Small changes in six-minute walk distance are important in diffuse parenchymal lung disease
Summary The aim of this study was to determine the minimal important difference for the six-minute walk distance in people with diffuse parenchymal lung disease. Methods Forty-eight subjects (24 idiopathic pulmonary fibrosis) undertook the six-minute walk test before and after an 8-week exercise pro...
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| Veröffentlicht in: | Respiratory medicine 2009-10, Vol.103 (10), p.1430-1435 |
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| creator | Holland, Anne E Hill, Catherine J Conron, Matthew Munro, Prue McDonald, Christine F |
| description | Summary The aim of this study was to determine the minimal important difference for the six-minute walk distance in people with diffuse parenchymal lung disease. Methods Forty-eight subjects (24 idiopathic pulmonary fibrosis) undertook the six-minute walk test before and after an 8-week exercise program. The minimal important difference was calculated using a distribution-based and an anchor-based method. A global rating of change scale was used as the external criterion to judge patients as clinically unchanged or changed. Results The mean change in six-minute walk distance in improved subjects was 50.0 m, compared to 4.0 m in unchanged subjects and a reduction of 64.3 m in those classified as worse ( p < 0.001). The receiver operating characteristic curve indicated a cut-off value for meaningful change of 30.5 m (area under the curve 0.89, 95% confidence interval 0.81–0.98) whilst the standard error of the mean method indicated a value of 33 m. Similar values were obtained when only subjects with idiopathic pulmonary fibrosis were included (29 and 34 m, respectively). Conclusions Small differences in six-minute walk distance, in the range 29–34 m, may be clinically significant for people with diffuse parenchymal lung disease. |
| doi_str_mv | 10.1016/j.rmed.2009.04.024 |
| format | Article |
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Methods Forty-eight subjects (24 idiopathic pulmonary fibrosis) undertook the six-minute walk test before and after an 8-week exercise program. The minimal important difference was calculated using a distribution-based and an anchor-based method. A global rating of change scale was used as the external criterion to judge patients as clinically unchanged or changed. Results The mean change in six-minute walk distance in improved subjects was 50.0 m, compared to 4.0 m in unchanged subjects and a reduction of 64.3 m in those classified as worse ( p < 0.001). The receiver operating characteristic curve indicated a cut-off value for meaningful change of 30.5 m (area under the curve 0.89, 95% confidence interval 0.81–0.98) whilst the standard error of the mean method indicated a value of 33 m. Similar values were obtained when only subjects with idiopathic pulmonary fibrosis were included (29 and 34 m, respectively). Conclusions Small differences in six-minute walk distance, in the range 29–34 m, may be clinically significant for people with diffuse parenchymal lung disease.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2009.04.024</identifier><identifier>PMID: 19477109</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Analysis of Variance ; Area Under Curve ; Biological and medical sciences ; Confidence intervals ; Disease ; Exercise test ; Exercise Test - methods ; Exercise Therapy ; Female ; Forced Expiratory Volume - physiology ; Humans ; Idiopathic Pulmonary Fibrosis - physiopathology ; Male ; Medical sciences ; Methods ; Middle Aged ; Outcome assessment ; Pneumology ; Practice Guidelines as Topic ; Pulmonary fibrosis ; Pulmonary/Respiratory ; Respiratory system : syndromes and miscellaneous diseases ; Studies ; Time Factors ; Walking ; Walking - physiology</subject><ispartof>Respiratory medicine, 2009-10, Vol.103 (10), p.1430-1435</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-d65a401f6cdd0e29cddbc5bb8415d34c57d4df41de678f5f3bf634016c0df54c3</citedby><cites>FETCH-LOGICAL-c578t-d65a401f6cdd0e29cddbc5bb8415d34c57d4df41de678f5f3bf634016c0df54c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rmed.2009.04.024$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22355768$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19477109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holland, Anne E</creatorcontrib><creatorcontrib>Hill, Catherine J</creatorcontrib><creatorcontrib>Conron, Matthew</creatorcontrib><creatorcontrib>Munro, Prue</creatorcontrib><creatorcontrib>McDonald, Christine F</creatorcontrib><title>Small changes in six-minute walk distance are important in diffuse parenchymal lung disease</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Summary The aim of this study was to determine the minimal important difference for the six-minute walk distance in people with diffuse parenchymal lung disease. Methods Forty-eight subjects (24 idiopathic pulmonary fibrosis) undertook the six-minute walk test before and after an 8-week exercise program. The minimal important difference was calculated using a distribution-based and an anchor-based method. A global rating of change scale was used as the external criterion to judge patients as clinically unchanged or changed. Results The mean change in six-minute walk distance in improved subjects was 50.0 m, compared to 4.0 m in unchanged subjects and a reduction of 64.3 m in those classified as worse ( p < 0.001). The receiver operating characteristic curve indicated a cut-off value for meaningful change of 30.5 m (area under the curve 0.89, 95% confidence interval 0.81–0.98) whilst the standard error of the mean method indicated a value of 33 m. Similar values were obtained when only subjects with idiopathic pulmonary fibrosis were included (29 and 34 m, respectively). Conclusions Small differences in six-minute walk distance, in the range 29–34 m, may be clinically significant for people with diffuse parenchymal lung disease.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Confidence intervals</subject><subject>Disease</subject><subject>Exercise test</subject><subject>Exercise Test - methods</subject><subject>Exercise Therapy</subject><subject>Female</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Humans</subject><subject>Idiopathic Pulmonary Fibrosis - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Outcome assessment</subject><subject>Pneumology</subject><subject>Practice Guidelines as Topic</subject><subject>Pulmonary fibrosis</subject><subject>Pulmonary/Respiratory</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Studies</subject><subject>Time Factors</subject><subject>Walking</subject><subject>Walking - physiology</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk1r3DAQhkVpaTbb_oEeiqGUnOyOZMleQymU0I9AIIe0px6ELI0Sbfyxley2--87ZpcEcshJiHne0ehhGHvDoeDAqw_bIvboCgHQFCALEPIZW3FViryESj5nK2iUzCvO-Qk7TWkLBEoJL9kJb2Rdc2hW7Nd1b7ous7dmuMGUhSFL4V_eh2GeMPtrurvMhTSZwWJmImah342RrtNCuuD9nDDbUWWwt3vqlHXzcLNE0CR8xV540yV8fTzX7OfXLz_Ov-eXV98uzj9f5lbVmyl3lTISuK-sc4CioaO1qm03kitXSoKcdF5yh1W98cqXra9KClQWnFfSlmt2dui7i-PvGdOk-5Asdp0ZcJyTromWIMjMmr17RG7HOQ40nOZQKi6k4DVR4kDZOKYU0etdDL2Je4L0Yl5v9WJeL-Y1SE3mKfT22Hpul9p95KiagPdHwCRrOh9Jakj3nBClUnW1Ie7jgUNS9idg1MkG8osuRLSTdmN4eo5Pj-K2C0OgF-9wj-nhvzoJDfp62ZFlRaAB4LKW5X8ru7ae</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Holland, Anne E</creator><creator>Hill, Catherine J</creator><creator>Conron, Matthew</creator><creator>Munro, Prue</creator><creator>McDonald, Christine F</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>Small changes in six-minute walk distance are important in diffuse parenchymal lung disease</title><author>Holland, Anne E ; Hill, Catherine J ; Conron, Matthew ; Munro, Prue ; McDonald, Christine F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-d65a401f6cdd0e29cddbc5bb8415d34c57d4df41de678f5f3bf634016c0df54c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Confidence intervals</topic><topic>Disease</topic><topic>Exercise test</topic><topic>Exercise Test - methods</topic><topic>Exercise Therapy</topic><topic>Female</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Humans</topic><topic>Idiopathic Pulmonary Fibrosis - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Outcome assessment</topic><topic>Pneumology</topic><topic>Practice Guidelines as Topic</topic><topic>Pulmonary fibrosis</topic><topic>Pulmonary/Respiratory</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Studies</topic><topic>Time Factors</topic><topic>Walking</topic><topic>Walking - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holland, Anne E</creatorcontrib><creatorcontrib>Hill, Catherine J</creatorcontrib><creatorcontrib>Conron, Matthew</creatorcontrib><creatorcontrib>Munro, Prue</creatorcontrib><creatorcontrib>McDonald, Christine F</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holland, Anne E</au><au>Hill, Catherine J</au><au>Conron, Matthew</au><au>Munro, Prue</au><au>McDonald, Christine F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Small changes in six-minute walk distance are important in diffuse parenchymal lung disease</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>103</volume><issue>10</issue><spage>1430</spage><epage>1435</epage><pages>1430-1435</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Summary The aim of this study was to determine the minimal important difference for the six-minute walk distance in people with diffuse parenchymal lung disease. Methods Forty-eight subjects (24 idiopathic pulmonary fibrosis) undertook the six-minute walk test before and after an 8-week exercise program. The minimal important difference was calculated using a distribution-based and an anchor-based method. A global rating of change scale was used as the external criterion to judge patients as clinically unchanged or changed. Results The mean change in six-minute walk distance in improved subjects was 50.0 m, compared to 4.0 m in unchanged subjects and a reduction of 64.3 m in those classified as worse ( p < 0.001). The receiver operating characteristic curve indicated a cut-off value for meaningful change of 30.5 m (area under the curve 0.89, 95% confidence interval 0.81–0.98) whilst the standard error of the mean method indicated a value of 33 m. Similar values were obtained when only subjects with idiopathic pulmonary fibrosis were included (29 and 34 m, respectively). Conclusions Small differences in six-minute walk distance, in the range 29–34 m, may be clinically significant for people with diffuse parenchymal lung disease.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19477109</pmid><doi>10.1016/j.rmed.2009.04.024</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Analysis of Variance Area Under Curve Biological and medical sciences Confidence intervals Disease Exercise test Exercise Test - methods Exercise Therapy Female Forced Expiratory Volume - physiology Humans Idiopathic Pulmonary Fibrosis - physiopathology Male Medical sciences Methods Middle Aged Outcome assessment Pneumology Practice Guidelines as Topic Pulmonary fibrosis Pulmonary/Respiratory Respiratory system : syndromes and miscellaneous diseases Studies Time Factors Walking Walking - physiology |
| title | Small changes in six-minute walk distance are important in diffuse parenchymal lung disease |
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