The inositol phosphatase SHIP-1 is negatively regulated by Fli-1 and its loss accelerates leukemogenesis

The activation of Fli-1, an Ets transcription factor, is the critical genetic event in Friend murine leukemia virus (F-MuLV)–induced erythroleukemia. Fli-1 overexpression leads to erythropoietin-dependent erythroblast proliferation, enhanced survival, and inhibition of terminal differentiation, thro...

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Veröffentlicht in:	Blood 2010-07, Vol.116 (3), p.428-436
Hauptverfasser:	Lakhanpal, Gurpreet K., Vecchiarelli-Federico, Laura M., Li, You-Jun, Cui, Jiu-Wei, Bailey, Monica L., Spaner, David E., Dumont, Daniel J., Barber, Dwayne L., Ben-David, Yaacov
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Binding Sites - genetics Biological and medical sciences Cell Line DNA - genetics DNA - metabolism DNA Primers - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Feedback, Physiological Friend murine leukemia virus - pathogenicity Hematologic and hematopoietic diseases Humans Inositol Polyphosphate 5-Phosphatases Leukemia, Erythroblastic, Acute - etiology Leukemia, Erythroblastic, Acute - genetics Leukemia, Erythroblastic, Acute - virology Medical sciences Mice Mice, Inbred BALB C Mice, Knockout Models, Biological Molecular Sequence Data Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Phosphoric Monoester Hydrolases - antagonists & inhibitors Phosphoric Monoester Hydrolases - deficiency Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Phosphorylation Promoter Regions, Genetic Proto-Oncogene Protein c-fli-1 - genetics Proto-Oncogene Protein c-fli-1 - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA, Small Interfering - genetics
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