Reduced Insulin Secretion in Protein Malnourished Mice Is Associated with Multiple Changes in the β-Cell Stimulus-Secretion Coupling

The mechanism by which protein malnutrition impairs glucose-stimulated insulin secretion in the pancreatic β-cell is not completely known but may be related to alterations in the signaling events involved in insulin release. Here, we aimed to study the stimulus-secretion coupling of β-cells from mic...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2010-08, Vol.151 (8), p.3543-3554
Hauptverfasser:	Soriano, Sergi, Gonzalez, Alejandro, Marroquí, Laura, Tudurí, Eva, Vieira, Elaine, Amaral, Andressa G, Batista, Thiago M, Rafacho, Alex, Boschero, Antonio C, Nadal, Angel, Carneiro, Everardo M, Quesada, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Beta cells Body Weight - drug effects Calcium (intracellular) Calcium ions Calcium signalling Cells, Cultured Channel gating Confocal microscopy Connexin 36 Coupling Depolarization Diet Diet, Protein-Restricted - adverse effects Dietary Proteins - pharmacology Down-Regulation - drug effects Down-Regulation - physiology Electric Capacitance Fasting - metabolism Fasting - physiology Fluorescence microscopy Glucose Glucose - metabolism Glucose - pharmacology Glucose - physiology Homeostasis - drug effects Insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Low protein diet Male Malnutrition Membrane potential Mice Microscopy Nutrient deficiency Pancreas Patch-Clamp Techniques Protein-Energy Malnutrition - metabolism Protein-Energy Malnutrition - pathology Proteins Secretory Pathway - drug effects Secretory Pathway - physiology Stimulation, Chemical Stimulus-secretion coupling Weaning
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