Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium
A liquid chromatography coupled with mass spectrometry (LC/MS) based metabonomics approach was applied to characterize the aging of rats, and the anti-aging effect of total flavones of Epimedium (TFE), a traditional Chinese medicine, has also been investigated. Serum samples collected from 4, 10, 18...
Gespeichert in:
| Veröffentlicht in: | Molecular bioSystems 2009-01, Vol.5 (10), p.1204-1213 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1213 |
|---|---|
| container_issue | 10 |
| container_start_page | 1204 |
| container_title | Molecular bioSystems |
| container_volume | 5 |
| creator | Yan, Shikai Wu, Bin Lin, Zhongying Jin, Huizi Huang, Jianhua Yang, Yun Zhang, Xinmin Shen, Ziyin Zhang, Weidong |
| description | A liquid chromatography coupled with mass spectrometry (LC/MS) based metabonomics approach was applied to characterize the aging of rats, and the anti-aging effect of total flavones of Epimedium (TFE), a traditional Chinese medicine, has also been investigated. Serum samples collected from 4, 10, 18 and 24 month-old rats and TFE-administered rats have been profiled by LC/MS. Thirty age-related endogenous metabolites were discovered by partial least squares (PLS) and Hotelling's T(2) control chart, among which 25 metabolites were structurally identified by MS(n) analysis and ten of them were further confirmed via authentic chemicals. All important age-related metabolites, such as unsaturated fatty acids, saturated fatty acids, nucleotides, carnosine, ergothioneine and amino acids, displayed age-related changes, and most of them were reset to a younger level after TFE administration. This study indicated that aging could be characterized by changes of lipid metabolisms and accumulation of free radicals. The anti-aging effects of TFE might due to the intervention on lipid metabolism and its property of anti-oxidation. |
| doi_str_mv | 10.1039/b816407j |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734048624</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734048624</sourcerecordid><originalsourceid>FETCH-LOGICAL-c282t-40acfb4905df9fb15eb86b53a1fccb5a28e99291ef2ca49ea6d9d7db5a02ead13</originalsourceid><addsrcrecordid>eNpFkMtOwzAQRS0EoqUg8QUoO9gEbMd5eIlQeUhFbEBiF02ccesqsUPsVoKvJ6UBVjOae-Zq5hJyzug1o4m8qQqWCZqvD8iU5YLHnKbs8K_P3ifkxPs1pUkhGD0mEybzNEsYnZLuGQNUzrrWqEitoAcVsDdfEIyzkdMRLI1dRmDryNgt-mCWo2SjsMJBCCbeM6g1quB3S8EFaCLdwNZZ_JnMO9NibTbtKTnS0Hg8G-uMvN3PX-8e48XLw9Pd7SJWvOAhFhSUroSkaa2lrliKVZFVaQJMK1WlwAuUkkuGmisQEiGrZZ3Xg0I5Qs2SGbnc-3a9-9gMh5et8QqbBiy6jS_zRFBRZFwM5NWeVL3zvkdddr1pof8sGS138Za_8Q7oxWi6qYZ3_sExz-QbbpN4AQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734048624</pqid></control><display><type>article</type><title>Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals</source><source>Alma/SFX Local Collection</source><creator>Yan, Shikai ; Wu, Bin ; Lin, Zhongying ; Jin, Huizi ; Huang, Jianhua ; Yang, Yun ; Zhang, Xinmin ; Shen, Ziyin ; Zhang, Weidong</creator><creatorcontrib>Yan, Shikai ; Wu, Bin ; Lin, Zhongying ; Jin, Huizi ; Huang, Jianhua ; Yang, Yun ; Zhang, Xinmin ; Shen, Ziyin ; Zhang, Weidong</creatorcontrib><description>A liquid chromatography coupled with mass spectrometry (LC/MS) based metabonomics approach was applied to characterize the aging of rats, and the anti-aging effect of total flavones of Epimedium (TFE), a traditional Chinese medicine, has also been investigated. Serum samples collected from 4, 10, 18 and 24 month-old rats and TFE-administered rats have been profiled by LC/MS. Thirty age-related endogenous metabolites were discovered by partial least squares (PLS) and Hotelling's T(2) control chart, among which 25 metabolites were structurally identified by MS(n) analysis and ten of them were further confirmed via authentic chemicals. All important age-related metabolites, such as unsaturated fatty acids, saturated fatty acids, nucleotides, carnosine, ergothioneine and amino acids, displayed age-related changes, and most of them were reset to a younger level after TFE administration. This study indicated that aging could be characterized by changes of lipid metabolisms and accumulation of free radicals. The anti-aging effects of TFE might due to the intervention on lipid metabolism and its property of anti-oxidation.</description><identifier>ISSN: 1742-206X</identifier><identifier>EISSN: 1742-2051</identifier><identifier>DOI: 10.1039/b816407j</identifier><identifier>PMID: 19756310</identifier><language>eng</language><publisher>England</publisher><subject>Aging - blood ; Aging - drug effects ; Aging - metabolism ; Animals ; Body Weight - drug effects ; Chromatography, High Pressure Liquid ; Epimedium - chemistry ; Flavones - administration & dosage ; Flavones - analysis ; Flavones - chemistry ; Flavones - pharmacology ; Free Radical Scavengers - metabolism ; Least-Squares Analysis ; Male ; Malondialdehyde - metabolism ; Mass Spectrometry ; Metabolomics ; Multivariate Analysis ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - analysis ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Principal Component Analysis ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase - metabolism ; Ultraviolet Rays</subject><ispartof>Molecular bioSystems, 2009-01, Vol.5 (10), p.1204-1213</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-40acfb4905df9fb15eb86b53a1fccb5a28e99291ef2ca49ea6d9d7db5a02ead13</citedby><cites>FETCH-LOGICAL-c282t-40acfb4905df9fb15eb86b53a1fccb5a28e99291ef2ca49ea6d9d7db5a02ead13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19756310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Shikai</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><creatorcontrib>Lin, Zhongying</creatorcontrib><creatorcontrib>Jin, Huizi</creatorcontrib><creatorcontrib>Huang, Jianhua</creatorcontrib><creatorcontrib>Yang, Yun</creatorcontrib><creatorcontrib>Zhang, Xinmin</creatorcontrib><creatorcontrib>Shen, Ziyin</creatorcontrib><creatorcontrib>Zhang, Weidong</creatorcontrib><title>Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium</title><title>Molecular bioSystems</title><addtitle>Mol Biosyst</addtitle><description>A liquid chromatography coupled with mass spectrometry (LC/MS) based metabonomics approach was applied to characterize the aging of rats, and the anti-aging effect of total flavones of Epimedium (TFE), a traditional Chinese medicine, has also been investigated. Serum samples collected from 4, 10, 18 and 24 month-old rats and TFE-administered rats have been profiled by LC/MS. Thirty age-related endogenous metabolites were discovered by partial least squares (PLS) and Hotelling's T(2) control chart, among which 25 metabolites were structurally identified by MS(n) analysis and ten of them were further confirmed via authentic chemicals. All important age-related metabolites, such as unsaturated fatty acids, saturated fatty acids, nucleotides, carnosine, ergothioneine and amino acids, displayed age-related changes, and most of them were reset to a younger level after TFE administration. This study indicated that aging could be characterized by changes of lipid metabolisms and accumulation of free radicals. The anti-aging effects of TFE might due to the intervention on lipid metabolism and its property of anti-oxidation.</description><subject>Aging - blood</subject><subject>Aging - drug effects</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Epimedium - chemistry</subject><subject>Flavones - administration & dosage</subject><subject>Flavones - analysis</subject><subject>Flavones - chemistry</subject><subject>Flavones - pharmacology</subject><subject>Free Radical Scavengers - metabolism</subject><subject>Least-Squares Analysis</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Mass Spectrometry</subject><subject>Metabolomics</subject><subject>Multivariate Analysis</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - analysis</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Principal Component Analysis</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Ultraviolet Rays</subject><issn>1742-206X</issn><issn>1742-2051</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0EoqUg8QUoO9gEbMd5eIlQeUhFbEBiF02ccesqsUPsVoKvJ6UBVjOae-Zq5hJyzug1o4m8qQqWCZqvD8iU5YLHnKbs8K_P3ifkxPs1pUkhGD0mEybzNEsYnZLuGQNUzrrWqEitoAcVsDdfEIyzkdMRLI1dRmDryNgt-mCWo2SjsMJBCCbeM6g1quB3S8EFaCLdwNZZ_JnMO9NibTbtKTnS0Hg8G-uMvN3PX-8e48XLw9Pd7SJWvOAhFhSUroSkaa2lrliKVZFVaQJMK1WlwAuUkkuGmisQEiGrZZ3Xg0I5Qs2SGbnc-3a9-9gMh5et8QqbBiy6jS_zRFBRZFwM5NWeVL3zvkdddr1pof8sGS138Za_8Q7oxWi6qYZ3_sExz-QbbpN4AQ</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Yan, Shikai</creator><creator>Wu, Bin</creator><creator>Lin, Zhongying</creator><creator>Jin, Huizi</creator><creator>Huang, Jianhua</creator><creator>Yang, Yun</creator><creator>Zhang, Xinmin</creator><creator>Shen, Ziyin</creator><creator>Zhang, Weidong</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090101</creationdate><title>Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium</title><author>Yan, Shikai ; Wu, Bin ; Lin, Zhongying ; Jin, Huizi ; Huang, Jianhua ; Yang, Yun ; Zhang, Xinmin ; Shen, Ziyin ; Zhang, Weidong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-40acfb4905df9fb15eb86b53a1fccb5a28e99291ef2ca49ea6d9d7db5a02ead13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aging - blood</topic><topic>Aging - drug effects</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Epimedium - chemistry</topic><topic>Flavones - administration & dosage</topic><topic>Flavones - analysis</topic><topic>Flavones - chemistry</topic><topic>Flavones - pharmacology</topic><topic>Free Radical Scavengers - metabolism</topic><topic>Least-Squares Analysis</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Mass Spectrometry</topic><topic>Metabolomics</topic><topic>Multivariate Analysis</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - analysis</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Principal Component Analysis</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Ultraviolet Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Shikai</creatorcontrib><creatorcontrib>Wu, Bin</creatorcontrib><creatorcontrib>Lin, Zhongying</creatorcontrib><creatorcontrib>Jin, Huizi</creatorcontrib><creatorcontrib>Huang, Jianhua</creatorcontrib><creatorcontrib>Yang, Yun</creatorcontrib><creatorcontrib>Zhang, Xinmin</creatorcontrib><creatorcontrib>Shen, Ziyin</creatorcontrib><creatorcontrib>Zhang, Weidong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular bioSystems</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Shikai</au><au>Wu, Bin</au><au>Lin, Zhongying</au><au>Jin, Huizi</au><au>Huang, Jianhua</au><au>Yang, Yun</au><au>Zhang, Xinmin</au><au>Shen, Ziyin</au><au>Zhang, Weidong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium</atitle><jtitle>Molecular bioSystems</jtitle><addtitle>Mol Biosyst</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>5</volume><issue>10</issue><spage>1204</spage><epage>1213</epage><pages>1204-1213</pages><issn>1742-206X</issn><eissn>1742-2051</eissn><abstract>A liquid chromatography coupled with mass spectrometry (LC/MS) based metabonomics approach was applied to characterize the aging of rats, and the anti-aging effect of total flavones of Epimedium (TFE), a traditional Chinese medicine, has also been investigated. Serum samples collected from 4, 10, 18 and 24 month-old rats and TFE-administered rats have been profiled by LC/MS. Thirty age-related endogenous metabolites were discovered by partial least squares (PLS) and Hotelling's T(2) control chart, among which 25 metabolites were structurally identified by MS(n) analysis and ten of them were further confirmed via authentic chemicals. All important age-related metabolites, such as unsaturated fatty acids, saturated fatty acids, nucleotides, carnosine, ergothioneine and amino acids, displayed age-related changes, and most of them were reset to a younger level after TFE administration. This study indicated that aging could be characterized by changes of lipid metabolisms and accumulation of free radicals. The anti-aging effects of TFE might due to the intervention on lipid metabolism and its property of anti-oxidation.</abstract><cop>England</cop><pmid>19756310</pmid><doi>10.1039/b816407j</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1742-206X |
| ispartof | Molecular bioSystems, 2009-01, Vol.5 (10), p.1204-1213 |
| issn | 1742-206X 1742-2051 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734048624 |
| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Aging - blood Aging - drug effects Aging - metabolism Animals Body Weight - drug effects Chromatography, High Pressure Liquid Epimedium - chemistry Flavones - administration & dosage Flavones - analysis Flavones - chemistry Flavones - pharmacology Free Radical Scavengers - metabolism Least-Squares Analysis Male Malondialdehyde - metabolism Mass Spectrometry Metabolomics Multivariate Analysis Phytotherapy Plant Extracts - administration & dosage Plant Extracts - analysis Plant Extracts - chemistry Plant Extracts - pharmacology Principal Component Analysis Rats Rats, Sprague-Dawley Superoxide Dismutase - metabolism Ultraviolet Rays |
| title | Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T23%3A55%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabonomic%20characterization%20of%20aging%20and%20investigation%20on%20the%20anti-aging%20effects%20of%20total%20flavones%20of%20Epimedium&rft.jtitle=Molecular%20bioSystems&rft.au=Yan,%20Shikai&rft.date=2009-01-01&rft.volume=5&rft.issue=10&rft.spage=1204&rft.epage=1213&rft.pages=1204-1213&rft.issn=1742-206X&rft.eissn=1742-2051&rft_id=info:doi/10.1039/b816407j&rft_dat=%3Cproquest_cross%3E734048624%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=734048624&rft_id=info:pmid/19756310&rfr_iscdi=true |