p53 and p27 gene expression in subserosal gallbladder carcinoma
Subserosal carcinoma is the stage that presents the greatest difficulty in the diagnosis therapeutic handling and prognosis evaluation. To study the expression of p53 and p27 genes in subserosal gallbladder cancer. One hundred twenty seven tissue samples of subserosal gallbladder cancer (coming from...
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| Veröffentlicht in: | Revista medíca de Chile 2009-08, Vol.137 (8), p.1017-1022 |
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| creator | Roa E, Iván Lantadilla H, Soledad Ibacache S, Gilda de Aretxabala U, Xabier |
| description | Subserosal carcinoma is the stage that presents the greatest difficulty in the diagnosis therapeutic handling and prognosis evaluation.
To study the expression of p53 and p27 genes in subserosal gallbladder cancer.
One hundred twenty seven tissue samples of subserosal gallbladder cancer (coming from 112 females aged 62+/-13 years and 15 men aged 67+/-17 years) and 50 control samples were selected to construct tissue arrays. p53 and p27 genes were determined by immunohistochemistry.
Thirty eight percent of tumors were not detected at the macroscopic examination, 52% and 17% had lymph node and blood vessel involvement, respectively. Fifty six and 46% were positive for p53 and p27, respectively. No association between the expression of both genes and gender, degree of differentiation, lymph node or blood vessel involvement, was observed. Overall five years actuarial survival was 32%. Patients with positive or negative p53 expression had a 22% and 53% survival, respectively (p=0.05). No association between survival and p27 expression was observed.
p53 gene expression is a prognostic factor for subserosal gallbladder cancer. |
| format | Article |
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To study the expression of p53 and p27 genes in subserosal gallbladder cancer.
One hundred twenty seven tissue samples of subserosal gallbladder cancer (coming from 112 females aged 62+/-13 years and 15 men aged 67+/-17 years) and 50 control samples were selected to construct tissue arrays. p53 and p27 genes were determined by immunohistochemistry.
Thirty eight percent of tumors were not detected at the macroscopic examination, 52% and 17% had lymph node and blood vessel involvement, respectively. Fifty six and 46% were positive for p53 and p27, respectively. No association between the expression of both genes and gender, degree of differentiation, lymph node or blood vessel involvement, was observed. Overall five years actuarial survival was 32%. Patients with positive or negative p53 expression had a 22% and 53% survival, respectively (p=0.05). No association between survival and p27 expression was observed.
p53 gene expression is a prognostic factor for subserosal gallbladder cancer.</description><identifier>ISSN: 0034-9887</identifier><identifier>PMID: 19915764</identifier><language>spa</language><publisher>Chile</publisher><subject>Aged ; Biomarkers, Tumor - genetics ; Blood vessels ; Carcinoma ; Carcinoma - genetics ; Carcinoma - mortality ; Carcinoma - pathology ; Cyclin-Dependent Kinase Inhibitor p27 - genetics ; Differentiation ; Female ; Gallbladder ; Gallbladder Neoplasms - genetics ; Gallbladder Neoplasms - mortality ; Gallbladder Neoplasms - pathology ; Humans ; Immunohistochemistry ; Lymph nodes ; Male ; Middle Aged ; p27 gene ; p53 protein ; Prognosis ; Serous Membrane - pathology ; Survival ; Tumor Suppressor Protein p53 - genetics ; Tumors</subject><ispartof>Revista medíca de Chile, 2009-08, Vol.137 (8), p.1017-1022</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19915764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roa E, Iván</creatorcontrib><creatorcontrib>Lantadilla H, Soledad</creatorcontrib><creatorcontrib>Ibacache S, Gilda</creatorcontrib><creatorcontrib>de Aretxabala U, Xabier</creatorcontrib><title>p53 and p27 gene expression in subserosal gallbladder carcinoma</title><title>Revista medíca de Chile</title><addtitle>Rev Med Chil</addtitle><description>Subserosal carcinoma is the stage that presents the greatest difficulty in the diagnosis therapeutic handling and prognosis evaluation.
To study the expression of p53 and p27 genes in subserosal gallbladder cancer.
One hundred twenty seven tissue samples of subserosal gallbladder cancer (coming from 112 females aged 62+/-13 years and 15 men aged 67+/-17 years) and 50 control samples were selected to construct tissue arrays. p53 and p27 genes were determined by immunohistochemistry.
Thirty eight percent of tumors were not detected at the macroscopic examination, 52% and 17% had lymph node and blood vessel involvement, respectively. Fifty six and 46% were positive for p53 and p27, respectively. No association between the expression of both genes and gender, degree of differentiation, lymph node or blood vessel involvement, was observed. Overall five years actuarial survival was 32%. Patients with positive or negative p53 expression had a 22% and 53% survival, respectively (p=0.05). No association between survival and p27 expression was observed.
p53 gene expression is a prognostic factor for subserosal gallbladder cancer.</description><subject>Aged</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Blood vessels</subject><subject>Carcinoma</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - pathology</subject><subject>Cyclin-Dependent Kinase Inhibitor p27 - genetics</subject><subject>Differentiation</subject><subject>Female</subject><subject>Gallbladder</subject><subject>Gallbladder Neoplasms - genetics</subject><subject>Gallbladder Neoplasms - mortality</subject><subject>Gallbladder Neoplasms - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymph nodes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>p27 gene</subject><subject>p53 protein</subject><subject>Prognosis</subject><subject>Serous Membrane - pathology</subject><subject>Survival</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Tumors</subject><issn>0034-9887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhrNQnHH0FSQrXRVycm1XIoM6woAbXZc0OR0qaRqTKejbW3Dcuvo3H__tjKwZE7Jq6tqsyGUpH4xxo6G-ICtoGlBGyzW5T0pQGz1N3NADRqT4lTKWMkyRDpGWuSuYp2IDPdgQumC9x0ydzW6I02ivyHlvQ8Hrk27I-9Pj23ZX7V-fX7YP-yqBgWPllVFggdWotbDegeLMLhU4R9drDkYY6JUWCOgb12kBktcMtAZTO86l2JC7X9-Up88Zy7Edh-IwBBtxmktrhFzmLQ4LefsvyYEv6ZIv4M0JnLsRfZvyMNr83f6dI34ATVRcqA</recordid><startdate>200908</startdate><enddate>200908</enddate><creator>Roa E, Iván</creator><creator>Lantadilla H, Soledad</creator><creator>Ibacache S, Gilda</creator><creator>de Aretxabala U, Xabier</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200908</creationdate><title>p53 and p27 gene expression in subserosal gallbladder carcinoma</title><author>Roa E, Iván ; Lantadilla H, Soledad ; Ibacache S, Gilda ; de Aretxabala U, Xabier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p171t-d5751a108e663adc1520a15722ecf6217371f563e1ed9cb6314280166178c2243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Blood vessels</topic><topic>Carcinoma</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - pathology</topic><topic>Cyclin-Dependent Kinase Inhibitor p27 - genetics</topic><topic>Differentiation</topic><topic>Female</topic><topic>Gallbladder</topic><topic>Gallbladder Neoplasms - genetics</topic><topic>Gallbladder Neoplasms - mortality</topic><topic>Gallbladder Neoplasms - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymph nodes</topic><topic>Male</topic><topic>Middle Aged</topic><topic>p27 gene</topic><topic>p53 protein</topic><topic>Prognosis</topic><topic>Serous Membrane - pathology</topic><topic>Survival</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roa E, Iván</creatorcontrib><creatorcontrib>Lantadilla H, Soledad</creatorcontrib><creatorcontrib>Ibacache S, Gilda</creatorcontrib><creatorcontrib>de Aretxabala U, Xabier</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Revista medíca de Chile</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roa E, Iván</au><au>Lantadilla H, Soledad</au><au>Ibacache S, Gilda</au><au>de Aretxabala U, Xabier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>p53 and p27 gene expression in subserosal gallbladder carcinoma</atitle><jtitle>Revista medíca de Chile</jtitle><addtitle>Rev Med Chil</addtitle><date>2009-08</date><risdate>2009</risdate><volume>137</volume><issue>8</issue><spage>1017</spage><epage>1022</epage><pages>1017-1022</pages><issn>0034-9887</issn><abstract>Subserosal carcinoma is the stage that presents the greatest difficulty in the diagnosis therapeutic handling and prognosis evaluation.
To study the expression of p53 and p27 genes in subserosal gallbladder cancer.
One hundred twenty seven tissue samples of subserosal gallbladder cancer (coming from 112 females aged 62+/-13 years and 15 men aged 67+/-17 years) and 50 control samples were selected to construct tissue arrays. p53 and p27 genes were determined by immunohistochemistry.
Thirty eight percent of tumors were not detected at the macroscopic examination, 52% and 17% had lymph node and blood vessel involvement, respectively. Fifty six and 46% were positive for p53 and p27, respectively. No association between the expression of both genes and gender, degree of differentiation, lymph node or blood vessel involvement, was observed. Overall five years actuarial survival was 32%. Patients with positive or negative p53 expression had a 22% and 53% survival, respectively (p=0.05). No association between survival and p27 expression was observed.
p53 gene expression is a prognostic factor for subserosal gallbladder cancer.</abstract><cop>Chile</cop><pmid>19915764</pmid><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Biomarkers, Tumor - genetics Blood vessels Carcinoma Carcinoma - genetics Carcinoma - mortality Carcinoma - pathology Cyclin-Dependent Kinase Inhibitor p27 - genetics Differentiation Female Gallbladder Gallbladder Neoplasms - genetics Gallbladder Neoplasms - mortality Gallbladder Neoplasms - pathology Humans Immunohistochemistry Lymph nodes Male Middle Aged p27 gene p53 protein Prognosis Serous Membrane - pathology Survival Tumor Suppressor Protein p53 - genetics Tumors |
| title | p53 and p27 gene expression in subserosal gallbladder carcinoma |
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