Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry

Perhexiline is a drug that is used for treatment of moderate to severe angina pectoris that has not responded to other treatment. It has a low therapeutic index, and saturable metabolism that is also subject to genetic polymorphism (CYP2D6). Concentration monitoring of the parent drug and its major...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2009-10, Vol.877 (27), p.3025-3030
Hauptverfasser:	Zhang, Mei, Moore, Grant A., Barclay, Murray L., Begg, Evan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, Liquid - methods Doxepin - analogs & derivatives Doxepin - chemistry Fundamental and applied biological sciences. Psychology General pharmacology Humans Hydroxyperhexiline LC–MS/MS Linear Models Medical sciences Perhexiline Perhexiline - analogs & derivatives Perhexiline - blood Pharmacology. Drug treatments Plasma Reproducibility of Results Sensitivity and Specificity Tandem Mass Spectrometry - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!