Influence of melatonin therapy and orchiectomy on T cell subsets in male Wistar rats infected with Trypanosoma cruzi
: Gonadal steroids exert an important influence on the host immune response during infection. Changes resulting from the absence or replacement of gonadal hormones may represent a distinct evolution of a particular parasite. Taking into account the greater susceptibility of males to parasites, the...
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| Veröffentlicht in: | Journal of pineal research 2009-10, Vol.47 (3), p.271-276 |
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| creator | Santello, Fabricia H. Del Vecchio Filipin, Marina Caetano, Leony C. Brazão, Vânia Caetano, Luana N. Dos Santos, Carla D. Alonso Toldo, Míriam P. Do Prado Jr, José C. |
| description | : Gonadal steroids exert an important influence on the host immune response during infection. Changes resulting from the absence or replacement of gonadal hormones may represent a distinct evolution of a particular parasite. Taking into account the greater susceptibility of males to parasites, the magnitude of the immune response seems to depend on the interaction of many hormones that will act synergistically with other immune cells. The aims of this research were to evaluate the effects of the luck of male sex hormones due to orchiectomy, and the influence of oral administration of melatonin on the immune response of male Wistar rats infected with the Y strain of Trypanosoma cruzi. The percentage of CD3+ CD4+ and CD3+ CD8+ lymphocyte T cell subsets were evaluated using flow cytometry and the measurement of IL‐2 and IL‐12. For all parameters examined, a synergistic action of melatonin and orchiectomy on the host’s immune response was observed, promoting an effective response against the parasite during the acute phase of infection. These results offer insight into other possibilities for possibly controlling T. cruzi proliferation through melatonin therapy and also the stimulatory effects on host’s immune response triggered by the absence of male gonadal steroids during the acute phase of infection. |
| doi_str_mv | 10.1111/j.1600-079X.2009.00710.x |
| format | Article |
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Changes resulting from the absence or replacement of gonadal hormones may represent a distinct evolution of a particular parasite. Taking into account the greater susceptibility of males to parasites, the magnitude of the immune response seems to depend on the interaction of many hormones that will act synergistically with other immune cells. The aims of this research were to evaluate the effects of the luck of male sex hormones due to orchiectomy, and the influence of oral administration of melatonin on the immune response of male Wistar rats infected with the Y strain of Trypanosoma cruzi. The percentage of CD3+ CD4+ and CD3+ CD8+ lymphocyte T cell subsets were evaluated using flow cytometry and the measurement of IL‐2 and IL‐12. For all parameters examined, a synergistic action of melatonin and orchiectomy on the host’s immune response was observed, promoting an effective response against the parasite during the acute phase of infection. These results offer insight into other possibilities for possibly controlling T. cruzi proliferation through melatonin therapy and also the stimulatory effects on host’s immune response triggered by the absence of male gonadal steroids during the acute phase of infection.</description><identifier>ISSN: 0742-3098</identifier><identifier>EISSN: 1600-079X</identifier><identifier>DOI: 10.1111/j.1600-079X.2009.00710.x</identifier><identifier>PMID: 19709396</identifier><identifier>CODEN: JPRSE9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Biological and medical sciences ; CD3 Complex - metabolism ; CD4-Positive T-Lymphocytes - drug effects ; CD4-Positive T-Lymphocytes - immunology ; Central Nervous System Depressants - pharmacology ; Central Nervous System Depressants - therapeutic use ; Chagas Disease - drug therapy ; Chagas Disease - immunology ; flow citometry ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; IL-2 ; Interleukin-12 - metabolism ; Interleukin-2 - metabolism ; Male ; melatonin ; Melatonin - pharmacology ; Melatonin - therapeutic use ; Orchiectomy ; Rats ; Rats, Wistar ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology ; Trypanosoma cruzi ; Vertebrates: endocrinology</subject><ispartof>Journal of pineal research, 2009-10, Vol.47 (3), p.271-276</ispartof><rights>2009 The Authors. 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Changes resulting from the absence or replacement of gonadal hormones may represent a distinct evolution of a particular parasite. Taking into account the greater susceptibility of males to parasites, the magnitude of the immune response seems to depend on the interaction of many hormones that will act synergistically with other immune cells. The aims of this research were to evaluate the effects of the luck of male sex hormones due to orchiectomy, and the influence of oral administration of melatonin on the immune response of male Wistar rats infected with the Y strain of Trypanosoma cruzi. The percentage of CD3+ CD4+ and CD3+ CD8+ lymphocyte T cell subsets were evaluated using flow cytometry and the measurement of IL‐2 and IL‐12. For all parameters examined, a synergistic action of melatonin and orchiectomy on the host’s immune response was observed, promoting an effective response against the parasite during the acute phase of infection. These results offer insight into other possibilities for possibly controlling T. cruzi proliferation through melatonin therapy and also the stimulatory effects on host’s immune response triggered by the absence of male gonadal steroids during the acute phase of infection.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>CD3 Complex - metabolism</subject><subject>CD4-Positive T-Lymphocytes - drug effects</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Central Nervous System Depressants - therapeutic use</subject><subject>Chagas Disease - drug therapy</subject><subject>Chagas Disease - immunology</subject><subject>flow citometry</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>IL-2</subject><subject>Interleukin-12 - metabolism</subject><subject>Interleukin-2 - metabolism</subject><subject>Male</subject><subject>melatonin</subject><subject>Melatonin - pharmacology</subject><subject>Melatonin - therapeutic use</subject><subject>Orchiectomy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><subject>Trypanosoma cruzi</subject><subject>Vertebrates: endocrinology</subject><issn>0742-3098</issn><issn>1600-079X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtvEzEURi0EoqHwF5A3wGrS6_GMHxIbVPWRqiosgtKd5fHcUSbMI9gzaoZfj9NE6Q7hjS3f89lX9xBCGcxZXBebORMACUj9OE8B9BxAxtruFZmdCq_JDGSWJhy0OiPvQtgAgFJKvCVnTEvQXIsZGRZd1YzYOaR9RVts7NB3dUeHNXq7najtStp7t67RDX070b6jS-qwaWgYi4BDoBFubYN0VYfBeurt810VeSzpUz2s6dJPW9v1oW8tdX78U78nbyrbBPxw3M_Jz-ur5eVtcv_9ZnH57T5xmRCQsLxA1BpKBOV4USoN4KwoLUipOEuFK7XCXKZKFxnPcy1tbrXKhdSFLVLk5-TL4d2t73-PGAbT1mHfvO2wH4ORPIOMg2CR_PxPMgWVpXGSEVQH0Pk-BI-V2fq6tX4yDMzejdmYvQKzV2D2bsyzG7OL0Y_HP8aixfIleJQRgU9HwAZnm8rbztXhxKVMszgXFbmvB-6pbnD67wbM3Y9FPMR4cohHYbg7xa3_ZYTkMjerhxtzrZf56vH2wdzxv-EiulY</recordid><startdate>200910</startdate><enddate>200910</enddate><creator>Santello, Fabricia H.</creator><creator>Del Vecchio Filipin, Marina</creator><creator>Caetano, Leony C.</creator><creator>Brazão, Vânia</creator><creator>Caetano, Luana N.</creator><creator>Dos Santos, Carla D.</creator><creator>Alonso Toldo, Míriam P.</creator><creator>Do Prado Jr, José C.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200910</creationdate><title>Influence of melatonin therapy and orchiectomy on T cell subsets in male Wistar rats infected with Trypanosoma cruzi</title><author>Santello, Fabricia H. ; Del Vecchio Filipin, Marina ; Caetano, Leony C. ; Brazão, Vânia ; Caetano, Luana N. ; Dos Santos, Carla D. ; Alonso Toldo, Míriam P. ; Do Prado Jr, José C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4660-15bee990de08c3bd8900ca6da07783126cd98e57289b435597a5a985679bab2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>CD3 Complex - metabolism</topic><topic>CD4-Positive T-Lymphocytes - drug effects</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Central Nervous System Depressants - therapeutic use</topic><topic>Chagas Disease - drug therapy</topic><topic>Chagas Disease - immunology</topic><topic>flow citometry</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>IL-2</topic><topic>Interleukin-12 - metabolism</topic><topic>Interleukin-2 - metabolism</topic><topic>Male</topic><topic>melatonin</topic><topic>Melatonin - pharmacology</topic><topic>Melatonin - therapeutic use</topic><topic>Orchiectomy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - immunology</topic><topic>Trypanosoma cruzi</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santello, Fabricia H.</creatorcontrib><creatorcontrib>Del Vecchio Filipin, Marina</creatorcontrib><creatorcontrib>Caetano, Leony C.</creatorcontrib><creatorcontrib>Brazão, Vânia</creatorcontrib><creatorcontrib>Caetano, Luana N.</creatorcontrib><creatorcontrib>Dos Santos, Carla D.</creatorcontrib><creatorcontrib>Alonso Toldo, Míriam P.</creatorcontrib><creatorcontrib>Do Prado Jr, José C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pineal research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santello, Fabricia H.</au><au>Del Vecchio Filipin, Marina</au><au>Caetano, Leony C.</au><au>Brazão, Vânia</au><au>Caetano, Luana N.</au><au>Dos Santos, Carla D.</au><au>Alonso Toldo, Míriam P.</au><au>Do Prado Jr, José C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of melatonin therapy and orchiectomy on T cell subsets in male Wistar rats infected with Trypanosoma cruzi</atitle><jtitle>Journal of pineal research</jtitle><addtitle>J Pineal Res</addtitle><date>2009-10</date><risdate>2009</risdate><volume>47</volume><issue>3</issue><spage>271</spage><epage>276</epage><pages>271-276</pages><issn>0742-3098</issn><eissn>1600-079X</eissn><coden>JPRSE9</coden><abstract>: Gonadal steroids exert an important influence on the host immune response during infection. Changes resulting from the absence or replacement of gonadal hormones may represent a distinct evolution of a particular parasite. Taking into account the greater susceptibility of males to parasites, the magnitude of the immune response seems to depend on the interaction of many hormones that will act synergistically with other immune cells. The aims of this research were to evaluate the effects of the luck of male sex hormones due to orchiectomy, and the influence of oral administration of melatonin on the immune response of male Wistar rats infected with the Y strain of Trypanosoma cruzi. The percentage of CD3+ CD4+ and CD3+ CD8+ lymphocyte T cell subsets were evaluated using flow cytometry and the measurement of IL‐2 and IL‐12. For all parameters examined, a synergistic action of melatonin and orchiectomy on the host’s immune response was observed, promoting an effective response against the parasite during the acute phase of infection. These results offer insight into other possibilities for possibly controlling T. cruzi proliferation through melatonin therapy and also the stimulatory effects on host’s immune response triggered by the absence of male gonadal steroids during the acute phase of infection.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19709396</pmid><doi>10.1111/j.1600-079X.2009.00710.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences CD3 Complex - metabolism CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Central Nervous System Depressants - pharmacology Central Nervous System Depressants - therapeutic use Chagas Disease - drug therapy Chagas Disease - immunology flow citometry Flow Cytometry Fundamental and applied biological sciences. Psychology IL-2 Interleukin-12 - metabolism Interleukin-2 - metabolism Male melatonin Melatonin - pharmacology Melatonin - therapeutic use Orchiectomy Rats Rats, Wistar T-Lymphocytes - drug effects T-Lymphocytes - immunology Trypanosoma cruzi Vertebrates: endocrinology |
| title | Influence of melatonin therapy and orchiectomy on T cell subsets in male Wistar rats infected with Trypanosoma cruzi |
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