Progeria syndromes and ageing: what is the connection?

Key Points Despite decades of research, the extent to which human progerias resemble accelerated ageing is still unclear and highly debated. To understand this connection, an ongoing characterization of genetic pathways that influence the ageing process in model systems and investigations into molec...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2010-08, Vol.11 (8), p.567-578
Hauptverfasser:	Burtner, Christopher R., Kennedy, Brian K.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/144 631/443/7 631/80/86 692/700/139/422 Aging Aging - genetics Aging - physiology Animals Biochemistry Biological Evolution Biology Biomedical and Life Sciences Cancer Research Cell Biology Complications and side effects Development and progression Developmental Biology DNA Damage DNA Repair Genetic aspects Genotype & phenotype Humans Invertebrates Kinases Lamin Type A - genetics Life Sciences Longevity Longevity - drug effects Longevity - genetics Longevity - physiology Mesenchymal Stromal Cells - pathology Mesenchymal Stromal Cells - physiology Models, Biological Mutation Pathology Physiological aspects Progeria Progeria - etiology Progeria - genetics Progeria - physiopathology Progeria - therapy Proteins review-article Risk factors Signal Transduction Sirolimus - pharmacology Stem Cells Syndrome
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