Prognostic value of mucin 4 expression in colorectal adenocarcinomas
BACKGROUND: Mucin 4 (MUC4) is aberrantly expressed in colorectal adenocarcinomas (CRCs) but its prognostic value is unknown. METHODS: Archival tissue specimens collected from 132 CRC patients who underwent surgical resection without presurgery or postsurgery therapy were evaluated for expression of...
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| Veröffentlicht in: | Cancer 2010-08, Vol.116 (15), p.3577-3586 |
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| creator | Shanmugam, Chandrakumar Jhala, Nirag C. Katkoori, Venkat R. Wan, Wen Meleth, Sreelatha Grizzle, William E. Manne, Upender |
| description | BACKGROUND:
Mucin 4 (MUC4) is aberrantly expressed in colorectal adenocarcinomas (CRCs) but its prognostic value is unknown.
METHODS:
Archival tissue specimens collected from 132 CRC patients who underwent surgical resection without presurgery or postsurgery therapy were evaluated for expression of MUC4 by using a mouse monoclonal antibody and horseradish peroxidase. MUC4 expression levels were correlated with clinicopathologic features and patient survival. Survival was estimated by both univariate Kaplan‐Meier and multivariate Cox regression methods.
RESULTS:
In both normal colonic epithelium and CRCs, MUC4 staining was localized primarily in the cytoplasm. The optimal immunostaining cutoff value (≥75% positive cells and an immunostaining score ≥2.0), which was derived by using the bootstrap method, was used to categorize CRCs into groups of high expression (33 of 132 patients; 25%) or low expression (99 of 132 patients; 75%). Patients who had early stage tumors (stages I and II) with high MUC4 expression had a shorter disease‐specific survival (log‐rank; P = .007) than patients who had with low expression. Patients who had advanced‐stage CRCs (stages III and IV) did not demonstrate such a difference (log‐rank; P = .108). Multivariate regression models that were generated separately for patients with early stage and advanced‐stage CRC confirmed that increased expression of MUC4 was an independent indicator of a poor prognosis only for patients who had early stage CRCs (hazard ratio, 3.77; 95% confidence interval, 1.46‐9.73).
CONCLUSIONS:
The current results indicated that increased MUC4 expression is a predictor of poor survival in CRC, specifically for patients who have early stage tumors. Cancer 2010. © 2010 American Cancer Society.
Aberrant expression of mucin 4 (MUC4) in colorectal adenocarcinoma was reported previously, but its prognostic value is not determined. Therefore, for the first time, the authors report their observation that increased expression of MUC4 is an independent prognostic marker in colorectal adenocarcinomas. |
| doi_str_mv | 10.1002/cncr.25095 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734031373</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734031373</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4605-a4b8f318b36b07116949160d87ad2b318ead6b0e65cd27e4391bdd1fb77007043</originalsourceid><addsrcrecordid>eNp90E1LxDAQBuAgiruuXvwB0osIQtdJkzTbo9RPEBVR8BbSJJVK2qzJVt1_b9auevM0DPMwM7wI7WOYYoDsRHXKTzMGBdtAYwwFTwHTbBONAWCWMkqeR2gnhNfY8oyRbTTKgOUUOB2js3vvXjoXFo1K3qXtTeLqpO1V0yU0MZ9zb0JoXJfEXjnrvFELaROpTeeU9JG5VoZdtFVLG8zeuk7Q08X5Y3mV3txdXpenN6miObBU0mpWEzyrSF4BxzgvaIFz0DMudVbFgZE6TkzOlM64oaTAlda4rjiPnwMlE3Q07J1799absBBtE5SxVnbG9UFwQoFgwkmUx4NU3oXgTS3mvmmlXwoMYhWaWIUmvkOL-GC9tq9ao3_pT0oRHK6BDEra2stONeHPEaB5xnh0eHAfjTXLf06K8rZ8GI5_AR61g0s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734031373</pqid></control><display><type>article</type><title>Prognostic value of mucin 4 expression in colorectal adenocarcinomas</title><source>MEDLINE</source><source>Wiley Online Library Free Content</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Shanmugam, Chandrakumar ; Jhala, Nirag C. ; Katkoori, Venkat R. ; Wan, Wen ; Meleth, Sreelatha ; Grizzle, William E. ; Manne, Upender</creator><creatorcontrib>Shanmugam, Chandrakumar ; Jhala, Nirag C. ; Katkoori, Venkat R. ; Wan, Wen ; Meleth, Sreelatha ; Grizzle, William E. ; Manne, Upender</creatorcontrib><description>BACKGROUND:
Mucin 4 (MUC4) is aberrantly expressed in colorectal adenocarcinomas (CRCs) but its prognostic value is unknown.
METHODS:
Archival tissue specimens collected from 132 CRC patients who underwent surgical resection without presurgery or postsurgery therapy were evaluated for expression of MUC4 by using a mouse monoclonal antibody and horseradish peroxidase. MUC4 expression levels were correlated with clinicopathologic features and patient survival. Survival was estimated by both univariate Kaplan‐Meier and multivariate Cox regression methods.
RESULTS:
In both normal colonic epithelium and CRCs, MUC4 staining was localized primarily in the cytoplasm. The optimal immunostaining cutoff value (≥75% positive cells and an immunostaining score ≥2.0), which was derived by using the bootstrap method, was used to categorize CRCs into groups of high expression (33 of 132 patients; 25%) or low expression (99 of 132 patients; 75%). Patients who had early stage tumors (stages I and II) with high MUC4 expression had a shorter disease‐specific survival (log‐rank; P = .007) than patients who had with low expression. Patients who had advanced‐stage CRCs (stages III and IV) did not demonstrate such a difference (log‐rank; P = .108). Multivariate regression models that were generated separately for patients with early stage and advanced‐stage CRC confirmed that increased expression of MUC4 was an independent indicator of a poor prognosis only for patients who had early stage CRCs (hazard ratio, 3.77; 95% confidence interval, 1.46‐9.73).
CONCLUSIONS:
The current results indicated that increased MUC4 expression is a predictor of poor survival in CRC, specifically for patients who have early stage tumors. Cancer 2010. © 2010 American Cancer Society.
Aberrant expression of mucin 4 (MUC4) in colorectal adenocarcinoma was reported previously, but its prognostic value is not determined. Therefore, for the first time, the authors report their observation that increased expression of MUC4 is an independent prognostic marker in colorectal adenocarcinomas.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.25095</identifier><identifier>PMID: 20564074</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - metabolism ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Aged ; Biological and medical sciences ; colorectal adenocarcinomas ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; early stage ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Male ; Medical sciences ; Mucin-4 ; Prognosis ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; survival ; Tumors</subject><ispartof>Cancer, 2010-08, Vol.116 (15), p.3577-3586</ispartof><rights>Copyright © 2010 American Cancer Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4605-a4b8f318b36b07116949160d87ad2b318ead6b0e65cd27e4391bdd1fb77007043</citedby><cites>FETCH-LOGICAL-c4605-a4b8f318b36b07116949160d87ad2b318ead6b0e65cd27e4391bdd1fb77007043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.25095$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.25095$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27928,27929,45578,45579,46413,46837</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23046257$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20564074$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shanmugam, Chandrakumar</creatorcontrib><creatorcontrib>Jhala, Nirag C.</creatorcontrib><creatorcontrib>Katkoori, Venkat R.</creatorcontrib><creatorcontrib>Wan, Wen</creatorcontrib><creatorcontrib>Meleth, Sreelatha</creatorcontrib><creatorcontrib>Grizzle, William E.</creatorcontrib><creatorcontrib>Manne, Upender</creatorcontrib><title>Prognostic value of mucin 4 expression in colorectal adenocarcinomas</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND:
Mucin 4 (MUC4) is aberrantly expressed in colorectal adenocarcinomas (CRCs) but its prognostic value is unknown.
METHODS:
Archival tissue specimens collected from 132 CRC patients who underwent surgical resection without presurgery or postsurgery therapy were evaluated for expression of MUC4 by using a mouse monoclonal antibody and horseradish peroxidase. MUC4 expression levels were correlated with clinicopathologic features and patient survival. Survival was estimated by both univariate Kaplan‐Meier and multivariate Cox regression methods.
RESULTS:
In both normal colonic epithelium and CRCs, MUC4 staining was localized primarily in the cytoplasm. The optimal immunostaining cutoff value (≥75% positive cells and an immunostaining score ≥2.0), which was derived by using the bootstrap method, was used to categorize CRCs into groups of high expression (33 of 132 patients; 25%) or low expression (99 of 132 patients; 75%). Patients who had early stage tumors (stages I and II) with high MUC4 expression had a shorter disease‐specific survival (log‐rank; P = .007) than patients who had with low expression. Patients who had advanced‐stage CRCs (stages III and IV) did not demonstrate such a difference (log‐rank; P = .108). Multivariate regression models that were generated separately for patients with early stage and advanced‐stage CRC confirmed that increased expression of MUC4 was an independent indicator of a poor prognosis only for patients who had early stage CRCs (hazard ratio, 3.77; 95% confidence interval, 1.46‐9.73).
CONCLUSIONS:
The current results indicated that increased MUC4 expression is a predictor of poor survival in CRC, specifically for patients who have early stage tumors. Cancer 2010. © 2010 American Cancer Society.
Aberrant expression of mucin 4 (MUC4) in colorectal adenocarcinoma was reported previously, but its prognostic value is not determined. Therefore, for the first time, the authors report their observation that increased expression of MUC4 is an independent prognostic marker in colorectal adenocarcinomas.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>colorectal adenocarcinomas</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>early stage</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mucin-4</subject><subject>Prognosis</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>survival</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1LxDAQBuAgiruuXvwB0osIQtdJkzTbo9RPEBVR8BbSJJVK2qzJVt1_b9auevM0DPMwM7wI7WOYYoDsRHXKTzMGBdtAYwwFTwHTbBONAWCWMkqeR2gnhNfY8oyRbTTKgOUUOB2js3vvXjoXFo1K3qXtTeLqpO1V0yU0MZ9zb0JoXJfEXjnrvFELaROpTeeU9JG5VoZdtFVLG8zeuk7Q08X5Y3mV3txdXpenN6miObBU0mpWEzyrSF4BxzgvaIFz0DMudVbFgZE6TkzOlM64oaTAlda4rjiPnwMlE3Q07J1799absBBtE5SxVnbG9UFwQoFgwkmUx4NU3oXgTS3mvmmlXwoMYhWaWIUmvkOL-GC9tq9ao3_pT0oRHK6BDEra2stONeHPEaB5xnh0eHAfjTXLf06K8rZ8GI5_AR61g0s</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Shanmugam, Chandrakumar</creator><creator>Jhala, Nirag C.</creator><creator>Katkoori, Venkat R.</creator><creator>Wan, Wen</creator><creator>Meleth, Sreelatha</creator><creator>Grizzle, William E.</creator><creator>Manne, Upender</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>Prognostic value of mucin 4 expression in colorectal adenocarcinomas</title><author>Shanmugam, Chandrakumar ; Jhala, Nirag C. ; Katkoori, Venkat R. ; Wan, Wen ; Meleth, Sreelatha ; Grizzle, William E. ; Manne, Upender</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4605-a4b8f318b36b07116949160d87ad2b318ead6b0e65cd27e4391bdd1fb77007043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>colorectal adenocarcinomas</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>early stage</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mucin-4</topic><topic>Prognosis</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>survival</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shanmugam, Chandrakumar</creatorcontrib><creatorcontrib>Jhala, Nirag C.</creatorcontrib><creatorcontrib>Katkoori, Venkat R.</creatorcontrib><creatorcontrib>Wan, Wen</creatorcontrib><creatorcontrib>Meleth, Sreelatha</creatorcontrib><creatorcontrib>Grizzle, William E.</creatorcontrib><creatorcontrib>Manne, Upender</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shanmugam, Chandrakumar</au><au>Jhala, Nirag C.</au><au>Katkoori, Venkat R.</au><au>Wan, Wen</au><au>Meleth, Sreelatha</au><au>Grizzle, William E.</au><au>Manne, Upender</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of mucin 4 expression in colorectal adenocarcinomas</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>116</volume><issue>15</issue><spage>3577</spage><epage>3586</epage><pages>3577-3586</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND:
Mucin 4 (MUC4) is aberrantly expressed in colorectal adenocarcinomas (CRCs) but its prognostic value is unknown.
METHODS:
Archival tissue specimens collected from 132 CRC patients who underwent surgical resection without presurgery or postsurgery therapy were evaluated for expression of MUC4 by using a mouse monoclonal antibody and horseradish peroxidase. MUC4 expression levels were correlated with clinicopathologic features and patient survival. Survival was estimated by both univariate Kaplan‐Meier and multivariate Cox regression methods.
RESULTS:
In both normal colonic epithelium and CRCs, MUC4 staining was localized primarily in the cytoplasm. The optimal immunostaining cutoff value (≥75% positive cells and an immunostaining score ≥2.0), which was derived by using the bootstrap method, was used to categorize CRCs into groups of high expression (33 of 132 patients; 25%) or low expression (99 of 132 patients; 75%). Patients who had early stage tumors (stages I and II) with high MUC4 expression had a shorter disease‐specific survival (log‐rank; P = .007) than patients who had with low expression. Patients who had advanced‐stage CRCs (stages III and IV) did not demonstrate such a difference (log‐rank; P = .108). Multivariate regression models that were generated separately for patients with early stage and advanced‐stage CRC confirmed that increased expression of MUC4 was an independent indicator of a poor prognosis only for patients who had early stage CRCs (hazard ratio, 3.77; 95% confidence interval, 1.46‐9.73).
CONCLUSIONS:
The current results indicated that increased MUC4 expression is a predictor of poor survival in CRC, specifically for patients who have early stage tumors. Cancer 2010. © 2010 American Cancer Society.
Aberrant expression of mucin 4 (MUC4) in colorectal adenocarcinoma was reported previously, but its prognostic value is not determined. Therefore, for the first time, the authors report their observation that increased expression of MUC4 is an independent prognostic marker in colorectal adenocarcinomas.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20564074</pmid><doi>10.1002/cncr.25095</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology Aged Biological and medical sciences colorectal adenocarcinomas Colorectal Neoplasms - diagnosis Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology early stage Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Mucin-4 Prognosis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus survival Tumors |
| title | Prognostic value of mucin 4 expression in colorectal adenocarcinomas |
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