Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease
We aimed to assess whether allelic variants of dopamine receptor, glutamate receptor, and serotonin transporter genes are associated with the appearance of impulse control and related behaviors (ICRB) in Parkinson's disease (PD) with dopamine replacement therapy (DRT). We surveyed ICRB in conse...
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| Veröffentlicht in: | Movement disorders 2009-09, Vol.24 (12), p.1803-1810 |
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| creator | Lee, Jee-Young Lee, Eun Kyung Park, Sung Sup Lim, Ji-Yeon Kim, Hee Jin Kim, Ji Sun Jeon, Beom S |
| description | We aimed to assess whether allelic variants of dopamine receptor, glutamate receptor, and serotonin transporter genes are associated with the appearance of impulse control and related behaviors (ICRB) in Parkinson's disease (PD) with dopamine replacement therapy (DRT). We surveyed ICRB in consecutive Korean patients with PD who were treated with stable DRT using modified Minnesota Impulsive Disorders Interview over a period of 4 months. In the 404 patients who completed the interview and the 559 Korean healthy normal controls, genotyping was performed for variants of the DRD3 p.S9G, DRD2 Taq1A, GRIN2B c.366C>G, c.2664C>T and c.‐200T>G, and the promoter region of the serotonin transporter gene (5‐HTTLPR). Behavioral abnormalities suggestive of ICRB including compulsive buying, gambling, sexual behavior and eating, and punding, were present in 14.4% of the patients. Variants of DRD2 and 5‐HTTLPR were not associated with the risk of developing ICRB. However, the AA genotype of DRD3 p.S9G and the CC genotype of GRIN2B c.366C>G were more frequent in patients with ICRB than in nonaffected patients (odds ratio [OR] = 2.21, P = 0.0094; and 2.14, P = 0.0087, after adjusting for age and sex). After controlling for clinical variables in the multivariate analysis, carriage of either AA genotype of DRD3 or CC genotype of GRIN2B was identified as an independent risk factor for ICRB (adjusted OR: 2.57, P = 0.0087). Variants of DRD3 p.S9G and GRIN2B c.366C>G may be associated with the appearance of ICRB in PD. © 2009 Movement Disorder Society |
| doi_str_mv | 10.1002/mds.22678 |
| format | Article |
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We surveyed ICRB in consecutive Korean patients with PD who were treated with stable DRT using modified Minnesota Impulsive Disorders Interview over a period of 4 months. In the 404 patients who completed the interview and the 559 Korean healthy normal controls, genotyping was performed for variants of the DRD3 p.S9G, DRD2 Taq1A, GRIN2B c.366C>G, c.2664C>T and c.‐200T>G, and the promoter region of the serotonin transporter gene (5‐HTTLPR). Behavioral abnormalities suggestive of ICRB including compulsive buying, gambling, sexual behavior and eating, and punding, were present in 14.4% of the patients. Variants of DRD2 and 5‐HTTLPR were not associated with the risk of developing ICRB. However, the AA genotype of DRD3 p.S9G and the CC genotype of GRIN2B c.366C>G were more frequent in patients with ICRB than in nonaffected patients (odds ratio [OR] = 2.21, P = 0.0094; and 2.14, P = 0.0087, after adjusting for age and sex). After controlling for clinical variables in the multivariate analysis, carriage of either AA genotype of DRD3 or CC genotype of GRIN2B was identified as an independent risk factor for ICRB (adjusted OR: 2.57, P = 0.0087). Variants of DRD3 p.S9G and GRIN2B c.366C>G may be associated with the appearance of ICRB in PD. © 2009 Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.22678</identifier><identifier>PMID: 19562769</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Biological and medical sciences ; Brain Mapping ; Carbon Isotopes ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disruptive, Impulse Control, and Conduct Disorders - diagnostic imaging ; Disruptive, Impulse Control, and Conduct Disorders - etiology ; Disruptive, Impulse Control, and Conduct Disorders - genetics ; dopamine receptor ; Family Health ; Female ; Fluorodeoxyglucose F18 ; Gene Dosage ; Gene Frequency ; genetic association ; Genetic Predisposition to Disease ; Genotype ; glutamate NMDA receptor type 2B ; Humans ; impulse control and related behavior ; Impulsive Behavior - diagnostic imaging ; Impulsive Behavior - etiology ; Impulsive Behavior - genetics ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Middle Aged ; Neurology ; Parkinson Disease - complications ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - genetics ; Parkinson's disease ; Positron-Emission Tomography - methods ; Receptors, Dopamine D3 - genetics ; Receptors, N-Methyl-D-Aspartate - genetics ; Serotonin Plasma Membrane Transport Proteins - genetics ; serotonin transporter</subject><ispartof>Movement disorders, 2009-09, Vol.24 (12), p.1803-1810</ispartof><rights>Copyright © 2009 Movement Disorder Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4588-8634738f4ad0c51064908127a75ec4e4c915625d6c5b9f1bcc04ce70d9e5f6af3</citedby><cites>FETCH-LOGICAL-c4588-8634738f4ad0c51064908127a75ec4e4c915625d6c5b9f1bcc04ce70d9e5f6af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.22678$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.22678$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22005674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19562769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jee-Young</creatorcontrib><creatorcontrib>Lee, Eun Kyung</creatorcontrib><creatorcontrib>Park, Sung Sup</creatorcontrib><creatorcontrib>Lim, Ji-Yeon</creatorcontrib><creatorcontrib>Kim, Hee Jin</creatorcontrib><creatorcontrib>Kim, Ji Sun</creatorcontrib><creatorcontrib>Jeon, Beom S</creatorcontrib><title>Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease</title><title>Movement disorders</title><addtitle>Mov. Disord</addtitle><description>We aimed to assess whether allelic variants of dopamine receptor, glutamate receptor, and serotonin transporter genes are associated with the appearance of impulse control and related behaviors (ICRB) in Parkinson's disease (PD) with dopamine replacement therapy (DRT). We surveyed ICRB in consecutive Korean patients with PD who were treated with stable DRT using modified Minnesota Impulsive Disorders Interview over a period of 4 months. In the 404 patients who completed the interview and the 559 Korean healthy normal controls, genotyping was performed for variants of the DRD3 p.S9G, DRD2 Taq1A, GRIN2B c.366C>G, c.2664C>T and c.‐200T>G, and the promoter region of the serotonin transporter gene (5‐HTTLPR). Behavioral abnormalities suggestive of ICRB including compulsive buying, gambling, sexual behavior and eating, and punding, were present in 14.4% of the patients. Variants of DRD2 and 5‐HTTLPR were not associated with the risk of developing ICRB. However, the AA genotype of DRD3 p.S9G and the CC genotype of GRIN2B c.366C>G were more frequent in patients with ICRB than in nonaffected patients (odds ratio [OR] = 2.21, P = 0.0094; and 2.14, P = 0.0087, after adjusting for age and sex). After controlling for clinical variables in the multivariate analysis, carriage of either AA genotype of DRD3 or CC genotype of GRIN2B was identified as an independent risk factor for ICRB (adjusted OR: 2.57, P = 0.0087). Variants of DRD3 p.S9G and GRIN2B c.366C>G may be associated with the appearance of ICRB in PD. © 2009 Movement Disorder Society</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Carbon Isotopes</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disruptive, Impulse Control, and Conduct Disorders - diagnostic imaging</subject><subject>Disruptive, Impulse Control, and Conduct Disorders - etiology</subject><subject>Disruptive, Impulse Control, and Conduct Disorders - genetics</subject><subject>dopamine receptor</subject><subject>Family Health</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Gene Dosage</subject><subject>Gene Frequency</subject><subject>genetic association</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>glutamate NMDA receptor type 2B</subject><subject>Humans</subject><subject>impulse control and related behavior</subject><subject>Impulsive Behavior - diagnostic imaging</subject><subject>Impulsive Behavior - etiology</subject><subject>Impulsive Behavior - genetics</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Parkinson Disease - complications</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson's disease</subject><subject>Positron-Emission Tomography - methods</subject><subject>Receptors, Dopamine D3 - genetics</subject><subject>Receptors, N-Methyl-D-Aspartate - genetics</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>serotonin transporter</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90c1u1DAUBWALgehQWPACyBuoWKT1dfyXZenAUKkMqC3q0ngcRzUk8eCbofTtMZ2hrGDlhb9zr3VMyHNgh8AYPxpaPORcafOAzEDWUBku9UMyY8bIqgYj98gTxK-MAUhQj8keNFJxrZoZ-XKMmHx0U0wjTR2dn89r6saWLs5Pl_wNvYnTNY3DetNjoD6NU0793X0OvZtCS1fh2v2IKSONI_3k8rc4YhoPkLYRg8PwlDzqXAk_25375PO7t5cn76uzj4vTk-OzygtpTGVULXRtOuFa5iUwJRpmgGunZfAiCN9AebJslZerpoOV90z4oFnbBNkp19X75GA7d53T903AyQ4Rfeh7N4a0QatrwURTK17kq_9KDiCMACjw9Rb6nBBz6Ow6x8HlWwvM_i7eluLtXfHFvtgN3ayG0P6Vu6YLeLkDDr3ru-xGH_Hecc6YVFoUd7R1N7EPt__eaD_ML_6srraJiFP4eZ8oX2GVrrW0V8uF1cvLxdWFMKWHX-Mxp1U</recordid><startdate>20090915</startdate><enddate>20090915</enddate><creator>Lee, Jee-Young</creator><creator>Lee, Eun Kyung</creator><creator>Park, Sung Sup</creator><creator>Lim, Ji-Yeon</creator><creator>Kim, Hee Jin</creator><creator>Kim, Ji Sun</creator><creator>Jeon, Beom S</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20090915</creationdate><title>Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease</title><author>Lee, Jee-Young ; Lee, Eun Kyung ; Park, Sung Sup ; Lim, Ji-Yeon ; Kim, Hee Jin ; Kim, Ji Sun ; Jeon, Beom S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4588-8634738f4ad0c51064908127a75ec4e4c915625d6c5b9f1bcc04ce70d9e5f6af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Carbon Isotopes</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disruptive, Impulse Control, and Conduct Disorders - diagnostic imaging</topic><topic>Disruptive, Impulse Control, and Conduct Disorders - etiology</topic><topic>Disruptive, Impulse Control, and Conduct Disorders - genetics</topic><topic>dopamine receptor</topic><topic>Family Health</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Gene Dosage</topic><topic>Gene Frequency</topic><topic>genetic association</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>glutamate NMDA receptor type 2B</topic><topic>Humans</topic><topic>impulse control and related behavior</topic><topic>Impulsive Behavior - diagnostic imaging</topic><topic>Impulsive Behavior - etiology</topic><topic>Impulsive Behavior - genetics</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Parkinson Disease - complications</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson's disease</topic><topic>Positron-Emission Tomography - methods</topic><topic>Receptors, Dopamine D3 - genetics</topic><topic>Receptors, N-Methyl-D-Aspartate - genetics</topic><topic>Serotonin Plasma Membrane Transport Proteins - genetics</topic><topic>serotonin transporter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jee-Young</creatorcontrib><creatorcontrib>Lee, Eun Kyung</creatorcontrib><creatorcontrib>Park, Sung Sup</creatorcontrib><creatorcontrib>Lim, Ji-Yeon</creatorcontrib><creatorcontrib>Kim, Hee Jin</creatorcontrib><creatorcontrib>Kim, Ji Sun</creatorcontrib><creatorcontrib>Jeon, Beom S</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jee-Young</au><au>Lee, Eun Kyung</au><au>Park, Sung Sup</au><au>Lim, Ji-Yeon</au><au>Kim, Hee Jin</au><au>Kim, Ji Sun</au><au>Jeon, Beom S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov. Disord</addtitle><date>2009-09-15</date><risdate>2009</risdate><volume>24</volume><issue>12</issue><spage>1803</spage><epage>1810</epage><pages>1803-1810</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>We aimed to assess whether allelic variants of dopamine receptor, glutamate receptor, and serotonin transporter genes are associated with the appearance of impulse control and related behaviors (ICRB) in Parkinson's disease (PD) with dopamine replacement therapy (DRT). We surveyed ICRB in consecutive Korean patients with PD who were treated with stable DRT using modified Minnesota Impulsive Disorders Interview over a period of 4 months. In the 404 patients who completed the interview and the 559 Korean healthy normal controls, genotyping was performed for variants of the DRD3 p.S9G, DRD2 Taq1A, GRIN2B c.366C>G, c.2664C>T and c.‐200T>G, and the promoter region of the serotonin transporter gene (5‐HTTLPR). Behavioral abnormalities suggestive of ICRB including compulsive buying, gambling, sexual behavior and eating, and punding, were present in 14.4% of the patients. Variants of DRD2 and 5‐HTTLPR were not associated with the risk of developing ICRB. However, the AA genotype of DRD3 p.S9G and the CC genotype of GRIN2B c.366C>G were more frequent in patients with ICRB than in nonaffected patients (odds ratio [OR] = 2.21, P = 0.0094; and 2.14, P = 0.0087, after adjusting for age and sex). After controlling for clinical variables in the multivariate analysis, carriage of either AA genotype of DRD3 or CC genotype of GRIN2B was identified as an independent risk factor for ICRB (adjusted OR: 2.57, P = 0.0087). Variants of DRD3 p.S9G and GRIN2B c.366C>G may be associated with the appearance of ICRB in PD. © 2009 Movement Disorder Society</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19562769</pmid><doi>10.1002/mds.22678</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biological and medical sciences Brain Mapping Carbon Isotopes Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disruptive, Impulse Control, and Conduct Disorders - diagnostic imaging Disruptive, Impulse Control, and Conduct Disorders - etiology Disruptive, Impulse Control, and Conduct Disorders - genetics dopamine receptor Family Health Female Fluorodeoxyglucose F18 Gene Dosage Gene Frequency genetic association Genetic Predisposition to Disease Genotype glutamate NMDA receptor type 2B Humans impulse control and related behavior Impulsive Behavior - diagnostic imaging Impulsive Behavior - etiology Impulsive Behavior - genetics Magnetic Resonance Imaging - methods Male Medical sciences Middle Aged Neurology Parkinson Disease - complications Parkinson Disease - diagnostic imaging Parkinson Disease - genetics Parkinson's disease Positron-Emission Tomography - methods Receptors, Dopamine D3 - genetics Receptors, N-Methyl-D-Aspartate - genetics Serotonin Plasma Membrane Transport Proteins - genetics serotonin transporter |
| title | Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease |
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