Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria

Abstract During the course of our screening program to isolate isoprenoids from marine Actinobacteria, 523 actinobacterial strains were isolated from 18 marine sponges, a tunicate, and two marine sediments. These strains belonged to 21 different genera, but most were members of Streptomyces, Nocardi...

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Veröffentlicht in:	FEMS microbiology letters 2010-03, Vol.304 (1), p.89-96
Hauptverfasser:	Khan, Shams Tabrez, Izumikawa, Miho, Motohashi, Keiichiro, Mukai, Akira, Takagi, Motoki, Shin-Ya, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	3‐hydroxy‐3‐methylglutaryl CoA reductases Actinobacteria Actinobacteria - classification Actinobacteria - enzymology Actinobacteria - genetics Actinobacteria - isolation & purification Acute myeloid leukemia Animal, plant and microbial ecology Animals Bacteriology Biological and medical sciences Chromophores Coenzyme A Cytotoxicity Fundamental and applied biological sciences. Psychology Gene clusters Genes Geologic Sediments - microbiology HL-60 Cells - drug effects Humans Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl CoA Reductases - metabolism Hydroxymethylglutaryl-CoA reductase isoprenoid Japan Leukemia marine Actinobacteria Marine Biology Marine sediments marine sponge Metabolism. Enzymes Metabolites Mevalonate pathway Mevalonic acid Microbial ecology Microbiology Micromonospora Molecular Sequence Data Myeloid leukemia Nocardia Phenazine Phylogeny Porifera - microbiology Reductases Rhodococcus Secondary metabolites Sediments Sequence Analysis, DNA Statins Streptomyces Terpenes Terpenes - chemistry Terpenes - metabolism Terpenes - pharmacology Urochordata - microbiology Various environments (extraatmospheric space, air, water)
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