The Chiral Auxiliary N-1-(1′-Naphthyl)ethyl-O-tert-butylhydroxylamine: A Chiral Weinreb Amide Equivalent

The chiral auxiliary N-1-(1′-naphthyl)ethyl-O-tert-butylhydroxylamine is readily prepared from N-hydroxyphthalimide in four steps, with resolution giving access to both enantiomers in >98% ee, on a multigram (>25 g) scale. Conversion to a range of N-acyl derivatives, followed by highly diaster...

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Veröffentlicht in:	Organic letters 2009-08, Vol.11 (15), p.3254-3257
Hauptverfasser:	Chernega, Alexander N, Davies, Stephen G, Goodwin, Christopher J, Hepworth, David, Kurosawa, Wataru, Roberts, Paul M, Thomson, James E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Amides - chemistry Crystallography, X-Ray Hydroxylamine - chemistry Molecular Structure Naphthalenes - chemistry Stereoisomerism
Online-Zugang:	Volltext
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