Novel PSEN1 and PGRN mutations in early-onset familial frontotemporal dementia

Abstract Background Frontotemporal dementia is a clinically and genetically heterogeneous syndrome. Mutations in two genes, Microtubule Associated Protein Tau (MAPT) and Progranulin (PGRN), and rarely Presenilin mutations, have been causally linked to this disorder. Objective To investigate the pres...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurobiology of aging 2009-11, Vol.30 (11), p.1825-1833
Hauptverfasser:	Bernardi, Livia, Tomaino, Carmine, Anfossi, Maria, Gallo, Maura, Geracitano, Silvana, Costanzo, Angela, Colao, Rosanna, Puccio, Gianfranco, Frangipane, Francesca, Curcio, Sabrina A.M, Mirabelli, Maria, Smirne, Nicoletta, Iapaolo, David, Maletta, Raffaele Giovanni, Bruni, Amalia C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Arginine - genetics Atypical dementia Biological and medical sciences Cysteine - genetics Development. Senescence. Regeneration. Transplantation DHPLC DNA Mutational Analysis Family Health Female Fluorodeoxyglucose F18 Frontotemporal dementia Frontotemporal Dementia - diagnostic imaging Frontotemporal Dementia - genetics Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Humans Intercellular Signaling Peptides and Proteins - genetics Internal Medicine Male Microtubule-Associated Proteins - genetics Middle Aged Mutation - genetics Neurology PGRN mutation Presenilin-1 - genetics PSEN1 mutation Radionuclide Imaging Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!