Dysregulation of p53/Sp1 Control Leads to DNA Methyltransferase-1 Overexpression in Lung Cancer

Overexpression of DNA 5'-cytosine-methyltransferases (DNMT), which are enzymes that methylate the cytosine residue of CpGs, is involved in many cancers. However, the mechanism of DNMT overexpression remains unclear. Here, we showed that wild-type p53 negatively regulated DNMT1 expression by for...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-07, Vol.70 (14), p.5807-5817
Hauptverfasser:	LIN, Ruo-Kai, WU, Chiu-Yi, WANG, Yi-Ching, CHANG, Jer-Wei, JUAN, Li-Jung, HSU, Han-Shui, CHEN, Chih-Yi, LU, Yun-Yueh, TANG, Yen-An, YANG, Yi-Chieh, YANG, Pan-Chyr
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - metabolism Antineoplastic agents Binding Sites Biological and medical sciences Cell Line, Tumor DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - biosynthesis DNA (Cytosine-5-)-Methyltransferases - genetics Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Immunoprecipitation Lung Neoplasms - enzymology Lung Neoplasms - genetics Medical sciences Pharmacology. Drug treatments Pneumology Point Mutation Promoter Regions, Genetic Proto-Oncogene Proteins c-mdm2 - metabolism Sp1 Transcription Factor - genetics Sp1 Transcription Factor - metabolism Transcription, Genetic Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Tumors of the respiratory system and mediastinum Ubiquitination
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!