Expression and sequence of canine SIRT2 and p53 genes in canine mammary tumour cells - effects on downstream targets Wip1 and p21/Cip1

We have characterized gene dysfunction in a cellular model of spontaneous canine mammary cancer by investigating specific gene defects in SIRT2 and p53 genes for comparative studies among canine tumour-derived cell lines. These genes and their downstream targets are involved in regulating gene silen...

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Veröffentlicht in:	Veterinary & comparative oncology 2006-09, Vol.4 (3), p.161-177
Hauptverfasser:	DeInnocentes, P, Li, L.X, Sanchez, R.L, Bird, R.C
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma canine cell cycle cell lines cell proliferation dog diseases dogs gene expression gene expression regulation genes genetic disorders mammary cancer mammary neoplasms (animal) p21/Cip1 p53 reverse transcriptase polymerase chain reaction SIRT2 tumour suppressor genes Wip1
Online-Zugang:	Volltext
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