Impact of overweight on clinical outcomes in patients undergoing coronary revascularization
To determine the impact of BMI on clinical outcome in patients with heart failure underwent coronary revascularization. The DESIRE-plus (Drug-Eluting Stent Impact on Revascularization-plus) was a single-center registry of coronary revascularization in our institution between July 1, 2004 and Septemb...
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| Veröffentlicht in: | Zhong hua yi xue za zhi 2010-05, Vol.90 (20), p.1381-1384 |
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| creator | Kang, Jun-ping Ma, Chang-sheng Lü, Qiang Nie, Shao-ping Liu, Xin-min Liu, Xiao-hui DU, Xin Hu, Rong Dong, Jian-zeng Chen, Fang Lü, Shu-zheng Gu, Cheng-xiong Huang, Fang-jiong Wu, Xue-si |
| description | To determine the impact of BMI on clinical outcome in patients with heart failure underwent coronary revascularization.
The DESIRE-plus (Drug-Eluting Stent Impact on Revascularization-plus) was a single-center registry of coronary revascularization in our institution between July 1, 2004 and September 30, 2005. We analyzed heart failure patients with the complete data of body mass index (BMI) data from the DESIRE-plus trial and grouped them by BMI (normal BMI group, BMI < 24; overweight group, BMI 24-27.9; obesity group, BMI > or = 28). Total mortality, cardiac mortality and MACCE including death, neo-myocardial infarction, stroke, re-revascularization were recorded. We evaluated risk estimates for three bodyweight groups.
1010 patients were included in the study (295 in normal BMI group; 495 in overweight group and 220 obesity group). Median follow-up was 542 days. Overweight and obese patients were younger (59.3 +/- 10.14 years, 58.6 +/- 10.30 years vs 62.6 +/- 9.93 years, P < 0.01) and had a significantly higher incidence of hypertension (61.2, 66.8% vs 52.5%, P = 0.017), stable angina pectoris (21.2%, 23.7% vs 17.0%, P = 0.05) and higher triglyceride [(1.90 +/- 1.05) mmol/L, (2.10 +/- 1.12) mmol/L vs (1.48 +/- 0.92) mmol/L, P < 0.01)], fasting blood glucose level [(6.07 +/- 2.09) mmol/L, (5.96 +/- 1.53) mmol/L vs (5.67 +/- 1.92) mmol/L, P = 0.021), blood creatinine (84.9 +/- 21.7) micromol/L, (90.2 +/- 30.9) micromol/L vs (82.2 +/- 25.8) micromol/L, P = 0.002] compared with normal BMI patients. Multivariate Cox regression model showed obese patients had an decreased hazard risk (HR) for total mortality (0.285, 95%CI 0.104 - 0.777) and MACCE (0.596, 95%CI 0.401 - 0.885) compared with those for patients with normal BMI, overweight patients had no increased risk for total mortality (HR 0.769, 95%CI 0.442 - 1.338) and MACCE (0.998, 95%CI 0.754 - 1.322), there was hardly any significantly difference in cardiac mortality between three groups (P = 0.223).
There were more risk factors in heart failure patients with coronary heart disease complicated with obesity or overweight, but the prognosis after revascularization of them is at least no worse than the normal weight coronary heart disease patients. |
| doi_str_mv | 10.3760/cma.j.issn.0376-2491.2010.20.006 |
| format | Article |
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The DESIRE-plus (Drug-Eluting Stent Impact on Revascularization-plus) was a single-center registry of coronary revascularization in our institution between July 1, 2004 and September 30, 2005. We analyzed heart failure patients with the complete data of body mass index (BMI) data from the DESIRE-plus trial and grouped them by BMI (normal BMI group, BMI < 24; overweight group, BMI 24-27.9; obesity group, BMI > or = 28). Total mortality, cardiac mortality and MACCE including death, neo-myocardial infarction, stroke, re-revascularization were recorded. We evaluated risk estimates for three bodyweight groups.
1010 patients were included in the study (295 in normal BMI group; 495 in overweight group and 220 obesity group). Median follow-up was 542 days. Overweight and obese patients were younger (59.3 +/- 10.14 years, 58.6 +/- 10.30 years vs 62.6 +/- 9.93 years, P < 0.01) and had a significantly higher incidence of hypertension (61.2, 66.8% vs 52.5%, P = 0.017), stable angina pectoris (21.2%, 23.7% vs 17.0%, P = 0.05) and higher triglyceride [(1.90 +/- 1.05) mmol/L, (2.10 +/- 1.12) mmol/L vs (1.48 +/- 0.92) mmol/L, P < 0.01)], fasting blood glucose level [(6.07 +/- 2.09) mmol/L, (5.96 +/- 1.53) mmol/L vs (5.67 +/- 1.92) mmol/L, P = 0.021), blood creatinine (84.9 +/- 21.7) micromol/L, (90.2 +/- 30.9) micromol/L vs (82.2 +/- 25.8) micromol/L, P = 0.002] compared with normal BMI patients. Multivariate Cox regression model showed obese patients had an decreased hazard risk (HR) for total mortality (0.285, 95%CI 0.104 - 0.777) and MACCE (0.596, 95%CI 0.401 - 0.885) compared with those for patients with normal BMI, overweight patients had no increased risk for total mortality (HR 0.769, 95%CI 0.442 - 1.338) and MACCE (0.998, 95%CI 0.754 - 1.322), there was hardly any significantly difference in cardiac mortality between three groups (P = 0.223).
There were more risk factors in heart failure patients with coronary heart disease complicated with obesity or overweight, but the prognosis after revascularization of them is at least no worse than the normal weight coronary heart disease patients.</description><identifier>ISSN: 0376-2491</identifier><identifier>DOI: 10.3760/cma.j.issn.0376-2491.2010.20.006</identifier><identifier>PMID: 20646625</identifier><language>chi</language><publisher>China</publisher><subject>Aged ; Angioplasty, Balloon, Coronary ; Body Mass Index ; Drug-Eluting Stents ; Female ; Heart Failure - complications ; Heart Failure - diagnosis ; Heart Failure - physiopathology ; Humans ; Male ; Middle Aged ; Obesity - complications ; Overweight - complications ; Prognosis ; Risk Factors</subject><ispartof>Zhong hua yi xue za zhi, 2010-05, Vol.90 (20), p.1381-1384</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20646625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Jun-ping</creatorcontrib><creatorcontrib>Ma, Chang-sheng</creatorcontrib><creatorcontrib>Lü, Qiang</creatorcontrib><creatorcontrib>Nie, Shao-ping</creatorcontrib><creatorcontrib>Liu, Xin-min</creatorcontrib><creatorcontrib>Liu, Xiao-hui</creatorcontrib><creatorcontrib>DU, Xin</creatorcontrib><creatorcontrib>Hu, Rong</creatorcontrib><creatorcontrib>Dong, Jian-zeng</creatorcontrib><creatorcontrib>Chen, Fang</creatorcontrib><creatorcontrib>Lü, Shu-zheng</creatorcontrib><creatorcontrib>Gu, Cheng-xiong</creatorcontrib><creatorcontrib>Huang, Fang-jiong</creatorcontrib><creatorcontrib>Wu, Xue-si</creatorcontrib><title>Impact of overweight on clinical outcomes in patients undergoing coronary revascularization</title><title>Zhong hua yi xue za zhi</title><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><description>To determine the impact of BMI on clinical outcome in patients with heart failure underwent coronary revascularization.
The DESIRE-plus (Drug-Eluting Stent Impact on Revascularization-plus) was a single-center registry of coronary revascularization in our institution between July 1, 2004 and September 30, 2005. We analyzed heart failure patients with the complete data of body mass index (BMI) data from the DESIRE-plus trial and grouped them by BMI (normal BMI group, BMI < 24; overweight group, BMI 24-27.9; obesity group, BMI > or = 28). Total mortality, cardiac mortality and MACCE including death, neo-myocardial infarction, stroke, re-revascularization were recorded. We evaluated risk estimates for three bodyweight groups.
1010 patients were included in the study (295 in normal BMI group; 495 in overweight group and 220 obesity group). Median follow-up was 542 days. Overweight and obese patients were younger (59.3 +/- 10.14 years, 58.6 +/- 10.30 years vs 62.6 +/- 9.93 years, P < 0.01) and had a significantly higher incidence of hypertension (61.2, 66.8% vs 52.5%, P = 0.017), stable angina pectoris (21.2%, 23.7% vs 17.0%, P = 0.05) and higher triglyceride [(1.90 +/- 1.05) mmol/L, (2.10 +/- 1.12) mmol/L vs (1.48 +/- 0.92) mmol/L, P < 0.01)], fasting blood glucose level [(6.07 +/- 2.09) mmol/L, (5.96 +/- 1.53) mmol/L vs (5.67 +/- 1.92) mmol/L, P = 0.021), blood creatinine (84.9 +/- 21.7) micromol/L, (90.2 +/- 30.9) micromol/L vs (82.2 +/- 25.8) micromol/L, P = 0.002] compared with normal BMI patients. Multivariate Cox regression model showed obese patients had an decreased hazard risk (HR) for total mortality (0.285, 95%CI 0.104 - 0.777) and MACCE (0.596, 95%CI 0.401 - 0.885) compared with those for patients with normal BMI, overweight patients had no increased risk for total mortality (HR 0.769, 95%CI 0.442 - 1.338) and MACCE (0.998, 95%CI 0.754 - 1.322), there was hardly any significantly difference in cardiac mortality between three groups (P = 0.223).
There were more risk factors in heart failure patients with coronary heart disease complicated with obesity or overweight, but the prognosis after revascularization of them is at least no worse than the normal weight coronary heart disease patients.</description><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary</subject><subject>Body Mass Index</subject><subject>Drug-Eluting Stents</subject><subject>Female</subject><subject>Heart Failure - complications</subject><subject>Heart Failure - diagnosis</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Overweight - complications</subject><subject>Prognosis</subject><subject>Risk Factors</subject><issn>0376-2491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRb0A0ar0F5B3sEnwIw9niSoelSqxgRWLaOJMilFiBzspgq_HiMJqNHeORkeXkCvOUlkW7FoPkL6lJgSbshgkIqt4Klg8C5YyVpyQ5X--IOsQTMOyUlaCCX5GFoIVWVGIfEletsMIeqKuo-6A_gPN_jVulureWKOhp26etBswUGPpCJNBOwU62xb93hm7p9p5Z8F_Uo8HCHruwZuvyDl7Tk476AOuj3NFnu9unzYPye7xfru52SUjr_IpwegFoJpSQtdC0ygmG2xbgKgrNeskKJQqq_ISZC47jkXJOhS6UkoqXnG5Ipe_f0fv3mcMUz2YoLHvwaKbQ13KjMVqxA95cSTnZsC2Hr0Zonr914f8BponZ-s</recordid><startdate>20100525</startdate><enddate>20100525</enddate><creator>Kang, Jun-ping</creator><creator>Ma, Chang-sheng</creator><creator>Lü, Qiang</creator><creator>Nie, Shao-ping</creator><creator>Liu, Xin-min</creator><creator>Liu, Xiao-hui</creator><creator>DU, Xin</creator><creator>Hu, Rong</creator><creator>Dong, Jian-zeng</creator><creator>Chen, Fang</creator><creator>Lü, Shu-zheng</creator><creator>Gu, Cheng-xiong</creator><creator>Huang, Fang-jiong</creator><creator>Wu, Xue-si</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20100525</creationdate><title>Impact of overweight on clinical outcomes in patients undergoing coronary revascularization</title><author>Kang, Jun-ping ; Ma, Chang-sheng ; Lü, Qiang ; Nie, Shao-ping ; Liu, Xin-min ; Liu, Xiao-hui ; DU, Xin ; Hu, Rong ; Dong, Jian-zeng ; Chen, Fang ; Lü, Shu-zheng ; Gu, Cheng-xiong ; Huang, Fang-jiong ; Wu, Xue-si</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p195t-e739aa8b73afdabb803beddaa3923c0f3a8e384957a353f1e670fe2c988381913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary</topic><topic>Body Mass Index</topic><topic>Drug-Eluting Stents</topic><topic>Female</topic><topic>Heart Failure - complications</topic><topic>Heart Failure - diagnosis</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Overweight - complications</topic><topic>Prognosis</topic><topic>Risk Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Kang, Jun-ping</creatorcontrib><creatorcontrib>Ma, Chang-sheng</creatorcontrib><creatorcontrib>Lü, Qiang</creatorcontrib><creatorcontrib>Nie, Shao-ping</creatorcontrib><creatorcontrib>Liu, Xin-min</creatorcontrib><creatorcontrib>Liu, Xiao-hui</creatorcontrib><creatorcontrib>DU, Xin</creatorcontrib><creatorcontrib>Hu, Rong</creatorcontrib><creatorcontrib>Dong, Jian-zeng</creatorcontrib><creatorcontrib>Chen, Fang</creatorcontrib><creatorcontrib>Lü, Shu-zheng</creatorcontrib><creatorcontrib>Gu, Cheng-xiong</creatorcontrib><creatorcontrib>Huang, Fang-jiong</creatorcontrib><creatorcontrib>Wu, Xue-si</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong hua yi xue za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Jun-ping</au><au>Ma, Chang-sheng</au><au>Lü, Qiang</au><au>Nie, Shao-ping</au><au>Liu, Xin-min</au><au>Liu, Xiao-hui</au><au>DU, Xin</au><au>Hu, Rong</au><au>Dong, Jian-zeng</au><au>Chen, Fang</au><au>Lü, Shu-zheng</au><au>Gu, Cheng-xiong</au><au>Huang, Fang-jiong</au><au>Wu, Xue-si</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of overweight on clinical outcomes in patients undergoing coronary revascularization</atitle><jtitle>Zhong hua yi xue za zhi</jtitle><addtitle>Zhonghua Yi Xue Za Zhi</addtitle><date>2010-05-25</date><risdate>2010</risdate><volume>90</volume><issue>20</issue><spage>1381</spage><epage>1384</epage><pages>1381-1384</pages><issn>0376-2491</issn><abstract>To determine the impact of BMI on clinical outcome in patients with heart failure underwent coronary revascularization.
The DESIRE-plus (Drug-Eluting Stent Impact on Revascularization-plus) was a single-center registry of coronary revascularization in our institution between July 1, 2004 and September 30, 2005. We analyzed heart failure patients with the complete data of body mass index (BMI) data from the DESIRE-plus trial and grouped them by BMI (normal BMI group, BMI < 24; overweight group, BMI 24-27.9; obesity group, BMI > or = 28). Total mortality, cardiac mortality and MACCE including death, neo-myocardial infarction, stroke, re-revascularization were recorded. We evaluated risk estimates for three bodyweight groups.
1010 patients were included in the study (295 in normal BMI group; 495 in overweight group and 220 obesity group). Median follow-up was 542 days. Overweight and obese patients were younger (59.3 +/- 10.14 years, 58.6 +/- 10.30 years vs 62.6 +/- 9.93 years, P < 0.01) and had a significantly higher incidence of hypertension (61.2, 66.8% vs 52.5%, P = 0.017), stable angina pectoris (21.2%, 23.7% vs 17.0%, P = 0.05) and higher triglyceride [(1.90 +/- 1.05) mmol/L, (2.10 +/- 1.12) mmol/L vs (1.48 +/- 0.92) mmol/L, P < 0.01)], fasting blood glucose level [(6.07 +/- 2.09) mmol/L, (5.96 +/- 1.53) mmol/L vs (5.67 +/- 1.92) mmol/L, P = 0.021), blood creatinine (84.9 +/- 21.7) micromol/L, (90.2 +/- 30.9) micromol/L vs (82.2 +/- 25.8) micromol/L, P = 0.002] compared with normal BMI patients. Multivariate Cox regression model showed obese patients had an decreased hazard risk (HR) for total mortality (0.285, 95%CI 0.104 - 0.777) and MACCE (0.596, 95%CI 0.401 - 0.885) compared with those for patients with normal BMI, overweight patients had no increased risk for total mortality (HR 0.769, 95%CI 0.442 - 1.338) and MACCE (0.998, 95%CI 0.754 - 1.322), there was hardly any significantly difference in cardiac mortality between three groups (P = 0.223).
There were more risk factors in heart failure patients with coronary heart disease complicated with obesity or overweight, but the prognosis after revascularization of them is at least no worse than the normal weight coronary heart disease patients.</abstract><cop>China</cop><pmid>20646625</pmid><doi>10.3760/cma.j.issn.0376-2491.2010.20.006</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Angioplasty, Balloon, Coronary Body Mass Index Drug-Eluting Stents Female Heart Failure - complications Heart Failure - diagnosis Heart Failure - physiopathology Humans Male Middle Aged Obesity - complications Overweight - complications Prognosis Risk Factors |
| title | Impact of overweight on clinical outcomes in patients undergoing coronary revascularization |
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