Echinacea purpurea Significantly Induces Cytochrome P450 3A Activity but Does Not Alter Lopinavir-Ritonavir Exposure in Healthy Subjects

Study Objective. To determine the influence of Echinacea purpurea on the pharmacokinetics of lopinavir‐ritonavir and on cytochrome P450 (CYP)3A and P‐glycoprotein activity by using the probe substrates midazolam and fexofenadine, respectively. Design. Open‐label, single‐sequence pharmacokinetic stud...

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Veröffentlicht in:	Pharmacotherapy 2010-08, Vol.30 (8), p.797-805
Hauptverfasser:	Penzak, Scott R., Robertson, Sarah M., Hunt, Jennifer D., Chairez, Cheryl, Malati, Christine Y., Alfaro, Raul M., Stevenson, James M., Kovacs, Joseph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Confidence intervals CYP Cytochrome Cytochrome P-450 CYP3A - biosynthesis Cytochrome P-450 CYP3A - metabolism cytochrome P450 Drug Combinations drug interaction Drug therapy Echinacea Echinacea purpurea Enzyme Induction - drug effects Enzyme Induction - physiology Female herb Herb-Drug Interactions - physiology HIV Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Lopinavir Male Medical sciences Middle Aged P-glycoprotein P-gp Pharmacology. Drug treatments Plant Extracts - administration & dosage protease inhibitors Pyrimidinones - administration & dosage ritonavir Ritonavir - administration & dosage Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Young Adult
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