Evaluation of serum iohexol clearance for use in predicting carboplatin clearance in cats

To determine whether a glomerular filtration rate (GFR) assay based on serum iohexol clearance can be used to predict carboplatin clearance in cats. 10 cats with tumors. GFR was measured concurrently by use of plasma clearance of technetium Tc 99m-labeled diethylenetriaminepentaacetic acid ((99m)Tc-...

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Veröffentlicht in:	American journal of veterinary research 2009-09, Vol.70 (9), p.1135-1140
Hauptverfasser:	Bailey, Dennis B, Rassnick, Kenneth M, Prey, Joshua D, Dykes, Nathan L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antineoplastic agents Area Under Curve bioassays biomarkers blood serum Body Surface Area Body Weight carboplatin Carboplatin - blood Carboplatin - metabolism Carcinoma - drug therapy Carcinoma - physiopathology Carcinoma - veterinary cat diseases Cat Diseases - drug therapy Cat Diseases - physiopathology cats Cats - metabolism chemotherapy Chromatography, High Pressure Liquid contrast agents dosage dose response drug evaluation drug excretion dyes glomerular filtration rate Glomerular Filtration Rate - physiology iohexal Iohexol - metabolism kidneys Metabolic Clearance Rate neoplasms pharmacokinetics prediction renal clearance Sarcoma - drug therapy Sarcoma - physiopathology Sarcoma - veterinary Technetium Tc 99m Pentetate - pharmacokinetics validity
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