Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice
Purpose: Wedelia chinensis is a common ingredient of anti-inflammatory herbal medicines in Taiwan and southern China. Inflammation is involved in promoting tumor growth, invasion, and metastasis. This study aims to test the biological effects in vivo of W. chinensis extract on prostate cancer. Exper...
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| Veröffentlicht in: | Clinical cancer research 2009-09, Vol.15 (17), p.5435-5444 |
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| creator | TSAI, Chin-Hsien LIN, Feng-Min YANG, Yu-Chih LEE, Ming-Ting CHA, Tai-Lung WU, Guan-James HSIEH, Shih-Chuan HSIAO, Pei-Wen |
| description | Purpose: Wedelia chinensis is a common ingredient of anti-inflammatory herbal medicines in Taiwan and southern China. Inflammation is involved in promoting
tumor growth, invasion, and metastasis. This study aims to test the biological effects in vivo of W. chinensis extract on prostate cancer.
Experimental Design: The in vivo efficacy and mechanisms of action of oral administration of a standardized extract of W. chinensis were analyzed in animals bearing a subcutaneous or orthotopic prostate cancer xenograft.
Results: Exposure of prostate cancer cells to W. chinensis extract induced apoptosis selectively in androgen receptor (AR)–positive prostate cancer cells and shifted the proportion
in each phase of cell cycle toward G 2 -M phase in AR-negative prostate cancer cells. Oral herbal extract (4 or 40 mg/kg/d for 24-28 days) attenuated the growth
of prostate tumors in nude mice implanted at both subcutaneous (31% and 44%, respectively) and orthotopic (49% and 49%, respectively)
sites. The tumor suppression effects were associated with increased apoptosis and lower proliferation in tumor cells as well
as reduced tumor angiogenesis. The antitumor effect of W. chinensis extract was correlated with accumulation of the principle active compounds wedelolactone, luteolin, and apigenin in vivo .
Conclusion: Anticancer action of W. chinensis extract was due to three active compounds that inhibit the AR signaling pathway. Oral administration of W. chinensis extract impeded prostate cancer tumorigenesis. Future studies of W. chinensis for chemoprevention or complementary medicine against prostate cancer in humans are thus warranted. (Clin Cancer Res 2009;15(17):5435–44) |
| doi_str_mv | 10.1158/1078-0432.CCR-09-0298 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734035094</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734035094</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-f34d418b93a16bbef949076470ea320549a76ede53196fc366fa4e2da9eedfb13</originalsourceid><addsrcrecordid>eNpFkUFvFCEUx4nR2Fr9CBoupvEwLQwwsxw3k9o2qa1p2ngkDPPoYGZhBcbak19dprvqBd7h93-89wOh95ScUCpWp5S0q4pwVp903W1FZEVquXqBDqkQbcXqRrws9V_mAL1J6TshlFPCX6MDKhtJynGIfl9A7PWEz37lqE3GweJvMMDkNDaj8-CTS3idM_hZZyilH2J4AI9vwcA2h4jXJrufLj9h7Qd8E_MYctg6g89jeMzj0vBrDCmXNO60NxCx8_h6HgB_cQbeoldWTwne7e8jdP_57K67qK5uzi-79VVlWFvnyjI-cLrqJdO06XuwkkvSNrwloFlNBJe6bcrcgpWtrGFNYzWHetASYLA9ZUfoeNd3G8OPGVJWG5cMTJP2EOakWsYJE0TyQoodacrYKYJV2-g2Oj4pStSiXi1a1aJVFfWKSLWoL7kP-xfmfgPD_9TedQE-7gGdjJ5sLDZc-sfVNeXlg1jhPu240T2Mjy6CMs_eIiTQ0YyKCkVbJTgT7A_9F5vy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734035094</pqid></control><display><type>article</type><title>Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>TSAI, Chin-Hsien ; LIN, Feng-Min ; YANG, Yu-Chih ; LEE, Ming-Ting ; CHA, Tai-Lung ; WU, Guan-James ; HSIEH, Shih-Chuan ; HSIAO, Pei-Wen</creator><creatorcontrib>TSAI, Chin-Hsien ; LIN, Feng-Min ; YANG, Yu-Chih ; LEE, Ming-Ting ; CHA, Tai-Lung ; WU, Guan-James ; HSIEH, Shih-Chuan ; HSIAO, Pei-Wen</creatorcontrib><description>Purpose: Wedelia chinensis is a common ingredient of anti-inflammatory herbal medicines in Taiwan and southern China. Inflammation is involved in promoting
tumor growth, invasion, and metastasis. This study aims to test the biological effects in vivo of W. chinensis extract on prostate cancer.
Experimental Design: The in vivo efficacy and mechanisms of action of oral administration of a standardized extract of W. chinensis were analyzed in animals bearing a subcutaneous or orthotopic prostate cancer xenograft.
Results: Exposure of prostate cancer cells to W. chinensis extract induced apoptosis selectively in androgen receptor (AR)–positive prostate cancer cells and shifted the proportion
in each phase of cell cycle toward G 2 -M phase in AR-negative prostate cancer cells. Oral herbal extract (4 or 40 mg/kg/d for 24-28 days) attenuated the growth
of prostate tumors in nude mice implanted at both subcutaneous (31% and 44%, respectively) and orthotopic (49% and 49%, respectively)
sites. The tumor suppression effects were associated with increased apoptosis and lower proliferation in tumor cells as well
as reduced tumor angiogenesis. The antitumor effect of W. chinensis extract was correlated with accumulation of the principle active compounds wedelolactone, luteolin, and apigenin in vivo .
Conclusion: Anticancer action of W. chinensis extract was due to three active compounds that inhibit the AR signaling pathway. Oral administration of W. chinensis extract impeded prostate cancer tumorigenesis. Future studies of W. chinensis for chemoprevention or complementary medicine against prostate cancer in humans are thus warranted. (Clin Cancer Res 2009;15(17):5435–44)</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-09-0298</identifier><identifier>PMID: 19690196</identifier><identifier>CODEN: CCREF4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Administration, Oral ; Androgen Antagonists - pharmacology ; Androgen Antagonists - therapeutic use ; Androgen receptor ; Androgen Receptor Antagonists ; Animal models ; Animals ; Antineoplastic agents ; Apigenin - pharmacology ; Apigenin - therapeutic use ; Apoptosis ; Apoptosis - drug effects ; Apoptosis - physiology ; Biological and medical sciences ; Cell cycle ; Cell Cycle - drug effects ; Cell Cycle - physiology ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Coumarins - pharmacology ; Coumarins - therapeutic use ; Drugs, Chinese Herbal - pharmacology ; Drugs, Chinese Herbal - therapeutic use ; Gynecology. Andrology. Obstetrics ; Humans ; Luteolin - pharmacology ; Luteolin - therapeutic use ; Male ; Male genital diseases ; Medical sciences ; Mice ; Mice, Nude ; Natural products ; Neovascularization, Pathologic - drug therapy ; Nephrology. Urinary tract diseases ; Pharmacology. Drug treatments ; Phytotherapy ; Prostate cancer ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - pathology ; Receptors, Androgen - metabolism ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland ; Wedelia - chemistry ; Xenograft Model Antitumor Assays</subject><ispartof>Clinical cancer research, 2009-09, Vol.15 (17), p.5435-5444</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-f34d418b93a16bbef949076470ea320549a76ede53196fc366fa4e2da9eedfb13</citedby><cites>FETCH-LOGICAL-c372t-f34d418b93a16bbef949076470ea320549a76ede53196fc366fa4e2da9eedfb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,3343,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22140143$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19690196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TSAI, Chin-Hsien</creatorcontrib><creatorcontrib>LIN, Feng-Min</creatorcontrib><creatorcontrib>YANG, Yu-Chih</creatorcontrib><creatorcontrib>LEE, Ming-Ting</creatorcontrib><creatorcontrib>CHA, Tai-Lung</creatorcontrib><creatorcontrib>WU, Guan-James</creatorcontrib><creatorcontrib>HSIEH, Shih-Chuan</creatorcontrib><creatorcontrib>HSIAO, Pei-Wen</creatorcontrib><title>Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: Wedelia chinensis is a common ingredient of anti-inflammatory herbal medicines in Taiwan and southern China. Inflammation is involved in promoting
tumor growth, invasion, and metastasis. This study aims to test the biological effects in vivo of W. chinensis extract on prostate cancer.
Experimental Design: The in vivo efficacy and mechanisms of action of oral administration of a standardized extract of W. chinensis were analyzed in animals bearing a subcutaneous or orthotopic prostate cancer xenograft.
Results: Exposure of prostate cancer cells to W. chinensis extract induced apoptosis selectively in androgen receptor (AR)–positive prostate cancer cells and shifted the proportion
in each phase of cell cycle toward G 2 -M phase in AR-negative prostate cancer cells. Oral herbal extract (4 or 40 mg/kg/d for 24-28 days) attenuated the growth
of prostate tumors in nude mice implanted at both subcutaneous (31% and 44%, respectively) and orthotopic (49% and 49%, respectively)
sites. The tumor suppression effects were associated with increased apoptosis and lower proliferation in tumor cells as well
as reduced tumor angiogenesis. The antitumor effect of W. chinensis extract was correlated with accumulation of the principle active compounds wedelolactone, luteolin, and apigenin in vivo .
Conclusion: Anticancer action of W. chinensis extract was due to three active compounds that inhibit the AR signaling pathway. Oral administration of W. chinensis extract impeded prostate cancer tumorigenesis. Future studies of W. chinensis for chemoprevention or complementary medicine against prostate cancer in humans are thus warranted. (Clin Cancer Res 2009;15(17):5435–44)</description><subject>Administration, Oral</subject><subject>Androgen Antagonists - pharmacology</subject><subject>Androgen Antagonists - therapeutic use</subject><subject>Androgen receptor</subject><subject>Androgen Receptor Antagonists</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Apigenin - pharmacology</subject><subject>Apigenin - therapeutic use</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>Biological and medical sciences</subject><subject>Cell cycle</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Cycle - physiology</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Coumarins - pharmacology</subject><subject>Coumarins - therapeutic use</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Luteolin - pharmacology</subject><subject>Luteolin - therapeutic use</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Natural products</subject><subject>Neovascularization, Pathologic - drug therapy</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Receptors, Androgen - metabolism</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. Prostate gland</subject><subject>Wedelia - chemistry</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUFvFCEUx4nR2Fr9CBoupvEwLQwwsxw3k9o2qa1p2ngkDPPoYGZhBcbak19dprvqBd7h93-89wOh95ScUCpWp5S0q4pwVp903W1FZEVquXqBDqkQbcXqRrws9V_mAL1J6TshlFPCX6MDKhtJynGIfl9A7PWEz37lqE3GweJvMMDkNDaj8-CTS3idM_hZZyilH2J4AI9vwcA2h4jXJrufLj9h7Qd8E_MYctg6g89jeMzj0vBrDCmXNO60NxCx8_h6HgB_cQbeoldWTwne7e8jdP_57K67qK5uzi-79VVlWFvnyjI-cLrqJdO06XuwkkvSNrwloFlNBJe6bcrcgpWtrGFNYzWHetASYLA9ZUfoeNd3G8OPGVJWG5cMTJP2EOakWsYJE0TyQoodacrYKYJV2-g2Oj4pStSiXi1a1aJVFfWKSLWoL7kP-xfmfgPD_9TedQE-7gGdjJ5sLDZc-sfVNeXlg1jhPu240T2Mjy6CMs_eIiTQ0YyKCkVbJTgT7A_9F5vy</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>TSAI, Chin-Hsien</creator><creator>LIN, Feng-Min</creator><creator>YANG, Yu-Chih</creator><creator>LEE, Ming-Ting</creator><creator>CHA, Tai-Lung</creator><creator>WU, Guan-James</creator><creator>HSIEH, Shih-Chuan</creator><creator>HSIAO, Pei-Wen</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice</title><author>TSAI, Chin-Hsien ; LIN, Feng-Min ; YANG, Yu-Chih ; LEE, Ming-Ting ; CHA, Tai-Lung ; WU, Guan-James ; HSIEH, Shih-Chuan ; HSIAO, Pei-Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-f34d418b93a16bbef949076470ea320549a76ede53196fc366fa4e2da9eedfb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Administration, Oral</topic><topic>Androgen Antagonists - pharmacology</topic><topic>Androgen Antagonists - therapeutic use</topic><topic>Androgen receptor</topic><topic>Androgen Receptor Antagonists</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Apigenin - pharmacology</topic><topic>Apigenin - therapeutic use</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Apoptosis - physiology</topic><topic>Biological and medical sciences</topic><topic>Cell cycle</topic><topic>Cell Cycle - drug effects</topic><topic>Cell Cycle - physiology</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Coumarins - pharmacology</topic><topic>Coumarins - therapeutic use</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Luteolin - pharmacology</topic><topic>Luteolin - therapeutic use</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Natural products</topic><topic>Neovascularization, Pathologic - drug therapy</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Receptors, Androgen - metabolism</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. Prostate gland</topic><topic>Wedelia - chemistry</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TSAI, Chin-Hsien</creatorcontrib><creatorcontrib>LIN, Feng-Min</creatorcontrib><creatorcontrib>YANG, Yu-Chih</creatorcontrib><creatorcontrib>LEE, Ming-Ting</creatorcontrib><creatorcontrib>CHA, Tai-Lung</creatorcontrib><creatorcontrib>WU, Guan-James</creatorcontrib><creatorcontrib>HSIEH, Shih-Chuan</creatorcontrib><creatorcontrib>HSIAO, Pei-Wen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TSAI, Chin-Hsien</au><au>LIN, Feng-Min</au><au>YANG, Yu-Chih</au><au>LEE, Ming-Ting</au><au>CHA, Tai-Lung</au><au>WU, Guan-James</au><au>HSIEH, Shih-Chuan</au><au>HSIAO, Pei-Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>15</volume><issue>17</issue><spage>5435</spage><epage>5444</epage><pages>5435-5444</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><coden>CCREF4</coden><abstract>Purpose: Wedelia chinensis is a common ingredient of anti-inflammatory herbal medicines in Taiwan and southern China. Inflammation is involved in promoting
tumor growth, invasion, and metastasis. This study aims to test the biological effects in vivo of W. chinensis extract on prostate cancer.
Experimental Design: The in vivo efficacy and mechanisms of action of oral administration of a standardized extract of W. chinensis were analyzed in animals bearing a subcutaneous or orthotopic prostate cancer xenograft.
Results: Exposure of prostate cancer cells to W. chinensis extract induced apoptosis selectively in androgen receptor (AR)–positive prostate cancer cells and shifted the proportion
in each phase of cell cycle toward G 2 -M phase in AR-negative prostate cancer cells. Oral herbal extract (4 or 40 mg/kg/d for 24-28 days) attenuated the growth
of prostate tumors in nude mice implanted at both subcutaneous (31% and 44%, respectively) and orthotopic (49% and 49%, respectively)
sites. The tumor suppression effects were associated with increased apoptosis and lower proliferation in tumor cells as well
as reduced tumor angiogenesis. The antitumor effect of W. chinensis extract was correlated with accumulation of the principle active compounds wedelolactone, luteolin, and apigenin in vivo .
Conclusion: Anticancer action of W. chinensis extract was due to three active compounds that inhibit the AR signaling pathway. Oral administration of W. chinensis extract impeded prostate cancer tumorigenesis. Future studies of W. chinensis for chemoprevention or complementary medicine against prostate cancer in humans are thus warranted. (Clin Cancer Res 2009;15(17):5435–44)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>19690196</pmid><doi>10.1158/1078-0432.CCR-09-0298</doi><tpages>10</tpages></addata></record> |
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| issn | 1078-0432 1557-3265 |
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| subjects | Administration, Oral Androgen Antagonists - pharmacology Androgen Antagonists - therapeutic use Androgen receptor Androgen Receptor Antagonists Animal models Animals Antineoplastic agents Apigenin - pharmacology Apigenin - therapeutic use Apoptosis Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Cell cycle Cell Cycle - drug effects Cell Cycle - physiology Cell Line, Tumor Cell Proliferation - drug effects Coumarins - pharmacology Coumarins - therapeutic use Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Gynecology. Andrology. Obstetrics Humans Luteolin - pharmacology Luteolin - therapeutic use Male Male genital diseases Medical sciences Mice Mice, Nude Natural products Neovascularization, Pathologic - drug therapy Nephrology. Urinary tract diseases Pharmacology. Drug treatments Phytotherapy Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Receptors, Androgen - metabolism Tumors Tumors of the urinary system Urinary tract. Prostate gland Wedelia - chemistry Xenograft Model Antitumor Assays |
| title | Herbal Extract of Wedelia chinensis Attenuates Androgen Receptor Activity and Orthotopic Growth of Prostate Cancer in Nude Mice |
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