Effects of Antiatherosclerosis in Carotid Artery by RNAi-Mediated Silencing of MCP-1 Expression

Background Our objective was to identify the effects of MCP-1 siRNA in vivo transfection in an atherosclerosis model on local expression of MCP-1 and pathogenesis of atherosclerosis. Methods Carotid atherosclerosis was induced in 28 New Zealand white rabbits. Rabbits were divided into three groups r...

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Veröffentlicht in:	Annals of vascular surgery 2009-09, Vol.23 (5), p.652-662
Hauptverfasser:	Hu, Zuo-jun, Liao, Yi, Hu, Ling-yu, Wang, Jia-li, Li, Jie, Lu, Wei-ming, Wang, Shen-ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Blotting, Western Carotid Arteries - metabolism Carotid Arteries - pathology Carotid Artery Diseases - genetics Carotid Artery Diseases - metabolism Carotid Artery Diseases - pathology Carotid Artery Diseases - therapy Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Disease Models, Animal Disease Progression Down-Regulation Genetic Therapy - methods Genetic Vectors Immunohistochemistry Male Molecular Sequence Data Rabbits Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNA, Small Interfering - metabolism Surgery Transfection
Online-Zugang:	Volltext
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