Synthesis and antiviral activity of HCV NS3/4A peptidomimetic boronic acid inhibitors

The synthesis and evaluation of a series of peptidomimetic boronic acid inhibitors of the HCV NS3/4A protease is described. Data on their biochemical and cellular activities, mutant protease activity, and genotype coverage is reported. A new series of NS3/4A protease boronic acid inhibitors is descr...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-10, Vol.19 (19), p.5708-5711
Hauptverfasser:	Boloor, Amogh, Hanway, Denise, Joshi, Maria, Winn, David T., Mendez, Gabriel, Walls, Marlena, Wei, Ping, Qian, Fuxin, Zhang, Xiaoli, Zhang, Yuliang, Hepperle, Michael E., Li, Xinqiang, Campbell, David A., Betancort, Juan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Boronic acids Boronic Acids - chemical synthesis Boronic Acids - chemistry Boronic Acids - pharmacology Carrier Proteins - antagonists & inhibitors Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor Genotype HCV Hepacivirus - drug effects Hepacivirus - genetics Hepatitis C Hepatitis C - drug therapy Hepatitis C virus Humans Medical sciences Mutant Proteins - antagonists & inhibitors Mutant Proteins - metabolism NS3/4A Pharmacology. Drug treatments Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Viral Proteins - antagonists & inhibitors Viral Proteins - genetics Viral Proteins - metabolism
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