Anti–Bullous Pemphigoid 180 and 230 Antibodies in a Sample of Unaffected Subjects
OBJECTIVE To evaluate the prevalence of autoantibodies against 2 hemidesmosomal proteins typically found in patients with bullous pemphigoid (BP), BP antigen II (BP180) and BP antigen I (BP230), in persons without BP. DESIGN Cross-sectional study. SETTING Academic medical center. PATIENTS An age- an...
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| Veröffentlicht in: | Archives of dermatology (1960) 2010-01, Vol.146 (1), p.21-25 |
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| creator | Wieland, Carilyn N Comfere, Nneka I Gibson, Lawrence E Weaver, Amy L Krause, Patricia K Murray, Joseph A |
| description | OBJECTIVE To evaluate the prevalence of autoantibodies against 2 hemidesmosomal proteins typically found in patients with bullous pemphigoid (BP), BP antigen II (BP180) and BP antigen I (BP230), in persons without BP. DESIGN Cross-sectional study. SETTING Academic medical center. PATIENTS An age- and sex-stratified, random, population-based sample of local county patients seen during 2007: 20 men and 20 women per decade of age (from age 20 to 89 years) and 57 patients (33 women and 24 men) aged 90 to 99 years. INTERVENTION Stored serum samples were retrieved for analysis by enzyme-linked immunosorbent assay and indirect immunofluorescence. MAIN OUTCOME MEASURE Presence of circulating autoantibodies to BP180 and BP230. RESULTS Of the 337 study patients, 25 (7.4%) were positive for 1 or both autoantibodies; these 25 samples all tested negative with indirect immunofluorescence. Autoantibody levels did not vary by age or sex. CONCLUSIONS Bullous pemphigoid has a higher incidence in the elderly population, but the prevalence of antibodies to BP180 and BP230 did not increase significantly with age or vary by sex in this population-based sample. Other exogenous factors may affect the development of these autoantibodies in a population without clinically evident immunobullous disease, including limitations inherent to the test (false-positive rate).Arch Dermatol. 2010; 146(1):21-25
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| doi_str_mv | 10.1001/archdermatol.2009.331 |
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--></description><identifier>ISSN: 0003-987X</identifier><identifier>ISSN: 2168-6068</identifier><identifier>EISSN: 1538-3652</identifier><identifier>EISSN: 2168-6084</identifier><identifier>DOI: 10.1001/archdermatol.2009.331</identifier><identifier>PMID: 20083688</identifier><identifier>CODEN: ARDEAC</identifier><language>eng</language><publisher>Chicago, IL: American Medical Association</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Autoantibodies - blood ; Autoantigens - blood ; Autoantigens - immunology ; Biological and medical sciences ; Bullous diseases of the skin ; Collagen Type XVII ; Cross-Sectional Studies ; Dermatology ; Enzyme-Linked Immunosorbent Assay ; Female ; Fluorescent Antibody Technique, Indirect ; Humans ; Male ; Medical sciences ; Middle Aged ; Non-Fibrillar Collagens - blood ; Non-Fibrillar Collagens - immunology ; Pemphigoid, Bullous - blood ; Pemphigoid, Bullous - immunology ; Prognosis ; Proteins ; Skin diseases ; Studies ; Young Adult</subject><ispartof>Archives of dermatology (1960), 2010-01, Vol.146 (1), p.21-25</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Medical Association Jan 2010</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a449t-1c7cb26052cd78a539a9a711dfb53e27e529dd038c707464ed1fb8b1323e53043</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamadermatology/articlepdf/10.1001/archdermatol.2009.331$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamadermatology/fullarticle/10.1001/archdermatol.2009.331$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,776,780,3327,4010,27900,27901,27902,76458,76461</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22333587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20083688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wieland, Carilyn N</creatorcontrib><creatorcontrib>Comfere, Nneka I</creatorcontrib><creatorcontrib>Gibson, Lawrence E</creatorcontrib><creatorcontrib>Weaver, Amy L</creatorcontrib><creatorcontrib>Krause, Patricia K</creatorcontrib><creatorcontrib>Murray, Joseph A</creatorcontrib><title>Anti–Bullous Pemphigoid 180 and 230 Antibodies in a Sample of Unaffected Subjects</title><title>Archives of dermatology (1960)</title><addtitle>Arch Dermatol</addtitle><description>OBJECTIVE To evaluate the prevalence of autoantibodies against 2 hemidesmosomal proteins typically found in patients with bullous pemphigoid (BP), BP antigen II (BP180) and BP antigen I (BP230), in persons without BP. DESIGN Cross-sectional study. SETTING Academic medical center. PATIENTS An age- and sex-stratified, random, population-based sample of local county patients seen during 2007: 20 men and 20 women per decade of age (from age 20 to 89 years) and 57 patients (33 women and 24 men) aged 90 to 99 years. INTERVENTION Stored serum samples were retrieved for analysis by enzyme-linked immunosorbent assay and indirect immunofluorescence. MAIN OUTCOME MEASURE Presence of circulating autoantibodies to BP180 and BP230. RESULTS Of the 337 study patients, 25 (7.4%) were positive for 1 or both autoantibodies; these 25 samples all tested negative with indirect immunofluorescence. Autoantibody levels did not vary by age or sex. CONCLUSIONS Bullous pemphigoid has a higher incidence in the elderly population, but the prevalence of antibodies to BP180 and BP230 did not increase significantly with age or vary by sex in this population-based sample. Other exogenous factors may affect the development of these autoantibodies in a population without clinically evident immunobullous disease, including limitations inherent to the test (false-positive rate).Arch Dermatol. 2010; 146(1):21-25
--></description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autoantibodies - blood</subject><subject>Autoantigens - blood</subject><subject>Autoantigens - immunology</subject><subject>Biological and medical sciences</subject><subject>Bullous diseases of the skin</subject><subject>Collagen Type XVII</subject><subject>Cross-Sectional Studies</subject><subject>Dermatology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fluorescent Antibody Technique, Indirect</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non-Fibrillar Collagens - blood</subject><subject>Non-Fibrillar Collagens - immunology</subject><subject>Pemphigoid, Bullous - blood</subject><subject>Pemphigoid, Bullous - immunology</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Skin diseases</subject><subject>Studies</subject><subject>Young Adult</subject><issn>0003-987X</issn><issn>2168-6068</issn><issn>1538-3652</issn><issn>2168-6084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0N1qFDEUB_BQlHatPkAvlFAQr2Z7kjPZZC7b4hcULKwF78KZJGNnmY81mbnwru_gG_okZtltFa8SyO9_OPkz9lrAUgCIC4ru3ofY0zR2SwlQLRHFEVsIhabAlZLP2AIAsKiM_nbCXqS0yTFpjDxmJ9kbXBmzYOvLYWp_P_y6mrtunBO_Df32vv0-tp4LA5wGzyUC36l69G1IvB048TX12y7wseF3AzVNcFPwfD3Xm3xLL9nzhroUXh3OU3b34f3X60_FzZePn68vbwoqy2oqhNOulitQ0nltSGFFFWkhfFMrDFIHJSvvAY3ToMtVGbxoalMLlBgUQomn7N1-7jaOP-aQJtu3yYWuoyHkv1iNJWSGKsvz_-RmnOOQl7My1yZASshI7ZGLY0oxNHYb257iTyvA7jq3_3Zud53bHM65N4fhc90H_5R6LDmDtwdAyVHXRBpcm_66vAIqo7M72zvq6em1lFCVgH8A5ceTxg</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Wieland, Carilyn N</creator><creator>Comfere, Nneka I</creator><creator>Gibson, Lawrence E</creator><creator>Weaver, Amy L</creator><creator>Krause, Patricia K</creator><creator>Murray, Joseph A</creator><general>American Medical Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Anti–Bullous Pemphigoid 180 and 230 Antibodies in a Sample of Unaffected Subjects</title><author>Wieland, Carilyn N ; Comfere, Nneka I ; Gibson, Lawrence E ; Weaver, Amy L ; Krause, Patricia K ; Murray, Joseph A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a449t-1c7cb26052cd78a539a9a711dfb53e27e529dd038c707464ed1fb8b1323e53043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autoantibodies - blood</topic><topic>Autoantigens - blood</topic><topic>Autoantigens - immunology</topic><topic>Biological and medical sciences</topic><topic>Bullous diseases of the skin</topic><topic>Collagen Type XVII</topic><topic>Cross-Sectional Studies</topic><topic>Dermatology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fluorescent Antibody Technique, Indirect</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non-Fibrillar Collagens - blood</topic><topic>Non-Fibrillar Collagens - immunology</topic><topic>Pemphigoid, Bullous - blood</topic><topic>Pemphigoid, Bullous - immunology</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Skin diseases</topic><topic>Studies</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Wieland, Carilyn N</creatorcontrib><creatorcontrib>Comfere, Nneka I</creatorcontrib><creatorcontrib>Gibson, Lawrence E</creatorcontrib><creatorcontrib>Weaver, Amy L</creatorcontrib><creatorcontrib>Krause, Patricia K</creatorcontrib><creatorcontrib>Murray, Joseph A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of dermatology (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wieland, Carilyn N</au><au>Comfere, Nneka I</au><au>Gibson, Lawrence E</au><au>Weaver, Amy L</au><au>Krause, Patricia K</au><au>Murray, Joseph A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti–Bullous Pemphigoid 180 and 230 Antibodies in a Sample of Unaffected Subjects</atitle><jtitle>Archives of dermatology (1960)</jtitle><addtitle>Arch Dermatol</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>146</volume><issue>1</issue><spage>21</spage><epage>25</epage><pages>21-25</pages><issn>0003-987X</issn><issn>2168-6068</issn><eissn>1538-3652</eissn><eissn>2168-6084</eissn><coden>ARDEAC</coden><abstract>OBJECTIVE To evaluate the prevalence of autoantibodies against 2 hemidesmosomal proteins typically found in patients with bullous pemphigoid (BP), BP antigen II (BP180) and BP antigen I (BP230), in persons without BP. DESIGN Cross-sectional study. SETTING Academic medical center. PATIENTS An age- and sex-stratified, random, population-based sample of local county patients seen during 2007: 20 men and 20 women per decade of age (from age 20 to 89 years) and 57 patients (33 women and 24 men) aged 90 to 99 years. INTERVENTION Stored serum samples were retrieved for analysis by enzyme-linked immunosorbent assay and indirect immunofluorescence. MAIN OUTCOME MEASURE Presence of circulating autoantibodies to BP180 and BP230. RESULTS Of the 337 study patients, 25 (7.4%) were positive for 1 or both autoantibodies; these 25 samples all tested negative with indirect immunofluorescence. Autoantibody levels did not vary by age or sex. CONCLUSIONS Bullous pemphigoid has a higher incidence in the elderly population, but the prevalence of antibodies to BP180 and BP230 did not increase significantly with age or vary by sex in this population-based sample. Other exogenous factors may affect the development of these autoantibodies in a population without clinically evident immunobullous disease, including limitations inherent to the test (false-positive rate).Arch Dermatol. 2010; 146(1):21-25
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| subjects | Adult Aged Aged, 80 and over Autoantibodies - blood Autoantigens - blood Autoantigens - immunology Biological and medical sciences Bullous diseases of the skin Collagen Type XVII Cross-Sectional Studies Dermatology Enzyme-Linked Immunosorbent Assay Female Fluorescent Antibody Technique, Indirect Humans Male Medical sciences Middle Aged Non-Fibrillar Collagens - blood Non-Fibrillar Collagens - immunology Pemphigoid, Bullous - blood Pemphigoid, Bullous - immunology Prognosis Proteins Skin diseases Studies Young Adult |
| title | Anti–Bullous Pemphigoid 180 and 230 Antibodies in a Sample of Unaffected Subjects |
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