Human CETP aggravates atherosclerosis by increasing VLDL-cholesterol rather than by decreasing HDL-cholesterol in APOE3-Leiden mice

Abstract Objective Cholesteryl ester transfer protein (CETP) adversely affects the plasma lipoprotein profile by increasing VLDL-cholesterol and decreasing HDL-cholesterol. The relative contribution of either of these changes to atherosclerosis development is not known. We investigated to what exten...

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Veröffentlicht in:	Atherosclerosis 2009-09, Vol.206 (1), p.153-158
Hauptverfasser:	de Vries-van der Weij, Jitske, Zadelaar, Susanne, Toet, Karin, Havekes, Louis M, Kooistra, Teake, Rensen, Patrick C.N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - genetics Atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - pathology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Cardiovascular system Cholesterol Ester Transfer Proteins - pharmacology Cholesterol, HDL - blood Cholesterol, VLDL - blood Cholesteryl ester transfer protein E-Selectin - blood Female Fibrinogen - metabolism Humans Inflammation - blood Lesion stability Lipoproteins Medical sciences Mice Pharmacology. Drug treatments Serum Amyloid A Protein - metabolism Vasodilator agents. Cerebral vasodilators
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