Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents

The effect of substitution in the acyclic structure of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-thymine (HEPT) on anti-HIV-1 activity was investigated by synthesizing a series of deoxy analogs and related compounds. Preparation of 1-[(2-alkyloxyethoxy)methyl]-6- (phenylthio)thymine (2-4) derivativ...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-12, Vol.35 (25), p.4713-4719
Hauptverfasser:	Tanaka, Hiromichi, Takashima, Hideaki, Ubasawa, Masaru, Sekiya, Kouichi, Nitta, Issei, Baba, Masanori, Shigeta, Shiro, Walker, Richard T, De Clercq, Erik, Miyasaka, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Cells, Cultured Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings HIV-1 - drug effects Organic chemistry Preparations and properties Structure-Activity Relationship Thymine - analogs & derivatives Thymine - chemical synthesis Thymine - pharmacology Virus Replication - drug effects
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