epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma

Chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC) are associated with major changes in cell differentiation. These changes may be at the basis of the increased risk for PDAC among patients with chronic pancreatitis. Polycomb proteins are epigenetic silencers expressed in adult stem ce...

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Veröffentlicht in:	The Journal of pathology 2009-10, Vol.219 (2), p.205-213
Hauptverfasser:	Martínez-Romero, Carles, Rooman, Ilse, Skoudy, Anouchka, Guerra, Carmen, Molero, Xavier, González, Ana, Iglesias, Mar, Lobato, Tania, Bosch, Almudena, Barbacid, Mariano, Real, Francisco X, Hernández-Muñoz, Inmaculada
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar cells acinoductal metaplasia Acute Disease Animals Carcinoma, Pancreatic Ductal - metabolism Cells, Cultured Disease Models, Animal Humans immunohistochemistry Male Metaplasia - metabolism Mice Mice, Inbred C57BL Nuclear Proteins - metabolism pancreas Pancreas - metabolism Pancreas, Exocrine - metabolism Pancreas, Exocrine - pathology Pancreatic Neoplasms - metabolism pancreatitis Pancreatitis - metabolism Pancreatitis, Chronic - metabolism PDAC Polycomb Polycomb Repressive Complex 1 Precancerous Conditions - metabolism Precancerous Conditions - pathology Proto-Oncogene Proteins - metabolism Rats Rats, Wistar Repressor Proteins - metabolism Transcription Factors - metabolism
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