Reproducibility of myelin water fraction analysis: a comparison of region of interest and voxel-based analysis methods
Abstract This study compared region of interest (ROI) and voxel-based analysis (VBA) methods to determine the optimal method of myelin water fraction (MWF) analysis. Twenty healthy controls were scanned twice using a multi-echo T2 relaxation sequence and ROIs were drawn in white and grey matter. MWF...
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| Veröffentlicht in: | Magnetic resonance imaging 2009-10, Vol.27 (8), p.1096-1103 |
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| creator | Meyers, Sandra M Laule, Cornelia Vavasour, Irene M Kolind, Shannon H Mädler, Burkhard Tam, Roger Traboulsee, Anthony L Lee, Jimmy Li, David K.B MacKay, Alex L |
| description | Abstract This study compared region of interest (ROI) and voxel-based analysis (VBA) methods to determine the optimal method of myelin water fraction (MWF) analysis. Twenty healthy controls were scanned twice using a multi-echo T2 relaxation sequence and ROIs were drawn in white and grey matter. MWF was defined as the fractional signal from 15 to 40 ms in the T2 distribution. For ROI analysis, the mean intensity of voxels within an ROI was fit using non-negative least squares. For VBA, MWF was obtained for each voxel and the mean and median values within an ROI were calculated. There was a slightly higher correlation between Scan 1 and 2 for the VBA method ( R2 =0.98) relative to the ROI method ( R2 =0.95), and the VBA mean square difference between scans was 300% lower, indicating VBA was the most consistent between scans. For the VBA method, mean MWF was found to be more reproducible than median MWF. As the VBA method is more reproducible and gives more options for visualization and analysis of MWF, it is recommended over the ROI method of MWF analysis. |
| doi_str_mv | 10.1016/j.mri.2009.02.001 |
| format | Article |
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Twenty healthy controls were scanned twice using a multi-echo T2 relaxation sequence and ROIs were drawn in white and grey matter. MWF was defined as the fractional signal from 15 to 40 ms in the T2 distribution. For ROI analysis, the mean intensity of voxels within an ROI was fit using non-negative least squares. For VBA, MWF was obtained for each voxel and the mean and median values within an ROI were calculated. There was a slightly higher correlation between Scan 1 and 2 for the VBA method ( R2 =0.98) relative to the ROI method ( R2 =0.95), and the VBA mean square difference between scans was 300% lower, indicating VBA was the most consistent between scans. For the VBA method, mean MWF was found to be more reproducible than median MWF. As the VBA method is more reproducible and gives more options for visualization and analysis of MWF, it is recommended over the ROI method of MWF analysis.</description><identifier>ISSN: 0730-725X</identifier><identifier>EISSN: 1873-5894</identifier><identifier>DOI: 10.1016/j.mri.2009.02.001</identifier><identifier>PMID: 19356875</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Body Water - chemistry ; Brain Chemistry ; Evoked Potentials - physiology ; Female ; Humans ; Image Interpretation, Computer-Assisted - methods ; Imaging, Three-Dimensional - methods ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Myelin water ; Nerve Fibers, Myelinated - chemistry ; Nerve Fibers, Myelinated - ultrastructure ; NNLS ; Radiology ; Reproducibility of Results ; ROC Curve ; Sensitivity and Specificity ; T2 relaxation ; Voxel-based analysis ; Water - analysis ; White matter ; Young Adult</subject><ispartof>Magnetic resonance imaging, 2009-10, Vol.27 (8), p.1096-1103</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-82b30d3cd2106e88563a1343a751a721da5f9b30bb0ed0e10f51985ffe48e2ec3</citedby><cites>FETCH-LOGICAL-c438t-82b30d3cd2106e88563a1343a751a721da5f9b30bb0ed0e10f51985ffe48e2ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0730725X0900054X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19356875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meyers, Sandra M</creatorcontrib><creatorcontrib>Laule, Cornelia</creatorcontrib><creatorcontrib>Vavasour, Irene M</creatorcontrib><creatorcontrib>Kolind, Shannon H</creatorcontrib><creatorcontrib>Mädler, Burkhard</creatorcontrib><creatorcontrib>Tam, Roger</creatorcontrib><creatorcontrib>Traboulsee, Anthony L</creatorcontrib><creatorcontrib>Lee, Jimmy</creatorcontrib><creatorcontrib>Li, David K.B</creatorcontrib><creatorcontrib>MacKay, Alex L</creatorcontrib><title>Reproducibility of myelin water fraction analysis: a comparison of region of interest and voxel-based analysis methods</title><title>Magnetic resonance imaging</title><addtitle>Magn Reson Imaging</addtitle><description>Abstract This study compared region of interest (ROI) and voxel-based analysis (VBA) methods to determine the optimal method of myelin water fraction (MWF) analysis. Twenty healthy controls were scanned twice using a multi-echo T2 relaxation sequence and ROIs were drawn in white and grey matter. MWF was defined as the fractional signal from 15 to 40 ms in the T2 distribution. For ROI analysis, the mean intensity of voxels within an ROI was fit using non-negative least squares. For VBA, MWF was obtained for each voxel and the mean and median values within an ROI were calculated. There was a slightly higher correlation between Scan 1 and 2 for the VBA method ( R2 =0.98) relative to the ROI method ( R2 =0.95), and the VBA mean square difference between scans was 300% lower, indicating VBA was the most consistent between scans. For the VBA method, mean MWF was found to be more reproducible than median MWF. As the VBA method is more reproducible and gives more options for visualization and analysis of MWF, it is recommended over the ROI method of MWF analysis.</description><subject>Adult</subject><subject>Body Water - chemistry</subject><subject>Brain Chemistry</subject><subject>Evoked Potentials - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myelin water</subject><subject>Nerve Fibers, Myelinated - chemistry</subject><subject>Nerve Fibers, Myelinated - ultrastructure</subject><subject>NNLS</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>T2 relaxation</subject><subject>Voxel-based analysis</subject><subject>Water - analysis</subject><subject>White matter</subject><subject>Young Adult</subject><issn>0730-725X</issn><issn>1873-5894</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl-L1TAQxYMo7nX1A_giedKndidNc9sqCLL4DxYWVoV9C2ky1Vzb5pq0d-23d8q9KPiwTwnhdyYz5wxjzwXkAsT2YpcP0ecFQJNDkQOIB2wj6kpmqm7Kh2wDlYSsKtTtGXuS0g4AVCHVY3YmGqm2daU27HCD-xjcbH3rez8tPHR8WLD3I78zE0beRWMnH0ZuRtMvyafX3HAbhr2JPtEz8RG_--PNjyTBNBHs-CH8xj5rTUL3V8wHnH4El56yR53pEz47nefs24f3Xy8_ZVfXHz9fvrvKbCnrKauLVoKT1hUCtljXaiuNkKU0lRKmKoQzqmsIaVtAByigU6KpVddhWWOBVp6zV8e6NOSvmTrTg08W-96MGOakK1mCIisVkS_vJamDRtLXBIojaGNIKWKn99EPJi5agF5j0TtNseg1Fg2FplhI8-JUfG4HdP8UpxwIeHMEkMw4eIw6WY-jRecj2km74O8t__Y_taUAvTX9T1ww7cIcyf-khU4k0F_WvVjXApp1Jcpb-QeC4LR1</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Meyers, Sandra M</creator><creator>Laule, Cornelia</creator><creator>Vavasour, Irene M</creator><creator>Kolind, Shannon H</creator><creator>Mädler, Burkhard</creator><creator>Tam, Roger</creator><creator>Traboulsee, Anthony L</creator><creator>Lee, Jimmy</creator><creator>Li, David K.B</creator><creator>MacKay, Alex L</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>Reproducibility of myelin water fraction analysis: a comparison of region of interest and voxel-based analysis methods</title><author>Meyers, Sandra M ; Laule, Cornelia ; Vavasour, Irene M ; Kolind, Shannon H ; Mädler, Burkhard ; Tam, Roger ; Traboulsee, Anthony L ; Lee, Jimmy ; Li, David K.B ; MacKay, Alex L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-82b30d3cd2106e88563a1343a751a721da5f9b30bb0ed0e10f51985ffe48e2ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Body Water - chemistry</topic><topic>Brain Chemistry</topic><topic>Evoked Potentials - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myelin water</topic><topic>Nerve Fibers, Myelinated - chemistry</topic><topic>Nerve Fibers, Myelinated - ultrastructure</topic><topic>NNLS</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>T2 relaxation</topic><topic>Voxel-based analysis</topic><topic>Water - analysis</topic><topic>White matter</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meyers, Sandra M</creatorcontrib><creatorcontrib>Laule, Cornelia</creatorcontrib><creatorcontrib>Vavasour, Irene M</creatorcontrib><creatorcontrib>Kolind, Shannon H</creatorcontrib><creatorcontrib>Mädler, Burkhard</creatorcontrib><creatorcontrib>Tam, Roger</creatorcontrib><creatorcontrib>Traboulsee, Anthony L</creatorcontrib><creatorcontrib>Lee, Jimmy</creatorcontrib><creatorcontrib>Li, David K.B</creatorcontrib><creatorcontrib>MacKay, Alex L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meyers, Sandra M</au><au>Laule, Cornelia</au><au>Vavasour, Irene M</au><au>Kolind, Shannon H</au><au>Mädler, Burkhard</au><au>Tam, Roger</au><au>Traboulsee, Anthony L</au><au>Lee, Jimmy</au><au>Li, David K.B</au><au>MacKay, Alex L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reproducibility of myelin water fraction analysis: a comparison of region of interest and voxel-based analysis methods</atitle><jtitle>Magnetic resonance imaging</jtitle><addtitle>Magn Reson Imaging</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>27</volume><issue>8</issue><spage>1096</spage><epage>1103</epage><pages>1096-1103</pages><issn>0730-725X</issn><eissn>1873-5894</eissn><abstract>Abstract This study compared region of interest (ROI) and voxel-based analysis (VBA) methods to determine the optimal method of myelin water fraction (MWF) analysis. Twenty healthy controls were scanned twice using a multi-echo T2 relaxation sequence and ROIs were drawn in white and grey matter. MWF was defined as the fractional signal from 15 to 40 ms in the T2 distribution. For ROI analysis, the mean intensity of voxels within an ROI was fit using non-negative least squares. For VBA, MWF was obtained for each voxel and the mean and median values within an ROI were calculated. There was a slightly higher correlation between Scan 1 and 2 for the VBA method ( R2 =0.98) relative to the ROI method ( R2 =0.95), and the VBA mean square difference between scans was 300% lower, indicating VBA was the most consistent between scans. For the VBA method, mean MWF was found to be more reproducible than median MWF. As the VBA method is more reproducible and gives more options for visualization and analysis of MWF, it is recommended over the ROI method of MWF analysis.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>19356875</pmid><doi>10.1016/j.mri.2009.02.001</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Body Water - chemistry Brain Chemistry Evoked Potentials - physiology Female Humans Image Interpretation, Computer-Assisted - methods Imaging, Three-Dimensional - methods Magnetic Resonance Imaging - methods Male Middle Aged Myelin water Nerve Fibers, Myelinated - chemistry Nerve Fibers, Myelinated - ultrastructure NNLS Radiology Reproducibility of Results ROC Curve Sensitivity and Specificity T2 relaxation Voxel-based analysis Water - analysis White matter Young Adult |
| title | Reproducibility of myelin water fraction analysis: a comparison of region of interest and voxel-based analysis methods |
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