Astragalosides Isolated from the Root of Astragalus Radix Inhibit the Formation of Advanced Glycation End Products
Because advanced glycation end product (AGE) inhibitors such as pyridoxamine significantly inhibit the development of retinopathy and neuropathy in the streptozotocin-induced diabetic rat, treatment with AGE inhibitors is believed to be a potential strategy for the prevention of lifestyle-related di...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2009-09, Vol.57 (17), p.7666-7672 |
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| container_issue | 17 |
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| container_title | Journal of agricultural and food chemistry |
| container_volume | 57 |
| creator | Motomura, Keita Fujiwara, Yukio Kiyota, Naoko Tsurushima, Keiichiro Takeya, Motohiro Nohara, Toshihiro Nagai, Ryoji Ikeda, Tsuyoshi |
| description | Because advanced glycation end product (AGE) inhibitors such as pyridoxamine significantly inhibit the development of retinopathy and neuropathy in the streptozotocin-induced diabetic rat, treatment with AGE inhibitors is believed to be a potential strategy for the prevention of lifestyle-related diseases such as diabetic complications. A crude extract of Astragali Radix (AR; roots of Astragalus membranaceus) inhibits the formation of N ε-(carboxymethyl)lysine (CML) and pentosidine during the incubation of bovine serum albumin with ribose. In the present study, compounds were isolated from AR that prevented CML and pentosidine formation. Astragalosides significantly inhibited the formation of both CML and pentosidine, and astragaloside V had the strongest inhibitory effect among all if the isolated compounds. These data suggest that AR and astragalosides may be a potentially useful strategy for the prevention of clinical diabetic complications by inhibiting AGEs. |
| doi_str_mv | 10.1021/jf9007168 |
| format | Article |
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A crude extract of Astragali Radix (AR; roots of Astragalus membranaceus) inhibits the formation of N ε-(carboxymethyl)lysine (CML) and pentosidine during the incubation of bovine serum albumin with ribose. In the present study, compounds were isolated from AR that prevented CML and pentosidine formation. Astragalosides significantly inhibited the formation of both CML and pentosidine, and astragaloside V had the strongest inhibitory effect among all if the isolated compounds. These data suggest that AR and astragalosides may be a potentially useful strategy for the prevention of clinical diabetic complications by inhibiting AGEs.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf9007168</identifier><identifier>PMID: 19681610</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject><![CDATA[Amadori products ; Arginine - analogs & derivatives ; Arginine - analysis ; Arginine - chemistry ; Astragalus membranaceus ; Astragalus Plant - chemistry ; Bioactive Constituents ; Biological and medical sciences ; bovine serum albumin ; carboxymethyl)lysine ; Diabetes Complications - prevention & control ; Food industries ; Fundamental and applied biological sciences. Psychology ; glycation ; Glycation End Products, Advanced - antagonists & inhibitors ; Lysine - analogs & derivatives ; Lysine - analysis ; Lysine - chemistry ; medicinal plants ; pentosidine ; plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; protective effect ; roots ; Saponins - isolation & purification ; Saponins - pharmacology ; Triterpenes - isolation & purification ; Triterpenes - pharmacology]]></subject><ispartof>Journal of agricultural and food chemistry, 2009-09, Vol.57 (17), p.7666-7672</ispartof><rights>Copyright © 2009 American Chemical Society</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a434t-75a76941e81a652eb47075b48e0426c2ecf584b7d25a7bd7f3583b8f93c7265d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf9007168$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf9007168$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27056,27904,27905,56718,56768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22077345$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19681610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motomura, Keita</creatorcontrib><creatorcontrib>Fujiwara, Yukio</creatorcontrib><creatorcontrib>Kiyota, Naoko</creatorcontrib><creatorcontrib>Tsurushima, Keiichiro</creatorcontrib><creatorcontrib>Takeya, Motohiro</creatorcontrib><creatorcontrib>Nohara, Toshihiro</creatorcontrib><creatorcontrib>Nagai, Ryoji</creatorcontrib><creatorcontrib>Ikeda, Tsuyoshi</creatorcontrib><title>Astragalosides Isolated from the Root of Astragalus Radix Inhibit the Formation of Advanced Glycation End Products</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Because advanced glycation end product (AGE) inhibitors such as pyridoxamine significantly inhibit the development of retinopathy and neuropathy in the streptozotocin-induced diabetic rat, treatment with AGE inhibitors is believed to be a potential strategy for the prevention of lifestyle-related diseases such as diabetic complications. A crude extract of Astragali Radix (AR; roots of Astragalus membranaceus) inhibits the formation of N ε-(carboxymethyl)lysine (CML) and pentosidine during the incubation of bovine serum albumin with ribose. In the present study, compounds were isolated from AR that prevented CML and pentosidine formation. Astragalosides significantly inhibited the formation of both CML and pentosidine, and astragaloside V had the strongest inhibitory effect among all if the isolated compounds. These data suggest that AR and astragalosides may be a potentially useful strategy for the prevention of clinical diabetic complications by inhibiting AGEs.</description><subject>Amadori products</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - analysis</subject><subject>Arginine - chemistry</subject><subject>Astragalus membranaceus</subject><subject>Astragalus Plant - chemistry</subject><subject>Bioactive Constituents</subject><subject>Biological and medical sciences</subject><subject>bovine serum albumin</subject><subject>carboxymethyl)lysine</subject><subject>Diabetes Complications - prevention & control</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glycation</subject><subject>Glycation End Products, Advanced - antagonists & inhibitors</subject><subject>Lysine - analogs & derivatives</subject><subject>Lysine - analysis</subject><subject>Lysine - chemistry</subject><subject>medicinal plants</subject><subject>pentosidine</subject><subject>plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots - chemistry</subject><subject>protective effect</subject><subject>roots</subject><subject>Saponins - isolation & purification</subject><subject>Saponins - pharmacology</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0MtO3DAUBmCrKoIpZdEXaL2pEIuU47tniRCXkZCooKwjxxfIKImp7aDy9rjMFDZdWTr-9J-jH6EvBH4QoOR4HZYAikj9AS2IoNAIQvRHtID62WghyR76lPMaALRQsIv2yFJqIgksUDrJJZl7M8TcO5_xKsfBFO9wSHHE5cHjmxgLjgH_g3PGN8b1f_Bqeui7vryi85hGU_o4vUr3ZCZbMy6GZ7uZnk0O_0zRzbbkz2gnmCH7g-27j-7Oz36dXjZX1xer05OrxnDGS6OEUXLJidfESEF9xxUo0XHtgVNpqbdBaN4pRyvsnApMaNbpsGRWUSkc20eHm9zHFH_PPpd27LP1w2AmH-fcKsaBccJklUcbaVPMOfnQPqZ-NOm5JdD-bbh9a7jar9vUuRu9e5fbSiv4vgUmWzOEVLvo85ujFFTdLKr7tnHBxNbcp2rubikQBkQqTYV6TzI2t-s4p6nW9Z-TXgBFcZd2</recordid><startdate>20090909</startdate><enddate>20090909</enddate><creator>Motomura, Keita</creator><creator>Fujiwara, Yukio</creator><creator>Kiyota, Naoko</creator><creator>Tsurushima, Keiichiro</creator><creator>Takeya, Motohiro</creator><creator>Nohara, Toshihiro</creator><creator>Nagai, Ryoji</creator><creator>Ikeda, Tsuyoshi</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090909</creationdate><title>Astragalosides Isolated from the Root of Astragalus Radix Inhibit the Formation of Advanced Glycation End Products</title><author>Motomura, Keita ; Fujiwara, Yukio ; Kiyota, Naoko ; Tsurushima, Keiichiro ; Takeya, Motohiro ; Nohara, Toshihiro ; Nagai, Ryoji ; Ikeda, Tsuyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a434t-75a76941e81a652eb47075b48e0426c2ecf584b7d25a7bd7f3583b8f93c7265d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Amadori products</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - analysis</topic><topic>Arginine - chemistry</topic><topic>Astragalus membranaceus</topic><topic>Astragalus Plant - chemistry</topic><topic>Bioactive Constituents</topic><topic>Biological and medical sciences</topic><topic>bovine serum albumin</topic><topic>carboxymethyl)lysine</topic><topic>Diabetes Complications - prevention & control</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>glycation</topic><topic>Glycation End Products, Advanced - antagonists & inhibitors</topic><topic>Lysine - analogs & derivatives</topic><topic>Lysine - analysis</topic><topic>Lysine - chemistry</topic><topic>medicinal plants</topic><topic>pentosidine</topic><topic>plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots - chemistry</topic><topic>protective effect</topic><topic>roots</topic><topic>Saponins - isolation & purification</topic><topic>Saponins - pharmacology</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motomura, Keita</creatorcontrib><creatorcontrib>Fujiwara, Yukio</creatorcontrib><creatorcontrib>Kiyota, Naoko</creatorcontrib><creatorcontrib>Tsurushima, Keiichiro</creatorcontrib><creatorcontrib>Takeya, Motohiro</creatorcontrib><creatorcontrib>Nohara, Toshihiro</creatorcontrib><creatorcontrib>Nagai, Ryoji</creatorcontrib><creatorcontrib>Ikeda, Tsuyoshi</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motomura, Keita</au><au>Fujiwara, Yukio</au><au>Kiyota, Naoko</au><au>Tsurushima, Keiichiro</au><au>Takeya, Motohiro</au><au>Nohara, Toshihiro</au><au>Nagai, Ryoji</au><au>Ikeda, Tsuyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Astragalosides Isolated from the Root of Astragalus Radix Inhibit the Formation of Advanced Glycation End Products</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2009-09-09</date><risdate>2009</risdate><volume>57</volume><issue>17</issue><spage>7666</spage><epage>7672</epage><pages>7666-7672</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Because advanced glycation end product (AGE) inhibitors such as pyridoxamine significantly inhibit the development of retinopathy and neuropathy in the streptozotocin-induced diabetic rat, treatment with AGE inhibitors is believed to be a potential strategy for the prevention of lifestyle-related diseases such as diabetic complications. A crude extract of Astragali Radix (AR; roots of Astragalus membranaceus) inhibits the formation of N ε-(carboxymethyl)lysine (CML) and pentosidine during the incubation of bovine serum albumin with ribose. In the present study, compounds were isolated from AR that prevented CML and pentosidine formation. Astragalosides significantly inhibited the formation of both CML and pentosidine, and astragaloside V had the strongest inhibitory effect among all if the isolated compounds. These data suggest that AR and astragalosides may be a potentially useful strategy for the prevention of clinical diabetic complications by inhibiting AGEs.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>19681610</pmid><doi>10.1021/jf9007168</doi><tpages>7</tpages></addata></record> |
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| subjects | Amadori products Arginine - analogs & derivatives Arginine - analysis Arginine - chemistry Astragalus membranaceus Astragalus Plant - chemistry Bioactive Constituents Biological and medical sciences bovine serum albumin carboxymethyl)lysine Diabetes Complications - prevention & control Food industries Fundamental and applied biological sciences. Psychology glycation Glycation End Products, Advanced - antagonists & inhibitors Lysine - analogs & derivatives Lysine - analysis Lysine - chemistry medicinal plants pentosidine plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry protective effect roots Saponins - isolation & purification Saponins - pharmacology Triterpenes - isolation & purification Triterpenes - pharmacology |
| title | Astragalosides Isolated from the Root of Astragalus Radix Inhibit the Formation of Advanced Glycation End Products |
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