Enhanced gene replacements in Ku80 disruption mutants of the dermatophyte, Trichophyton mentagrophytes

The frequency of targeted gene disruption via homologous recombination is low in the clinically important dermatophyte, Trichophyton mentagrophytes. The Ku genes, Ku70 and Ku80, encode key components of the nonhomologous end-joining pathway involved in DNA double-strand break repair. Their deletion...

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Veröffentlicht in:	FEMS microbiology letters 2009-09, Vol.298 (2), p.208-217
Hauptverfasser:	Yamada, Tsuyoshi, Makimura, Koichi, Hisajima, Tatsuya, Ishihara, Yumiko, Umeda, Yoshiko, Abe, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Agrobacterium Agrobacterium tumefaciens - genetics Amino acid sequence Amino acids Biological and medical sciences Deoxyribonucleic acid dermatophytes Disruption DNA DNA damage DNA repair DNA, Fungal - chemistry DNA, Fungal - genetics Double-strand break repair Fundamental and applied biological sciences. Psychology Fungal Proteins - genetics Gene Deletion Gene disruption Genes, Fungal Genetic transformation Genetics Genetics, Microbial - methods Homologous recombination Homology Human mycoses Infectious diseases keratinophilic fungi Ku80 Medical sciences Microbiology Miscellaneous Molecular Sequence Data Mutants Mycology Mycoses Mycoses of the skin nonhomologous end joining Nucleotide sequence Nucleotides Open reading frames Phylogeny Recombination, Genetic Sequence Analysis, DNA Sequence Homology, Amino Acid Serine Serine proteinase targeted gene disruption Trichophyton - genetics Trichophyton mentagrophytes Yeast
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