FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus

Verruculogen is a tremorgenic mycotoxin and contains an endoperoxide bond. In this study, we describe the cloning, overexpression and purification of a non-heme Fe(ii) and alpha-ketoglutarate-dependent dioxygenase FtmOx1 from Aspergillus fumigatus, which catalyses the conversion of fumitremorgin B t...

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Veröffentlicht in:	Organic & biomolecular chemistry 2009-01, Vol.7 (19), p.4082-4087
Hauptverfasser:	Steffan, Nicola, Grundmann, Alexander, Afiyatullov, Shamil, Ruan, Hanli, Li, Shu-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus fumigatus - enzymology Biocatalysis Chromatography, High Pressure Liquid Dioxygenases - chemistry Dioxygenases - metabolism Heme Indoles - chemistry Indoles - metabolism Iron - metabolism Ketoglutaric Acids - metabolism Peroxides - chemistry Spectrometry, Mass, Electrospray Ionization
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