The consequences of doxorubicin quinone reduction in vivo in tumour tissue

A clear role for quinone reduction in the mechanism of action of doxorubicin has still to be established. There are three possible outcomes of this form of doxorubicin metabolism: (1) drug free radical formation, redox cycling and generation of reactive oxygen species (ROS) resulting in lipid peroxi...

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Veröffentlicht in:	Biochemical pharmacology 1992-12, Vol.44 (11), p.2165-2174
Hauptverfasser:	Cummings, Jeffrey, Willmott, Neville, Hoey, Brigid M., Marley, Elaine S., SMyth, John F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - administration & dosage Animals Antineoplastic agents Biological and medical sciences DNA, Neoplasm - metabolism Doxorubicin - metabolism Doxorubicin - pharmacokinetics Doxorubicin - pharmacology Female General aspects Injections, Intralesional Isotope Labeling Lipid Peroxidation Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - metabolism Medical sciences Microspheres Models, Biological Naphthacenes - metabolism Neoplasm Transplantation Oxidation-Reduction Pharmacology. Drug treatments Phosphorus Radioisotopes Quinones - metabolism Rats Rats, Inbred Strains Tissue Distribution
Online-Zugang:	Volltext
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