Design and Synthesis of 4,6-Di-tert-butyl-2,3-dihydro-5-benzofuranols as a Novel Series of Antiatherogenic Antioxidants

Antioxidants have been considered as potential antiatherogenic agents by inhibiting oxidation of low-density lipoprotein (LDL), albeit vitamin E, a natural antioxidant, has failed to show reduction on atherosclerosis in clinical trials. We have rationally designed and synthesized a novel series of a...

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Veröffentlicht in:	Journal of medicinal chemistry 2003-07, Vol.46 (14), p.3083-3093
Hauptverfasser:	Tamura, Kunio, Kato, Yoshiaki, Ishikawa, Akira, Kato, Yasuharu, Himori, Motomu, Yoshida, Mitsutaka, Takashima, Yoshiaki, Suzuki, Tsukasa, Kawabe, Yoshiki, Cynshi, Osamu, Kodama, Tatsuhiko, Niki, Etsuo, Shimizu, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol - pharmacology Animals Antioxidants - chemical synthesis Antioxidants - pharmacokinetics Antioxidants - pharmacology Arteriosclerosis - prevention & control Benzofurans - chemical synthesis Benzofurans - pharmacokinetics Benzofurans - pharmacology Biological and medical sciences Cardiovascular system Free Radicals General and cellular metabolism. Vitamins Linoleic Acid - chemistry Lipoproteins, LDL - blood Lipoproteins, LDL - chemistry Luminescent Measurements Medical sciences Miscellaneous Oxidation-Reduction Pharmacology. Drug treatments Rabbits Structure-Activity Relationship
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