Pharmacological analysis of the neutrophil migration induced by D. rostrata lectin: Involvement of cytokines and nitric oxide

In the present study, we investigated the involvement of resident cell and inflammatory mediators in the neutrophil migration induced by chemotactic activity of a glucose/mannose-specific lectin isolated from Dioclea rostrata seeds (DrosL). Rats were injected i.p. with DrosL (125–1000 μg/cavity), an...

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Veröffentlicht in:	Toxicon (Oxford) 2009-11, Vol.54 (6), p.736-744
Hauptverfasser:	Figueiredo, Jozi G., Bitencourt, Flávio S., Mota, Mário R.L., Silvestre, Priscila P., Aguiar, Cibele N., Benevides, Raquel G., Nascimento, Kyria S., de Moura, Tales R., Dal-Secco, Daniela, Assreuy, Ana M.S., Cunha, Fernando de Q., Vale, Marcus R., Cavada, Benildo S., Alencar, Nylane M.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal poisons toxicology. Antivenoms Animals Biological and medical sciences Cell Movement - drug effects Cytokines Cytokines - physiology Dioclea Dioclea - chemistry Dioclea rostrata Inflammation Lectin Lectins - pharmacology Leukocyte migration Macrophage Male Medical sciences Neutrophils - cytology Neutrophils - drug effects Nitric oxide Nitric Oxide - physiology Plant Extracts - chemistry Rats Rats, Wistar Toxicology
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