Carbapenem-resistant Klebsiella pneumoniae endocarditis in a young adult. Successful treatment with gentamicin and colistin
Enterobacteriaceae are rarely the etiologic agents of endocarditis, with Klebsiella species being especially rare. From the end of 2005, isolates of carbapenem-resistant Klebsiella pneumoniae began to appear in various hospitals across Israel, sensitive only to colistin and gentamicin. We present a...
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| Veröffentlicht in: | International journal of infectious diseases 2009-09, Vol.13 (5), p.e295-e298 |
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| container_title | International journal of infectious diseases |
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| creator | Benenson, Shmuel Navon-Venezia, Shiri Carmeli, Yehuda Adler, Amos Strahilevitz, Jacob Moses, Allon E Block, Colin |
| description | Enterobacteriaceae are rarely the etiologic agents of endocarditis, with Klebsiella species being especially rare. From the end of 2005, isolates of carbapenem-resistant Klebsiella pneumoniae began to appear in various hospitals across Israel, sensitive only to colistin and gentamicin. We present a case of hospital-acquired endocarditis caused by carbapenem-resistant K. pneumoniae in a young adult.
An 18-year-old man with 40% full thickness burns developed acute bacterial endocarditis complicated by embolic myocardial infarction. Carbapenem-resistant K. pneumoniae carrying the blaKPC3 gene was isolated from multiple blood cultures. He recovered fully after antibiotic treatment with colistin and gentamicin.
To our knowledge, this is the first reported case of acute bacterial endocarditis caused by carbapenem-resistant K. pneumoniae. The combination of intravenous colistin and gentamicin was effective and resulted in the cure of this patient's endocarditis without the need for surgical intervention. |
| doi_str_mv | 10.1016/j.ijid.2009.01.006 |
| format | Article |
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An 18-year-old man with 40% full thickness burns developed acute bacterial endocarditis complicated by embolic myocardial infarction. Carbapenem-resistant K. pneumoniae carrying the blaKPC3 gene was isolated from multiple blood cultures. He recovered fully after antibiotic treatment with colistin and gentamicin.
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An 18-year-old man with 40% full thickness burns developed acute bacterial endocarditis complicated by embolic myocardial infarction. Carbapenem-resistant K. pneumoniae carrying the blaKPC3 gene was isolated from multiple blood cultures. He recovered fully after antibiotic treatment with colistin and gentamicin.
To our knowledge, this is the first reported case of acute bacterial endocarditis caused by carbapenem-resistant K. pneumoniae. 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An 18-year-old man with 40% full thickness burns developed acute bacterial endocarditis complicated by embolic myocardial infarction. Carbapenem-resistant K. pneumoniae carrying the blaKPC3 gene was isolated from multiple blood cultures. He recovered fully after antibiotic treatment with colistin and gentamicin.
To our knowledge, this is the first reported case of acute bacterial endocarditis caused by carbapenem-resistant K. pneumoniae. The combination of intravenous colistin and gentamicin was effective and resulted in the cure of this patient's endocarditis without the need for surgical intervention.</abstract><cop>Canada</cop><pmid>19329345</pmid><doi>10.1016/j.ijid.2009.01.006</doi><oa>free_for_read</oa></addata></record> |
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| identifier | EISSN: 1878-3511 |
| ispartof | International journal of infectious diseases, 2009-09, Vol.13 (5), p.e295-e298 |
| issn | 1878-3511 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacterial Proteins - genetics beta-Lactam Resistance - genetics beta-Lactamases - genetics Carbapenems - pharmacology Colistin - therapeutic use Drug Therapy, Combination Endocarditis, Bacterial - drug therapy Endocarditis, Bacterial - microbiology Gentamicins - therapeutic use Humans Klebsiella Infections - drug therapy Klebsiella Infections - microbiology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Male Treatment Outcome |
| title | Carbapenem-resistant Klebsiella pneumoniae endocarditis in a young adult. Successful treatment with gentamicin and colistin |
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