Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the stromal cell-derived factor-1 alpha/CXCL12 chemokine

Stimulation of T lymphocytes with the ligand for the CXCR4 chemokine receptor stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12), results in prolonged activation of the extracellular signal-regulated kinases (ERK) ERK1 and ERK2. Because SDF-1alpha is unique among several chemokines in its abilit...

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Veröffentlicht in:	The Journal of immunology (1950) 2003-07, Vol.171 (1), p.360-367
Hauptverfasser:	Kremer, Kimberly N, Humphreys, Troy D, Kumar, Ashok, Qian, Nan-Xin, Hedin, Karen E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Binding Sites - genetics Binding Sites - immunology Carrier Proteins - metabolism Chemokine CXCL12 Chemokines, CXC - physiology Enzyme Activation - genetics Enzyme Activation - immunology Humans Jurkat Cells Lymphocyte Activation - genetics Membrane Proteins Mitogen-Activated Protein Kinases - metabolism Phosphoproteins - deficiency Phosphoproteins - genetics Phosphoproteins - metabolism Phosphoproteins - physiology Phosphorylation Protein Binding - genetics Protein Binding - immunology Protein-Tyrosine Kinases - deficiency Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - physiology Signal Transduction - genetics Signal Transduction - immunology src Homology Domains - genetics src Homology Domains - immunology Substrate Specificity - genetics Substrate Specificity - immunology T-Lymphocytes - enzymology T-Lymphocytes - immunology Tyrosine - metabolism ZAP-70 Protein-Tyrosine Kinase
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