Mesenchymal Stem Cells Pretreated with Delivered Hph‐1‐Hsp70 Protein Are Protected from Hypoxia‐Mediated Cell Death and Rescue Heart Functions from Myocardial Injury

Mesenchymal stem cell (MSC) therapy for myocardial injury has inherent limitations due to the poor viability of MSCs after cell transplantation. In this study, we directly delivered Hsp70, a protein with protective functions against stress, into MSCs, using the Hph‐1 protein transduction domain ex v...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2009-09, Vol.27 (9), p.2283-2292
Hauptverfasser:	Chang, Woochul, Song, Byeong‐Wook, Lim, Soyeon, Song, Heesang, Shim, Chi Young, Cha, Min‐Ji, Ahn, Dong Hyuck, Jung, Young‐Gook, Lee, Dong‐Ho, Chung, Ji Hyung, Choi, Ki‐Doo, Lee, Seung‐Kyou, Chung, Namsik, Lee, Sang‐Kyou, Jang, Yangsoo, Hwang, Ki‐Chul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Carrier Proteins - genetics Caspase 3 - metabolism Cell Death - genetics Cell Death - physiology Cell Hypoxia - genetics Cell Hypoxia - physiology Cell Survival - genetics Cell Survival - physiology Cells, Cultured HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - physiology Immunohistochemistry In Situ Nick-End Labeling Male Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Myocardial infarction Myocardial Infarction - therapy Polycomb Repressive Complex 1 Protein transduction domains Rats Rats, Sprague-Dawley
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