Role of VPAC1 and VPAC2 in VIP mediated inhibition of rat pulmonary artery and aortic smooth muscle cell proliferation

Recent studies have suggested the potential use of vasoactive intestinal peptide (VIP) in the treatment of pulmonary arterial hypertension (PAH). An understanding of the mechanism of action of VIP is important for the development of new therapies for PAH. The biological effects of VIP are mediated b...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2010-08, Vol.31 (8), p.1517-1522
Hauptverfasser:	St. Hilaire, Rose-Claire, Murthy, Subramanyam N., Kadowitz, Philip J., Jeter, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Aorta - cytology Aorta - metabolism Arteries Biological and medical sciences Blotting, Western Cell Proliferation - drug effects Cells, Cultured Cyclic AMP - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - physiopathology Immunohistochemistry Inhibition Male Muscles Myocytes, Smooth Muscle - physiology Nucleotides Peptide Fragments - pharmacology Peptides Polyallylamine hydrochloride Proliferation Pulmonary Artery - cytology Pulmonary Artery - metabolism Rats Rats, Sprague-Dawley Receptors Receptors, Vasoactive Intestinal Peptide, Type II - antagonists & inhibitors Receptors, Vasoactive Intestinal Peptide, Type II - genetics Receptors, Vasoactive Intestinal Peptide, Type II - physiology Receptors, Vasoactive Intestinal Polypeptide, Type I - antagonists & inhibitors Receptors, Vasoactive Intestinal Polypeptide, Type I - genetics Receptors, Vasoactive Intestinal Polypeptide, Type I - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Vasoactive intestinal peptide Vasoactive Intestinal Peptide - physiology Vertebrates: endocrinology VPAC1 VPAC2
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