Does Early Age at Brain Insult Predict Worse Outcome? Neuropsychological Implications
Objective Traditionally early brain insult (EBI) has been argued to have better outcome than later injury, consistent with the notion that the young brain is flexible and able to reorganize. This view was investigated by comparing neurobehavioral outcomes of children sustaining EBI at different deve...
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| Veröffentlicht in: | Journal of pediatric psychology 2010-08, Vol.35 (7), p.716-727 |
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| creator | Anderson, Vicki Jacobs, Rani Spencer-Smith, Megan Coleman, Lee Anderson, Peter Williams, Jackie Greenham, Mardee Leventer, Rick |
| description | Objective Traditionally early brain insult (EBI) has been argued to have better outcome than later injury, consistent with the notion that the young brain is flexible and able to reorganize. This view was investigated by comparing neurobehavioral outcomes of children sustaining EBI at different developmental stages (gestation to late childhood). Methods One hundred and sixty four children who had sustained focal brain insult (confirmed by MRI) formed six groups, based on age at EBI, (a) Congenital; (b) Peri-natal; (c) Infancy; (d) Preschool; (e) Middle Childhood; (f) Late Childhood, and were compared on a range of standardized neurobehavioral measures. Groups were matched for lesion characteristics and demographics. Results Children sustaining EBI before age 2 recorded global deficits, while children with later EBI performed closer to average. Conclusion These results question the advantages of early brain plasticity, demonstrating poorer outcome from very early insults, and increasingly better function with lesions later in childhood. |
| doi_str_mv | 10.1093/jpepsy/jsp100 |
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Neuropsychological Implications</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>EBSCOhost Education Source</source><source>Alma/SFX Local Collection</source><creator>Anderson, Vicki ; Jacobs, Rani ; Spencer-Smith, Megan ; Coleman, Lee ; Anderson, Peter ; Williams, Jackie ; Greenham, Mardee ; Leventer, Rick</creator><creatorcontrib>Anderson, Vicki ; Jacobs, Rani ; Spencer-Smith, Megan ; Coleman, Lee ; Anderson, Peter ; Williams, Jackie ; Greenham, Mardee ; Leventer, Rick</creatorcontrib><description>Objective Traditionally early brain insult (EBI) has been argued to have better outcome than later injury, consistent with the notion that the young brain is flexible and able to reorganize. This view was investigated by comparing neurobehavioral outcomes of children sustaining EBI at different developmental stages (gestation to late childhood). Methods One hundred and sixty four children who had sustained focal brain insult (confirmed by MRI) formed six groups, based on age at EBI, (a) Congenital; (b) Peri-natal; (c) Infancy; (d) Preschool; (e) Middle Childhood; (f) Late Childhood, and were compared on a range of standardized neurobehavioral measures. Groups were matched for lesion characteristics and demographics. Results Children sustaining EBI before age 2 recorded global deficits, while children with later EBI performed closer to average. Conclusion These results question the advantages of early brain plasticity, demonstrating poorer outcome from very early insults, and increasingly better function with lesions later in childhood.</description><identifier>ISSN: 0146-8693</identifier><identifier>EISSN: 1465-735X</identifier><identifier>DOI: 10.1093/jpepsy/jsp100</identifier><identifier>PMID: 19995865</identifier><identifier>CODEN: JPPSDW</identifier><language>eng</language><publisher>Atlanta, GA: Oxford University Press</publisher><subject>Adolescent ; Age Factors ; Analysis of Variance ; Attention ; Biological and medical sciences ; Brain - pathology ; Brain - physiopathology ; Brain Injuries - pathology ; Brain Injuries - physiopathology ; brain injury ; Child ; Child clinical studies ; Executive Function ; Female ; Humans ; Infant ; language ; Language Development ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Memory ; Neuropsychological Tests ; outcome ; plasticity ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>Journal of pediatric psychology, 2010-08, Vol.35 (7), p.716-727</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-7c509e3f15916b72f4522db6b0c91b221a9853b117727466f84a195291b6e36b3</citedby><cites>FETCH-LOGICAL-c399t-7c509e3f15916b72f4522db6b0c91b221a9853b117727466f84a195291b6e36b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23142698$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19995865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anderson, Vicki</creatorcontrib><creatorcontrib>Jacobs, Rani</creatorcontrib><creatorcontrib>Spencer-Smith, Megan</creatorcontrib><creatorcontrib>Coleman, Lee</creatorcontrib><creatorcontrib>Anderson, Peter</creatorcontrib><creatorcontrib>Williams, Jackie</creatorcontrib><creatorcontrib>Greenham, Mardee</creatorcontrib><creatorcontrib>Leventer, Rick</creatorcontrib><title>Does Early Age at Brain Insult Predict Worse Outcome? Neuropsychological Implications</title><title>Journal of pediatric psychology</title><addtitle>J Pediatr Psychol</addtitle><description>Objective Traditionally early brain insult (EBI) has been argued to have better outcome than later injury, consistent with the notion that the young brain is flexible and able to reorganize. This view was investigated by comparing neurobehavioral outcomes of children sustaining EBI at different developmental stages (gestation to late childhood). Methods One hundred and sixty four children who had sustained focal brain insult (confirmed by MRI) formed six groups, based on age at EBI, (a) Congenital; (b) Peri-natal; (c) Infancy; (d) Preschool; (e) Middle Childhood; (f) Late Childhood, and were compared on a range of standardized neurobehavioral measures. Groups were matched for lesion characteristics and demographics. Results Children sustaining EBI before age 2 recorded global deficits, while children with later EBI performed closer to average. Conclusion These results question the advantages of early brain plasticity, demonstrating poorer outcome from very early insults, and increasingly better function with lesions later in childhood.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Analysis of Variance</subject><subject>Attention</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain - physiopathology</subject><subject>Brain Injuries - pathology</subject><subject>Brain Injuries - physiopathology</subject><subject>brain injury</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Executive Function</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>language</subject><subject>Language Development</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Neuropsychological Tests</subject><subject>outcome</subject><subject>plasticity</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><issn>0146-8693</issn><issn>1465-735X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtr3DAQxkVpaTaPY65Fl9KTs3pYknUqyeaxC5vHISEhFyFr5dRb23I1NmT_-yrssi0MzAzfj_mYD6FTSs4o0Xy67n0Pm-kaekrIJzShuRSZ4uLlM5qQtGSF1PwAHQKsCSF5zuVXdEC11qKQYoKeLoMHfGVjs8Hnbx7bAV9EW3d40cHYDPgh-lXtBvwcInh8Pw4utP4nvvNjDMnX_QpNeKudbfCi7Zs0DHXo4Bh9qWwD_mTXj9DT9dXjbJ4t728Ws_Nl5rjWQ6acINrzigpNZalYlQvGVqUsidO0ZIxaXQheUqoUU7mUVZFbqgVLovRclvwI_dje7WP4M3oYTFuD801jOx9GMIrnhBSpEpltSRcDQPSV6WPd2rgxlJiPIM02SLMNMvHfdpfHsvWrf_QuuQR83wEW0vtVtJ2rYc8xTnMm9X_GNQz-fa_b-NtIxZUw85dXc_twezdbXs_NBf8L0J6MPA</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Anderson, Vicki</creator><creator>Jacobs, Rani</creator><creator>Spencer-Smith, Megan</creator><creator>Coleman, Lee</creator><creator>Anderson, Peter</creator><creator>Williams, Jackie</creator><creator>Greenham, Mardee</creator><creator>Leventer, Rick</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>Does Early Age at Brain Insult Predict Worse Outcome? Neuropsychological Implications</title><author>Anderson, Vicki ; Jacobs, Rani ; Spencer-Smith, Megan ; Coleman, Lee ; Anderson, Peter ; Williams, Jackie ; Greenham, Mardee ; Leventer, Rick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-7c509e3f15916b72f4522db6b0c91b221a9853b117727466f84a195291b6e36b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Analysis of Variance</topic><topic>Attention</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain - physiopathology</topic><topic>Brain Injuries - pathology</topic><topic>Brain Injuries - physiopathology</topic><topic>brain injury</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Executive Function</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>language</topic><topic>Language Development</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Neuropsychological Tests</topic><topic>outcome</topic><topic>plasticity</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anderson, Vicki</creatorcontrib><creatorcontrib>Jacobs, Rani</creatorcontrib><creatorcontrib>Spencer-Smith, Megan</creatorcontrib><creatorcontrib>Coleman, Lee</creatorcontrib><creatorcontrib>Anderson, Peter</creatorcontrib><creatorcontrib>Williams, Jackie</creatorcontrib><creatorcontrib>Greenham, Mardee</creatorcontrib><creatorcontrib>Leventer, Rick</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric psychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anderson, Vicki</au><au>Jacobs, Rani</au><au>Spencer-Smith, Megan</au><au>Coleman, Lee</au><au>Anderson, Peter</au><au>Williams, Jackie</au><au>Greenham, Mardee</au><au>Leventer, Rick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does Early Age at Brain Insult Predict Worse Outcome? Neuropsychological Implications</atitle><jtitle>Journal of pediatric psychology</jtitle><addtitle>J Pediatr Psychol</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>35</volume><issue>7</issue><spage>716</spage><epage>727</epage><pages>716-727</pages><issn>0146-8693</issn><eissn>1465-735X</eissn><coden>JPPSDW</coden><abstract>Objective Traditionally early brain insult (EBI) has been argued to have better outcome than later injury, consistent with the notion that the young brain is flexible and able to reorganize. This view was investigated by comparing neurobehavioral outcomes of children sustaining EBI at different developmental stages (gestation to late childhood). Methods One hundred and sixty four children who had sustained focal brain insult (confirmed by MRI) formed six groups, based on age at EBI, (a) Congenital; (b) Peri-natal; (c) Infancy; (d) Preschool; (e) Middle Childhood; (f) Late Childhood, and were compared on a range of standardized neurobehavioral measures. Groups were matched for lesion characteristics and demographics. Results Children sustaining EBI before age 2 recorded global deficits, while children with later EBI performed closer to average. Conclusion These results question the advantages of early brain plasticity, demonstrating poorer outcome from very early insults, and increasingly better function with lesions later in childhood.</abstract><cop>Atlanta, GA</cop><pub>Oxford University Press</pub><pmid>19995865</pmid><doi>10.1093/jpepsy/jsp100</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Age Factors Analysis of Variance Attention Biological and medical sciences Brain - pathology Brain - physiopathology Brain Injuries - pathology Brain Injuries - physiopathology brain injury Child Child clinical studies Executive Function Female Humans Infant language Language Development Magnetic Resonance Imaging Male Medical sciences Memory Neuropsychological Tests outcome plasticity Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Does Early Age at Brain Insult Predict Worse Outcome? Neuropsychological Implications |
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