Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer
Panax ginseng C. A. Meyer (ginseng) is a well-known Chinese herb often used in Asian countries for physical strength development. Ginseng polysaccharides are its active component and have a lot of pharmaceutical activities. However, anti-fatigue activity of ginseng polysaccharides has not yet been t...
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| Veröffentlicht in: | Journal of ethnopharmacology 2010-07, Vol.130 (2), p.421-423 |
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| creator | Wang, Jia Li, Shanshan Fan, Yuying Chen, Yan Liu, Dan Cheng, Hairong Gao, Xiaoge Zhou, Yifa |
| description | Panax ginseng C. A. Meyer (ginseng) is a well-known Chinese herb often used in Asian countries for physical strength development. Ginseng polysaccharides are its active component and have a lot of pharmaceutical activities. However, anti-fatigue activity of ginseng polysaccharides has not yet been tested. The current study was designed to evaluate the anti-fatigue activity of ginseng polysaccharides (WGP) in an animal test for fatigue and compare the activities between the neutral (WGPN) and acidic (WGPA) portion in an attempt to determine whether the medicinal uses are supported by pharmacological effects.
WGP, WGPN and WGPA were orally administrated to mice once daily for 15 days. Anti-fatigue activity was assessed using the forced swim test (FST) and serum biochemical parameters were determined by autoanalyzer and commercially available kits.
While all compounds were found to reduce immobility in the FST, the effect of WGPA was demonstrated in lower doses compared with WGP and WGPN. Moreover, the FST-induced reduction in glucose (GLU) and glutathione peroxidase (GPx) and increase in creatine phosphokinase (CK), lactic dehydrogenase (LDH) and malondialdehyde (MDA) levels, all indicators of fatigue, were inhibited by the corresponding doses of WGP, WGPN and WGPA.
Ginseng polysaccharides have anti-fatigue activity, also reflected in the effects on the physiological markers for fatigue. The acidic polysaccharide is more potent than the neutral polysaccharide. |
| doi_str_mv | 10.1016/j.jep.2010.05.027 |
| format | Article |
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WGP, WGPN and WGPA were orally administrated to mice once daily for 15 days. Anti-fatigue activity was assessed using the forced swim test (FST) and serum biochemical parameters were determined by autoanalyzer and commercially available kits.
While all compounds were found to reduce immobility in the FST, the effect of WGPA was demonstrated in lower doses compared with WGP and WGPN. Moreover, the FST-induced reduction in glucose (GLU) and glutathione peroxidase (GPx) and increase in creatine phosphokinase (CK), lactic dehydrogenase (LDH) and malondialdehyde (MDA) levels, all indicators of fatigue, were inhibited by the corresponding doses of WGP, WGPN and WGPA.
Ginseng polysaccharides have anti-fatigue activity, also reflected in the effects on the physiological markers for fatigue. The acidic polysaccharide is more potent than the neutral polysaccharide.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2010.05.027</identifier><identifier>PMID: 20580802</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>acidity ; Administration, Oral ; animal models ; Animals ; Anti-fatigue activity ; aqueous solutions ; Behavior, Animal - drug effects ; Biological and medical sciences ; biomarkers ; Biomarkers - blood ; Blood Glucose - metabolism ; Creatine Kinase - blood ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Fatigue - metabolism ; Fatigue - prevention & control ; Fatigue - psychology ; Forced swim test ; General pharmacology ; Ginseng ; Glutathione Peroxidase - blood ; L-Lactate Dehydrogenase - blood ; Male ; Malondialdehyde - blood ; Medical sciences ; medicinal plants ; medicinal properties ; Mice ; Mice, Inbred ICR ; muscle fatigue ; oral administration ; Panax ; Panax ginseng ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - administration & dosage ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Roots ; Polysaccharides ; Polysaccharides - administration & dosage ; Polysaccharides - chemistry ; Polysaccharides - isolation & purification ; Polysaccharides - pharmacology ; Solubility ; Solvents - chemistry ; Swimming ; Water - chemistry</subject><ispartof>Journal of ethnopharmacology, 2010-07, Vol.130 (2), p.421-423</ispartof><rights>2010 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-95d33f46a5f9e3fa03837cd3ae5b8bc42257a047f83c9106d992deed58e4e1af3</citedby><cites>FETCH-LOGICAL-c472t-95d33f46a5f9e3fa03837cd3ae5b8bc42257a047f83c9106d992deed58e4e1af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2010.05.027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23049949$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20580802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jia</creatorcontrib><creatorcontrib>Li, Shanshan</creatorcontrib><creatorcontrib>Fan, Yuying</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Liu, Dan</creatorcontrib><creatorcontrib>Cheng, Hairong</creatorcontrib><creatorcontrib>Gao, Xiaoge</creatorcontrib><creatorcontrib>Zhou, Yifa</creatorcontrib><title>Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Panax ginseng C. A. Meyer (ginseng) is a well-known Chinese herb often used in Asian countries for physical strength development. Ginseng polysaccharides are its active component and have a lot of pharmaceutical activities. However, anti-fatigue activity of ginseng polysaccharides has not yet been tested. The current study was designed to evaluate the anti-fatigue activity of ginseng polysaccharides (WGP) in an animal test for fatigue and compare the activities between the neutral (WGPN) and acidic (WGPA) portion in an attempt to determine whether the medicinal uses are supported by pharmacological effects.
WGP, WGPN and WGPA were orally administrated to mice once daily for 15 days. Anti-fatigue activity was assessed using the forced swim test (FST) and serum biochemical parameters were determined by autoanalyzer and commercially available kits.
While all compounds were found to reduce immobility in the FST, the effect of WGPA was demonstrated in lower doses compared with WGP and WGPN. Moreover, the FST-induced reduction in glucose (GLU) and glutathione peroxidase (GPx) and increase in creatine phosphokinase (CK), lactic dehydrogenase (LDH) and malondialdehyde (MDA) levels, all indicators of fatigue, were inhibited by the corresponding doses of WGP, WGPN and WGPA.
Ginseng polysaccharides have anti-fatigue activity, also reflected in the effects on the physiological markers for fatigue. The acidic polysaccharide is more potent than the neutral polysaccharide.</description><subject>acidity</subject><subject>Administration, Oral</subject><subject>animal models</subject><subject>Animals</subject><subject>Anti-fatigue activity</subject><subject>aqueous solutions</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Creatine Kinase - blood</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fatigue - metabolism</subject><subject>Fatigue - prevention & control</subject><subject>Fatigue - psychology</subject><subject>Forced swim test</subject><subject>General pharmacology</subject><subject>Ginseng</subject><subject>Glutathione Peroxidase - blood</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>muscle fatigue</subject><subject>oral administration</subject><subject>Panax</subject><subject>Panax ginseng</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots</subject><subject>Polysaccharides</subject><subject>Polysaccharides - administration & dosage</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - isolation & purification</subject><subject>Polysaccharides - pharmacology</subject><subject>Solubility</subject><subject>Solvents - chemistry</subject><subject>Swimming</subject><subject>Water - chemistry</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuP0zAQgC0EYsvCD-ACviBOCePYrmNxqipe0iKQYM_W1Bl3XaVJsZOF_ntctcCN02g03zz0DWPPBdQCxPLNrt7RoW6g5KBraMwDthCtaSqjjXzIFiBNW7VGiSv2JOcdABih4DG7akC30EKzYJvVMMUq4BS3M3H0U7yP05GPgU93xH_iRKnKYz9veuKHsT9m9P4OU-wo81gKBeh4SOOef8UBf_FtHDINW76u-armn-lI6Sl7FLDP9OwSr9nt-3ff1x-rmy8fPq1XN5VXppkqqzspg1qiDpZkQJCtNL6TSHrTbrxqGm0QlAmt9FbAsrO26Yg63ZIigUFes9fnuYc0_pgpT24fs6e-x4HGOTsjFYC2FgopzqRPY86JgjukuMd0dALcyazbuWLWncw60K6YLT0vLtPnzZ66vx1_VBbg1QXA7LEPCQcf8z9OgrJW2cK9PHMBR4fbVJjbb2WThPI6AHFa9fZMULF1Hym57CMNnrqYyE-uG-N_Dv0NiUmfYQ</recordid><startdate>20100720</startdate><enddate>20100720</enddate><creator>Wang, Jia</creator><creator>Li, Shanshan</creator><creator>Fan, Yuying</creator><creator>Chen, Yan</creator><creator>Liu, Dan</creator><creator>Cheng, Hairong</creator><creator>Gao, Xiaoge</creator><creator>Zhou, Yifa</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100720</creationdate><title>Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer</title><author>Wang, Jia ; Li, Shanshan ; Fan, Yuying ; Chen, Yan ; Liu, Dan ; Cheng, Hairong ; Gao, Xiaoge ; Zhou, Yifa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-95d33f46a5f9e3fa03837cd3ae5b8bc42257a047f83c9106d992deed58e4e1af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>acidity</topic><topic>Administration, Oral</topic><topic>animal models</topic><topic>Animals</topic><topic>Anti-fatigue activity</topic><topic>aqueous solutions</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Creatine Kinase - blood</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fatigue - metabolism</topic><topic>Fatigue - prevention & control</topic><topic>Fatigue - psychology</topic><topic>Forced swim test</topic><topic>General pharmacology</topic><topic>Ginseng</topic><topic>Glutathione Peroxidase - blood</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>muscle fatigue</topic><topic>oral administration</topic><topic>Panax</topic><topic>Panax ginseng</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots</topic><topic>Polysaccharides</topic><topic>Polysaccharides - administration & dosage</topic><topic>Polysaccharides - chemistry</topic><topic>Polysaccharides - isolation & purification</topic><topic>Polysaccharides - pharmacology</topic><topic>Solubility</topic><topic>Solvents - chemistry</topic><topic>Swimming</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jia</creatorcontrib><creatorcontrib>Li, Shanshan</creatorcontrib><creatorcontrib>Fan, Yuying</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Liu, Dan</creatorcontrib><creatorcontrib>Cheng, Hairong</creatorcontrib><creatorcontrib>Gao, Xiaoge</creatorcontrib><creatorcontrib>Zhou, Yifa</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jia</au><au>Li, Shanshan</au><au>Fan, Yuying</au><au>Chen, Yan</au><au>Liu, Dan</au><au>Cheng, Hairong</au><au>Gao, Xiaoge</au><au>Zhou, Yifa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2010-07-20</date><risdate>2010</risdate><volume>130</volume><issue>2</issue><spage>421</spage><epage>423</epage><pages>421-423</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Panax ginseng C. A. Meyer (ginseng) is a well-known Chinese herb often used in Asian countries for physical strength development. Ginseng polysaccharides are its active component and have a lot of pharmaceutical activities. However, anti-fatigue activity of ginseng polysaccharides has not yet been tested. The current study was designed to evaluate the anti-fatigue activity of ginseng polysaccharides (WGP) in an animal test for fatigue and compare the activities between the neutral (WGPN) and acidic (WGPA) portion in an attempt to determine whether the medicinal uses are supported by pharmacological effects.
WGP, WGPN and WGPA were orally administrated to mice once daily for 15 days. Anti-fatigue activity was assessed using the forced swim test (FST) and serum biochemical parameters were determined by autoanalyzer and commercially available kits.
While all compounds were found to reduce immobility in the FST, the effect of WGPA was demonstrated in lower doses compared with WGP and WGPN. Moreover, the FST-induced reduction in glucose (GLU) and glutathione peroxidase (GPx) and increase in creatine phosphokinase (CK), lactic dehydrogenase (LDH) and malondialdehyde (MDA) levels, all indicators of fatigue, were inhibited by the corresponding doses of WGP, WGPN and WGPA.
Ginseng polysaccharides have anti-fatigue activity, also reflected in the effects on the physiological markers for fatigue. The acidic polysaccharide is more potent than the neutral polysaccharide.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>20580802</pmid><doi>10.1016/j.jep.2010.05.027</doi><tpages>3</tpages></addata></record> |
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| subjects | acidity Administration, Oral animal models Animals Anti-fatigue activity aqueous solutions Behavior, Animal - drug effects Biological and medical sciences biomarkers Biomarkers - blood Blood Glucose - metabolism Creatine Kinase - blood Disease Models, Animal Dose-Response Relationship, Drug Fatigue - metabolism Fatigue - prevention & control Fatigue - psychology Forced swim test General pharmacology Ginseng Glutathione Peroxidase - blood L-Lactate Dehydrogenase - blood Male Malondialdehyde - blood Medical sciences medicinal plants medicinal properties Mice Mice, Inbred ICR muscle fatigue oral administration Panax Panax ginseng Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots Polysaccharides Polysaccharides - administration & dosage Polysaccharides - chemistry Polysaccharides - isolation & purification Polysaccharides - pharmacology Solubility Solvents - chemistry Swimming Water - chemistry |
| title | Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng C. A. Meyer |
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