P-selectin gene polymorphisms and risk of coronary heart disease among Tunisians
P-selectin plays a key role in inflammation and atherosclerosis, and polymorphic variants of P-selectin were implicated in the pathogenesis of atherosclerotic and inflammatory changes, including coronary heart disease (CHD) in many ethnic groups. We investigated the contribution of P-selectin promot...
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| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2009-10, Vol.28 (3), p.314-319 |
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| creator | Ghazouani, Lakhdar Abboud, Nesrine Khlifa, Sonia Bel-Hadj Perret, Claire Nicaud, Viviane Cambien, François Almawi, Wassim Y. Mahjoub, Touhami |
| description | P-selectin plays a key role in inflammation and atherosclerosis, and polymorphic variants of P-selectin were implicated in the pathogenesis of atherosclerotic and inflammatory changes, including coronary heart disease (CHD) in many ethnic groups. We investigated the contribution of P-selectin promoter (−2123C/G, −1969G/A) and exon (Ser290Asn, Asn562Asp, Thr715Pro) polymorphisms to CHD genetic susceptibility among 298 Tunisian CHD patients and 339 controls. Minor allele and genotype frequencies of the five P-selectin SNPs were comparable between patients and controls, except for −2123G/G genotype which was more frequent in cases. The 715Pro allele was present at lower frequency in Tunisians than in Europeans, and was not protective of CHD. Linkage disequilibrium was seen between −1969G/A, and both Ser290Asn and Asn562Asp. Five-loci haplotype analysis did not identify any CHD-protective or CHD-susceptible haplotypes. To our knowledge, this was the first case-control study to be performed on an Arab/North-African population, and demonstrates that none of the five P-selectin polymorphisms investigated influence CHD susceptibility in Tunisian Arabs. |
| doi_str_mv | 10.1007/s11239-008-0297-8 |
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We investigated the contribution of P-selectin promoter (−2123C/G, −1969G/A) and exon (Ser290Asn, Asn562Asp, Thr715Pro) polymorphisms to CHD genetic susceptibility among 298 Tunisian CHD patients and 339 controls. Minor allele and genotype frequencies of the five P-selectin SNPs were comparable between patients and controls, except for −2123G/G genotype which was more frequent in cases. The 715Pro allele was present at lower frequency in Tunisians than in Europeans, and was not protective of CHD. Linkage disequilibrium was seen between −1969G/A, and both Ser290Asn and Asn562Asp. Five-loci haplotype analysis did not identify any CHD-protective or CHD-susceptible haplotypes. To our knowledge, this was the first case-control study to be performed on an Arab/North-African population, and demonstrates that none of the five P-selectin polymorphisms investigated influence CHD susceptibility in Tunisian Arabs.</description><identifier>ISSN: 0929-5305</identifier><identifier>EISSN: 1573-742X</identifier><identifier>DOI: 10.1007/s11239-008-0297-8</identifier><identifier>PMID: 19082691</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Aged ; Cardiology ; Case-Control Studies ; Coronary Disease - epidemiology ; Coronary Disease - genetics ; Female ; Gene Frequency ; Genetic Predisposition to Disease - genetics ; Hematology ; Humans ; Linkage Disequilibrium ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; P-Selectin - genetics ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Risk ; Tunisia - epidemiology</subject><ispartof>Journal of thrombosis and thrombolysis, 2009-10, Vol.28 (3), p.314-319</ispartof><rights>Springer Science+Business Media, LLC 2008</rights><rights>Springer Science+Business Media, LLC 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-e8c634186983ebe93e1294897163b5f5977c1557f1287104fd4bdbdc59742f103</citedby><cites>FETCH-LOGICAL-c401t-e8c634186983ebe93e1294897163b5f5977c1557f1287104fd4bdbdc59742f103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11239-008-0297-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11239-008-0297-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19082691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghazouani, Lakhdar</creatorcontrib><creatorcontrib>Abboud, Nesrine</creatorcontrib><creatorcontrib>Khlifa, Sonia Bel-Hadj</creatorcontrib><creatorcontrib>Perret, Claire</creatorcontrib><creatorcontrib>Nicaud, Viviane</creatorcontrib><creatorcontrib>Cambien, François</creatorcontrib><creatorcontrib>Almawi, Wassim Y.</creatorcontrib><creatorcontrib>Mahjoub, Touhami</creatorcontrib><title>P-selectin gene polymorphisms and risk of coronary heart disease among Tunisians</title><title>Journal of thrombosis and thrombolysis</title><addtitle>J Thromb Thrombolysis</addtitle><addtitle>J Thromb Thrombolysis</addtitle><description>P-selectin plays a key role in inflammation and atherosclerosis, and polymorphic variants of P-selectin were implicated in the pathogenesis of atherosclerotic and inflammatory changes, including coronary heart disease (CHD) in many ethnic groups. We investigated the contribution of P-selectin promoter (−2123C/G, −1969G/A) and exon (Ser290Asn, Asn562Asp, Thr715Pro) polymorphisms to CHD genetic susceptibility among 298 Tunisian CHD patients and 339 controls. Minor allele and genotype frequencies of the five P-selectin SNPs were comparable between patients and controls, except for −2123G/G genotype which was more frequent in cases. The 715Pro allele was present at lower frequency in Tunisians than in Europeans, and was not protective of CHD. Linkage disequilibrium was seen between −1969G/A, and both Ser290Asn and Asn562Asp. Five-loci haplotype analysis did not identify any CHD-protective or CHD-susceptible haplotypes. To our knowledge, this was the first case-control study to be performed on an Arab/North-African population, and demonstrates that none of the five P-selectin polymorphisms investigated influence CHD susceptibility in Tunisian Arabs.</description><subject>Aged</subject><subject>Cardiology</subject><subject>Case-Control Studies</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary Disease - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Hematology</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>P-Selectin - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk</subject><subject>Tunisia - epidemiology</subject><issn>0929-5305</issn><issn>1573-742X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1rHDEMhk1paTab_oBeiumhPU0q2Z61fSwhbQqB5JBCbmY-NJtJZ-yttXPIv6_DLgQK7UkHPXqF9AjxHuEcAewXRlTaVwCuAuVt5V6JFdZWV9ao-9diBV75qtZQn4hT5kcA8B7UW3GCHpzaeFyJ29uKaaJuP0a5pUhyl6anOeXdw8gzyyb2Mo_8S6ZBdimn2OQn-UBN3st-ZGqYZDOnuJV3Sxx5bCKfiTdDMzG9O9a1-Pnt8u7iqrq--f7j4ut11RnAfUWu22iDbuOdppa8JlTeOG9xo9t6qL21Hda1HVA5i2CG3rR923elYdSAoNfi8yF3l9PvhXgf5pE7mqYmUlo4WG1AW1W-sRaf_ksqBAtWYwE__gU-piXHckVQCrTRCHWB8AB1OTFnGsIuj3N5S0AIz1bCwUooVsKzleDKzIdj8NLO1L9MHDUUQB0ALq24pfyy-d-pfwD8_5Xm</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Ghazouani, Lakhdar</creator><creator>Abboud, Nesrine</creator><creator>Khlifa, Sonia Bel-Hadj</creator><creator>Perret, Claire</creator><creator>Nicaud, Viviane</creator><creator>Cambien, François</creator><creator>Almawi, Wassim Y.</creator><creator>Mahjoub, Touhami</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20091001</creationdate><title>P-selectin gene polymorphisms and risk of coronary heart disease among Tunisians</title><author>Ghazouani, Lakhdar ; Abboud, Nesrine ; Khlifa, Sonia Bel-Hadj ; Perret, Claire ; Nicaud, Viviane ; Cambien, François ; Almawi, Wassim Y. ; Mahjoub, Touhami</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-e8c634186983ebe93e1294897163b5f5977c1557f1287104fd4bdbdc59742f103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Cardiology</topic><topic>Case-Control Studies</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary Disease - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Hematology</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>P-Selectin - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk</topic><topic>Tunisia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghazouani, Lakhdar</creatorcontrib><creatorcontrib>Abboud, Nesrine</creatorcontrib><creatorcontrib>Khlifa, Sonia Bel-Hadj</creatorcontrib><creatorcontrib>Perret, Claire</creatorcontrib><creatorcontrib>Nicaud, Viviane</creatorcontrib><creatorcontrib>Cambien, François</creatorcontrib><creatorcontrib>Almawi, Wassim Y.</creatorcontrib><creatorcontrib>Mahjoub, Touhami</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Complete (ProQuest Database)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and thrombolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghazouani, Lakhdar</au><au>Abboud, Nesrine</au><au>Khlifa, Sonia Bel-Hadj</au><au>Perret, Claire</au><au>Nicaud, Viviane</au><au>Cambien, François</au><au>Almawi, Wassim Y.</au><au>Mahjoub, Touhami</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>P-selectin gene polymorphisms and risk of coronary heart disease among Tunisians</atitle><jtitle>Journal of thrombosis and thrombolysis</jtitle><stitle>J Thromb Thrombolysis</stitle><addtitle>J Thromb Thrombolysis</addtitle><date>2009-10-01</date><risdate>2009</risdate><volume>28</volume><issue>3</issue><spage>314</spage><epage>319</epage><pages>314-319</pages><issn>0929-5305</issn><eissn>1573-742X</eissn><abstract>P-selectin plays a key role in inflammation and atherosclerosis, and polymorphic variants of P-selectin were implicated in the pathogenesis of atherosclerotic and inflammatory changes, including coronary heart disease (CHD) in many ethnic groups. We investigated the contribution of P-selectin promoter (−2123C/G, −1969G/A) and exon (Ser290Asn, Asn562Asp, Thr715Pro) polymorphisms to CHD genetic susceptibility among 298 Tunisian CHD patients and 339 controls. Minor allele and genotype frequencies of the five P-selectin SNPs were comparable between patients and controls, except for −2123G/G genotype which was more frequent in cases. The 715Pro allele was present at lower frequency in Tunisians than in Europeans, and was not protective of CHD. Linkage disequilibrium was seen between −1969G/A, and both Ser290Asn and Asn562Asp. Five-loci haplotype analysis did not identify any CHD-protective or CHD-susceptible haplotypes. To our knowledge, this was the first case-control study to be performed on an Arab/North-African population, and demonstrates that none of the five P-selectin polymorphisms investigated influence CHD susceptibility in Tunisian Arabs.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>19082691</pmid><doi>10.1007/s11239-008-0297-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Cardiology Case-Control Studies Coronary Disease - epidemiology Coronary Disease - genetics Female Gene Frequency Genetic Predisposition to Disease - genetics Hematology Humans Linkage Disequilibrium Male Medicine Medicine & Public Health Middle Aged P-Selectin - genetics Polymorphism, Genetic Polymorphism, Single Nucleotide Risk Tunisia - epidemiology |
| title | P-selectin gene polymorphisms and risk of coronary heart disease among Tunisians |
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