identifier>PMID: 19562438</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Acetates - metabolism ; Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - metabolism ; Adenocarcinoma - pathology ; Carbon - metabolism ; Fluorodeoxyglucose F18 - metabolism ; Humans ; Imaging ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Medicine ; Medicine & Public Health ; Neoplasm Staging ; Nuclear Medicine ; Original Article ; Positron-Emission Tomography ; Radiology ; ROC Curve ; Tomography, X-Ray Computed ; Tumor Burden</subject><ispartof>Annals of nuclear medicine, 2009-09, Vol.23 (7), p.609-616</ispartof><rights>The Japanese Society of Nuclear Medicine 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2399-1a143f043c73bd8d4a574d1fb7df400aba5441181614b8d532fd2feed5fe11bd3</citedby><cites>FETCH-LOGICAL-c2399-1a143f043c73bd8d4a574d1fb7df400aba5441181614b8d532fd2feed5fe11bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12149-009-0278-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12149-009-0278-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19562438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shibata, Hidekatsu</creatorcontrib><creatorcontrib>Nomori, Hiroaki</creatorcontrib><creatorcontrib>Uno, Kimiichi</creatorcontrib><creatorcontrib>Iyama, Ken-ichi</creatorcontrib><creatorcontrib>Tomiyoshi, Katsumi</creatorcontrib><creatorcontrib>Nakashima, Rumi</creatorcontrib><creatorcontrib>Sakaguchi, Kazuya</creatorcontrib><creatorcontrib>Goya, Tomoyuki</creatorcontrib><creatorcontrib>Takanami, Iwao</creatorcontrib><creatorcontrib>Koizumi, Kiyoshi</creatorcontrib><creatorcontrib>Suzuki, Takashi</creatorcontrib><creatorcontrib>Kaji, Masahiro</creatorcontrib><creatorcontrib>Horio, Hirotoshi</creatorcontrib><title>11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma: comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><addtitle>Ann Nucl Med</addtitle><description>Background
To determine the usefulness of positron emission tomography (PET) with
11
C-acetate (AC) for imaging lung adenocarcinoma and evaluating its tumor aggressiveness, AC- and
18
F-fluorodeoxyglucose (FDG)-PET were compared.
Methods
One hundred and sixty-nine adenocarcinomas with clinical stage IA and 53 benign nodules were examined by both AC- and FDG-PET before surgery. The sensitivity and specificity for discriminating benign/adenocarcinoma were compared between AC- and FDG-PET. The AC and FDG uptakes were examined to determine the relationship with tumor aggressiveness, i.e., pathological tumor stage, lymphatic, vascular, or pleural involvement, and proliferative activity determined by Ki-67 staining score.
Results
While the sensitivity of AC-PET was significantly higher than FDG-PET for bronchioloalveolar carcinoma (BAC) and well-differentiated (W/D) adenocarcinoma (
p
< 0.001 and 0.006, respectively), there was no significant difference for moderately or poorly differentiated adenocarcinoma. The specificity was not different between them. While FDG uptakes were significantly higher in tumors with pathological advanced stages or those with lymphatic, vascular and/or pleural involvements than in tumors with pathological stage IA or those without these tumor involvements (
p
= 0.04 to
p
< 0.001), AC uptake did not show significant differences between the respective sub-groups except according to the tumor stage. While both AC and FDG uptakes showed a significant correlation with Ki-67 staining scores (
p
= 0.03 and
p
< 0.001, respectively), the correlation coefficient of former was lower than that of latter (
p
= 0.07).
Conclusions
While AC-PET can image BAC and W/D adenocarcinoma with a higher sensitivity than FDG-PET, it cannot evaluate tumor aggressiveness of clinical stage IA lung adenocarcinoma as well as FDG-PET.</description><subject>Acetates - metabolism</subject><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - pathology</subject><subject>Carbon - metabolism</subject><subject>Fluorodeoxyglucose F18 - metabolism</subject><subject>Humans</subject><subject>Imaging</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Lung Neoplasms - metabolism</subject><subject>Lung Neoplasms - pathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Staging</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Positron-Emission Tomography</subject><subject>Radiology</subject><subject>ROC Curve</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumor Burden</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc9u1DAQxiMEokvhAbggiwungMd2EodbtaJQqRIXOFsT_0ldJfZiJ4V9Mx4Pr7KoEhIHayzNb75v7K-qXgN9D5R2HzIwEH1NaTmsk3X_pNqBbEXdCs6fVjvag6g7kN1F9SLne0qZbCR7Xl1A37RMcLmrfgPsa9R2wcUSFxM5xOyXFAOxs8_Zl8sS5zgmPNwdiZ9x9GEk0RE9-eA1TiQvOFpyc0WmtXTQ2BA1Ju1DnPEj0XE-YPK56Pz0yx0BeV27aY0pGht_Hcdp1TFvzn_FMRhiH3BacTnZF69lnUsfxzHZstKDDaW8rJ45nLJ9da6X1ffrT9_2X-rbr59v9le3tWa872tAENxRwXXHByONwKYTBtzQGScoxQEbIQAktCAGaRrOnGHOWtM4CzAYflm923QPKf5YbV5U-RdtpwmDjWtWHRe0KVaykG__Ie_jmkJZTjFoqOh42xQINkinmHOyTh1SeXg6KqDqFKraQlUlVHUKVfVl5s1ZeB1max4nzikWgG1ALq0w2vTo_H_VPxfRsPM</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Shibata, Hidekatsu</creator><creator>Nomori, Hiroaki</creator><creator>Uno, Kimiichi</creator><creator>Iyama, Ken-ichi</creator><creator>Tomiyoshi, Katsumi</creator><creator>Nakashima, Rumi</creator><creator>Sakaguchi, Kazuya</creator><creator>Goya, Tomoyuki</creator><creator>Takanami, Iwao</creator><creator>Koizumi, Kiyoshi</creator><creator>Suzuki, Takashi</creator><creator>Kaji, Masahiro</creator><creator>Horio, Hirotoshi</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma: comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness</title><author>Shibata, Hidekatsu ; Nomori, Hiroaki ; Uno, Kimiichi ; Iyama, Ken-ichi ; Tomiyoshi, Katsumi ; Nakashima, Rumi ; Sakaguchi, Kazuya ; Goya, Tomoyuki ; Takanami, Iwao ; Koizumi, Kiyoshi ; Suzuki, Takashi ; Kaji, Masahiro ; Horio, Hirotoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2399-1a143f043c73bd8d4a574d1fb7df400aba5441181614b8d532fd2feed5fe11bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acetates - metabolism</topic><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - pathology</topic><topic>Carbon - metabolism</topic><topic>Fluorodeoxyglucose F18 - metabolism</topic><topic>Humans</topic><topic>Imaging</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Lung Neoplasms - metabolism</topic><topic>Lung Neoplasms - pathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Staging</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Positron-Emission Tomography</topic><topic>Radiology</topic><topic>ROC Curve</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumor Burden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shibata, Hidekatsu</creatorcontrib><creatorcontrib>Nomori, Hiroaki</creatorcontrib><creatorcontrib>Uno, Kimiichi</creatorcontrib><creatorcontrib>Iyama, Ken-ichi</creatorcontrib><creatorcontrib>Tomiyoshi, Katsumi</creatorcontrib><creatorcontrib>Nakashima, Rumi</creatorcontrib><creatorcontrib>Sakaguchi, Kazuya</creatorcontrib><creatorcontrib>Goya, Tomoyuki</creatorcontrib><creatorcontrib>Takanami, Iwao</creatorcontrib><creatorcontrib>Koizumi, Kiyoshi</creatorcontrib><creatorcontrib>Suzuki, Takashi</creatorcontrib><creatorcontrib>Kaji, Masahiro</creatorcontrib><creatorcontrib>Horio, Hirotoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shibata, Hidekatsu</au><au>Nomori, Hiroaki</au><au>Uno, Kimiichi</au><au>Iyama, Ken-ichi</au><au>Tomiyoshi, Katsumi</au><au>Nakashima, Rumi</au><au>Sakaguchi, Kazuya</au><au>Goya, Tomoyuki</au><au>Takanami, Iwao</au><au>Koizumi, Kiyoshi</au><au>Suzuki, Takashi</au><au>Kaji, Masahiro</au><au>Horio, Hirotoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma: comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><addtitle>Ann Nucl Med</addtitle><date>2009-09</date><risdate>2009</risdate><volume>23</volume><issue>7</issue><spage>609</spage><epage>616</epage><pages>609-616</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>Background
To determine the usefulness of positron emission tomography (PET) with
11
C-acetate (AC) for imaging lung adenocarcinoma and evaluating its tumor aggressiveness, AC- and
18
F-fluorodeoxyglucose (FDG)-PET were compared.
Methods
One hundred and sixty-nine adenocarcinomas with clinical stage IA and 53 benign nodules were examined by both AC- and FDG-PET before surgery. The sensitivity and specificity for discriminating benign/adenocarcinoma were compared between AC- and FDG-PET. The AC and FDG uptakes were examined to determine the relationship with tumor aggressiveness, i.e., pathological tumor stage, lymphatic, vascular, or pleural involvement, and proliferative activity determined by Ki-67 staining score.
Results
While the sensitivity of AC-PET was significantly higher than FDG-PET for bronchioloalveolar carcinoma (BAC) and well-differentiated (W/D) adenocarcinoma (
p
< 0.001 and 0.006, respectively), there was no significant difference for moderately or poorly differentiated adenocarcinoma. The specificity was not different between them. While FDG uptakes were significantly higher in tumors with pathological advanced stages or those with lymphatic, vascular and/or pleural involvements than in tumors with pathological stage IA or those without these tumor involvements (
p
= 0.04 to
p
< 0.001), AC uptake did not show significant differences between the respective sub-groups except according to the tumor stage. While both AC and FDG uptakes showed a significant correlation with Ki-67 staining scores (
p
= 0.03 and
p
< 0.001, respectively), the correlation coefficient of former was lower than that of latter (
p
= 0.07).
Conclusions
While AC-PET can image BAC and W/D adenocarcinoma with a higher sensitivity than FDG-PET, it cannot evaluate tumor aggressiveness of clinical stage IA lung adenocarcinoma as well as FDG-PET.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>19562438</pmid><doi>10.1007/s12149-009-0278-9</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0914-7187 |
| ispartof | Annals of nuclear medicine, 2009-09, Vol.23 (7), p.609-616 |
| issn | 0914-7187 1864-6433 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acetates - metabolism Adenocarcinoma - diagnostic imaging Adenocarcinoma - metabolism Adenocarcinoma - pathology Carbon - metabolism Fluorodeoxyglucose F18 - metabolism Humans Imaging Lung Neoplasms - diagnostic imaging Lung Neoplasms - metabolism Lung Neoplasms - pathology Medicine Medicine & Public Health Neoplasm Staging Nuclear Medicine Original Article Positron-Emission Tomography Radiology ROC Curve Tomography, X-Ray Computed Tumor Burden |
| title | 11C-acetate for positron emission tomography imaging of clinical stage IA lung adenocarcinoma: comparison with 18F-fluorodeoxyglucose for imaging and evaluation of tumor aggressiveness |
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