ADAM12s as a first-trimester screening marker of trisomy
Objective To evaluate the potential of maternal serum A Disintegrin And Metalloprotease 12‐S (ADAM12s) as an additional marker for the combined test in the Dutch first‐trimester national Down syndrome (DS) screening program. Methods Serum samples were collected between 2004 and 2007 as part of the n...
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| Veröffentlicht in: | Prenatal diagnosis 2009-09, Vol.29 (9), p.866-869 |
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| creator | Wortelboer, E. J. Linskens, I. H. Koster, M. P. H. Stoutenbeek, P. Cuckle, H. Blankenstein, M. A. Visser, G. H. A. van Vugt, J. M. G. Schielen, P. C. J. I. |
| description | Objective
To evaluate the potential of maternal serum A Disintegrin And Metalloprotease 12‐S (ADAM12s) as an additional marker for the combined test in the Dutch first‐trimester national Down syndrome (DS) screening program.
Methods
Serum samples were collected between 2004 and 2007 as part of the national program. A total of 218 singleton cases of trisomy 21 (DS), 62 trisomy 18 (Edwards syndrome) and 29 trisomy 13 (Patau syndrome) were identified. All cases were matched with controls for gestation, maternal weight and maternal age. The serum concentration of ADAM12s was determined ‘blind’ to outcome and expressed in multiples of the gestation‐specific median for controls (MoM).
Results
The median ADAM12s was 1.00 MoM in controls and in the DS cases at 8, 9, 10, 11, 12, 13 weeks it was 0.45 (n = 3), 0.73 (22), 0.74 (53), 0.85 (37), 0.92 (71), 1.06 (32) MoM, respectively. The median for trisomy 18 was 0.85 MoM and for trisomy 13 0.63 MoM.
Conclusion
The ADAM12s MoM values were clearly reduced in early first‐trimester for all trisomies. However, the screening performance for DS did not greatly improve adding ADAM12s. ADAM12s could be an additional biochemical marker for first‐trimester screening for trisomies other than DS. Copyright © 2009 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/pd.2300 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734037104</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734037104</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4170-d1367deaf4fcfe333e61d48462b3071f0c1c0f18ba9f126957c6adf2d98433633</originalsourceid><addsrcrecordid>eNp90UtLxDAQAOAgiq4P_AfSiyhIdSaTbdrj4lt8HXzhJWTTRKrtdk120f33RrboSSGQkHzMZGYY20TYRwB-MC73OQEssB5CIVPgnBZZDzCeKe_jClsN4TXCnBdyma1g0ReCF9Bj-eBocIU8JDquxFU-TNKJrxobJtYnwXhrR9XoJWm0f4sXrUvia2ib2TpbcroOdqPb19j9yfHd4Vl6eXN6fji4TI1ACWmJlMnSaieccZaIbIalyEXGhwQSHRg04DAf6sIhz4q-NJkuHS-LXBBlRGtsZx537Nv3afyWaqpgbF3rkW2nQUkSQBJBRLn7r8RYPnAiCb9BjW9D8NapcaxZ-1lE6ruhalyq74ZGudUFnQ4bW_66roMRbHdAB6Nr5_XIVOHHccwLyUUW3d7cfVS1nf2VT90edWnTua7iHD5_dByCyiTJvnq8PlUPT-Lq-fH2Qj3RF3EElzs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1028023370</pqid></control><display><type>article</type><title>ADAM12s as a first-trimester screening marker of trisomy</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Wortelboer, E. J. ; Linskens, I. H. ; Koster, M. P. H. ; Stoutenbeek, P. ; Cuckle, H. ; Blankenstein, M. A. ; Visser, G. H. A. ; van Vugt, J. M. G. ; Schielen, P. C. J. I.</creator><creatorcontrib>Wortelboer, E. J. ; Linskens, I. H. ; Koster, M. P. H. ; Stoutenbeek, P. ; Cuckle, H. ; Blankenstein, M. A. ; Visser, G. H. A. ; van Vugt, J. M. G. ; Schielen, P. C. J. I.</creatorcontrib><description>Objective
To evaluate the potential of maternal serum A Disintegrin And Metalloprotease 12‐S (ADAM12s) as an additional marker for the combined test in the Dutch first‐trimester national Down syndrome (DS) screening program.
Methods
Serum samples were collected between 2004 and 2007 as part of the national program. A total of 218 singleton cases of trisomy 21 (DS), 62 trisomy 18 (Edwards syndrome) and 29 trisomy 13 (Patau syndrome) were identified. All cases were matched with controls for gestation, maternal weight and maternal age. The serum concentration of ADAM12s was determined ‘blind’ to outcome and expressed in multiples of the gestation‐specific median for controls (MoM).
Results
The median ADAM12s was 1.00 MoM in controls and in the DS cases at 8, 9, 10, 11, 12, 13 weeks it was 0.45 (n = 3), 0.73 (22), 0.74 (53), 0.85 (37), 0.92 (71), 1.06 (32) MoM, respectively. The median for trisomy 18 was 0.85 MoM and for trisomy 13 0.63 MoM.
Conclusion
The ADAM12s MoM values were clearly reduced in early first‐trimester for all trisomies. However, the screening performance for DS did not greatly improve adding ADAM12s. ADAM12s could be an additional biochemical marker for first‐trimester screening for trisomies other than DS. Copyright © 2009 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0197-3851</identifier><identifier>ISSN: 1097-0223</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.2300</identifier><identifier>PMID: 19544290</identifier><identifier>CODEN: PRDIDM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>ADAM Proteins - analysis ; ADAM Proteins - blood ; ADAM12 Protein ; ADAM12s ; Adult ; Biochemical markers ; Biological and medical sciences ; Biomarkers - blood ; Chromosomes, Human, Pair 13 ; Chromosomes, Human, Pair 18 ; Chromosomes, Human, Pair 21 ; Delivery. Postpartum. Lactation ; Down Syndrome - diagnosis ; Down's syndrome ; Efficiency ; Female ; first-trimester combined test ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. Biological and molecular evolution ; Gestation ; Gynecology. Andrology. Obstetrics ; Humans ; Mass Screening - methods ; Medical sciences ; Membrane Proteins - analysis ; Membrane Proteins - blood ; Metalloproteinase ; Molecular and cellular biology ; Patau's syndrome ; Pregnancy ; Pregnancy Trimester, First - blood ; Prenatal diagnosis ; Prenatal Diagnosis - methods ; Protein Isoforms - analysis ; Protein Isoforms - blood ; Trisomy ; Trisomy - diagnosis ; trisomy 13 ; trisomy 18 ; trisomy 21</subject><ispartof>Prenatal diagnosis, 2009-09, Vol.29 (9), p.866-869</ispartof><rights>Copyright © 2009 John Wiley & Sons, Ltd.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4170-d1367deaf4fcfe333e61d48462b3071f0c1c0f18ba9f126957c6adf2d98433633</citedby><cites>FETCH-LOGICAL-c4170-d1367deaf4fcfe333e61d48462b3071f0c1c0f18ba9f126957c6adf2d98433633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.2300$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.2300$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21897246$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19544290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wortelboer, E. J.</creatorcontrib><creatorcontrib>Linskens, I. H.</creatorcontrib><creatorcontrib>Koster, M. P. H.</creatorcontrib><creatorcontrib>Stoutenbeek, P.</creatorcontrib><creatorcontrib>Cuckle, H.</creatorcontrib><creatorcontrib>Blankenstein, M. A.</creatorcontrib><creatorcontrib>Visser, G. H. A.</creatorcontrib><creatorcontrib>van Vugt, J. M. G.</creatorcontrib><creatorcontrib>Schielen, P. C. J. I.</creatorcontrib><title>ADAM12s as a first-trimester screening marker of trisomy</title><title>Prenatal diagnosis</title><addtitle>Prenat. Diagn</addtitle><description>Objective
To evaluate the potential of maternal serum A Disintegrin And Metalloprotease 12‐S (ADAM12s) as an additional marker for the combined test in the Dutch first‐trimester national Down syndrome (DS) screening program.
Methods
Serum samples were collected between 2004 and 2007 as part of the national program. A total of 218 singleton cases of trisomy 21 (DS), 62 trisomy 18 (Edwards syndrome) and 29 trisomy 13 (Patau syndrome) were identified. All cases were matched with controls for gestation, maternal weight and maternal age. The serum concentration of ADAM12s was determined ‘blind’ to outcome and expressed in multiples of the gestation‐specific median for controls (MoM).
Results
The median ADAM12s was 1.00 MoM in controls and in the DS cases at 8, 9, 10, 11, 12, 13 weeks it was 0.45 (n = 3), 0.73 (22), 0.74 (53), 0.85 (37), 0.92 (71), 1.06 (32) MoM, respectively. The median for trisomy 18 was 0.85 MoM and for trisomy 13 0.63 MoM.
Conclusion
The ADAM12s MoM values were clearly reduced in early first‐trimester for all trisomies. However, the screening performance for DS did not greatly improve adding ADAM12s. ADAM12s could be an additional biochemical marker for first‐trimester screening for trisomies other than DS. Copyright © 2009 John Wiley & Sons, Ltd.</description><subject>ADAM Proteins - analysis</subject><subject>ADAM Proteins - blood</subject><subject>ADAM12 Protein</subject><subject>ADAM12s</subject><subject>Adult</subject><subject>Biochemical markers</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Chromosomes, Human, Pair 13</subject><subject>Chromosomes, Human, Pair 18</subject><subject>Chromosomes, Human, Pair 21</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Down Syndrome - diagnosis</subject><subject>Down's syndrome</subject><subject>Efficiency</subject><subject>Female</subject><subject>first-trimester combined test</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Gestation</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Membrane Proteins - analysis</subject><subject>Membrane Proteins - blood</subject><subject>Metalloproteinase</subject><subject>Molecular and cellular biology</subject><subject>Patau's syndrome</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First - blood</subject><subject>Prenatal diagnosis</subject><subject>Prenatal Diagnosis - methods</subject><subject>Protein Isoforms - analysis</subject><subject>Protein Isoforms - blood</subject><subject>Trisomy</subject><subject>Trisomy - diagnosis</subject><subject>trisomy 13</subject><subject>trisomy 18</subject><subject>trisomy 21</subject><issn>0197-3851</issn><issn>1097-0223</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90UtLxDAQAOAgiq4P_AfSiyhIdSaTbdrj4lt8HXzhJWTTRKrtdk120f33RrboSSGQkHzMZGYY20TYRwB-MC73OQEssB5CIVPgnBZZDzCeKe_jClsN4TXCnBdyma1g0ReCF9Bj-eBocIU8JDquxFU-TNKJrxobJtYnwXhrR9XoJWm0f4sXrUvia2ib2TpbcroOdqPb19j9yfHd4Vl6eXN6fji4TI1ACWmJlMnSaieccZaIbIalyEXGhwQSHRg04DAf6sIhz4q-NJkuHS-LXBBlRGtsZx537Nv3afyWaqpgbF3rkW2nQUkSQBJBRLn7r8RYPnAiCb9BjW9D8NapcaxZ-1lE6ruhalyq74ZGudUFnQ4bW_66roMRbHdAB6Nr5_XIVOHHccwLyUUW3d7cfVS1nf2VT90edWnTua7iHD5_dByCyiTJvnq8PlUPT-Lq-fH2Qj3RF3EElzs</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Wortelboer, E. J.</creator><creator>Linskens, I. H.</creator><creator>Koster, M. P. H.</creator><creator>Stoutenbeek, P.</creator><creator>Cuckle, H.</creator><creator>Blankenstein, M. A.</creator><creator>Visser, G. H. A.</creator><creator>van Vugt, J. M. G.</creator><creator>Schielen, P. C. J. I.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>ADAM12s as a first-trimester screening marker of trisomy</title><author>Wortelboer, E. J. ; Linskens, I. H. ; Koster, M. P. H. ; Stoutenbeek, P. ; Cuckle, H. ; Blankenstein, M. A. ; Visser, G. H. A. ; van Vugt, J. M. G. ; Schielen, P. C. J. I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4170-d1367deaf4fcfe333e61d48462b3071f0c1c0f18ba9f126957c6adf2d98433633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>ADAM Proteins - analysis</topic><topic>ADAM Proteins - blood</topic><topic>ADAM12 Protein</topic><topic>ADAM12s</topic><topic>Adult</topic><topic>Biochemical markers</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Chromosomes, Human, Pair 13</topic><topic>Chromosomes, Human, Pair 18</topic><topic>Chromosomes, Human, Pair 21</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Down Syndrome - diagnosis</topic><topic>Down's syndrome</topic><topic>Efficiency</topic><topic>Female</topic><topic>first-trimester combined test</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Gestation</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Membrane Proteins - analysis</topic><topic>Membrane Proteins - blood</topic><topic>Metalloproteinase</topic><topic>Molecular and cellular biology</topic><topic>Patau's syndrome</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First - blood</topic><topic>Prenatal diagnosis</topic><topic>Prenatal Diagnosis - methods</topic><topic>Protein Isoforms - analysis</topic><topic>Protein Isoforms - blood</topic><topic>Trisomy</topic><topic>Trisomy - diagnosis</topic><topic>trisomy 13</topic><topic>trisomy 18</topic><topic>trisomy 21</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wortelboer, E. J.</creatorcontrib><creatorcontrib>Linskens, I. H.</creatorcontrib><creatorcontrib>Koster, M. P. H.</creatorcontrib><creatorcontrib>Stoutenbeek, P.</creatorcontrib><creatorcontrib>Cuckle, H.</creatorcontrib><creatorcontrib>Blankenstein, M. A.</creatorcontrib><creatorcontrib>Visser, G. H. A.</creatorcontrib><creatorcontrib>van Vugt, J. M. G.</creatorcontrib><creatorcontrib>Schielen, P. C. J. I.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wortelboer, E. J.</au><au>Linskens, I. H.</au><au>Koster, M. P. H.</au><au>Stoutenbeek, P.</au><au>Cuckle, H.</au><au>Blankenstein, M. A.</au><au>Visser, G. H. A.</au><au>van Vugt, J. M. G.</au><au>Schielen, P. C. J. I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ADAM12s as a first-trimester screening marker of trisomy</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat. Diagn</addtitle><date>2009-09</date><risdate>2009</risdate><volume>29</volume><issue>9</issue><spage>866</spage><epage>869</epage><pages>866-869</pages><issn>0197-3851</issn><issn>1097-0223</issn><eissn>1097-0223</eissn><coden>PRDIDM</coden><abstract>Objective
To evaluate the potential of maternal serum A Disintegrin And Metalloprotease 12‐S (ADAM12s) as an additional marker for the combined test in the Dutch first‐trimester national Down syndrome (DS) screening program.
Methods
Serum samples were collected between 2004 and 2007 as part of the national program. A total of 218 singleton cases of trisomy 21 (DS), 62 trisomy 18 (Edwards syndrome) and 29 trisomy 13 (Patau syndrome) were identified. All cases were matched with controls for gestation, maternal weight and maternal age. The serum concentration of ADAM12s was determined ‘blind’ to outcome and expressed in multiples of the gestation‐specific median for controls (MoM).
Results
The median ADAM12s was 1.00 MoM in controls and in the DS cases at 8, 9, 10, 11, 12, 13 weeks it was 0.45 (n = 3), 0.73 (22), 0.74 (53), 0.85 (37), 0.92 (71), 1.06 (32) MoM, respectively. The median for trisomy 18 was 0.85 MoM and for trisomy 13 0.63 MoM.
Conclusion
The ADAM12s MoM values were clearly reduced in early first‐trimester for all trisomies. However, the screening performance for DS did not greatly improve adding ADAM12s. ADAM12s could be an additional biochemical marker for first‐trimester screening for trisomies other than DS. Copyright © 2009 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19544290</pmid><doi>10.1002/pd.2300</doi><tpages>4</tpages></addata></record> |
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| subjects | ADAM Proteins - analysis ADAM Proteins - blood ADAM12 Protein ADAM12s Adult Biochemical markers Biological and medical sciences Biomarkers - blood Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 18 Chromosomes, Human, Pair 21 Delivery. Postpartum. Lactation Down Syndrome - diagnosis Down's syndrome Efficiency Female first-trimester combined test Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Gestation Gynecology. Andrology. Obstetrics Humans Mass Screening - methods Medical sciences Membrane Proteins - analysis Membrane Proteins - blood Metalloproteinase Molecular and cellular biology Patau's syndrome Pregnancy Pregnancy Trimester, First - blood Prenatal diagnosis Prenatal Diagnosis - methods Protein Isoforms - analysis Protein Isoforms - blood Trisomy Trisomy - diagnosis trisomy 13 trisomy 18 trisomy 21 |
| title | ADAM12s as a first-trimester screening marker of trisomy |
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