A Systematic Review of the Factors Affecting Accuracy of SUV Measurements

There is growing interest in using PET/CT for evaluating early response to therapy in cancer treatment. Although widely available and convenient to use, standardized uptake value (SUV) measurements can be influenced by a variety of biologic and technologic factors. Many of these factors can be addre...

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Veröffentlicht in:American journal of roentgenology (1976) 2010-08, Vol.195 (2), p.310-320
Hauptverfasser: ADAMS, Michael C, TURKINGTON, Timothy G, WILSON, Joshua M, WONG, Terence Z
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container_issue 2
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container_title American journal of roentgenology (1976)
container_volume 195
creator ADAMS, Michael C
TURKINGTON, Timothy G
WILSON, Joshua M
WONG, Terence Z
description There is growing interest in using PET/CT for evaluating early response to therapy in cancer treatment. Although widely available and convenient to use, standardized uptake value (SUV) measurements can be influenced by a variety of biologic and technologic factors. Many of these factors can be addressed with close attention to detail and appropriate quality control. This article will review factors potentially affecting SUV measurements and provide recommendations on ways to minimize when using serial PET to assess early response to therapy. Scanner and reconstruction parameters can significantly affect SUV measurements. When using serial SUV measurements to assess early response to therapy, imaging should be performed on the same scanner using the same image acquisition and reconstruction protocols. In addition, attention to detail is required for accurate determination of the administered radiopharmaceutical dose.
doi_str_mv 10.2214/ajr.10.4923
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source American Roentgen Ray Society; MEDLINE; Alma/SFX Local Collection
subjects Algorithms
Biological and medical sciences
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Models, Biological
Neoplasms - diagnostic imaging
Neoplasms - metabolism
Positron-Emission Tomography - methods
Radiopharmaceuticals - pharmacokinetics
Reproducibility of Results
Sensitivity and Specificity
title A Systematic Review of the Factors Affecting Accuracy of SUV Measurements
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