Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channels

OBJECTIVEThe increased mortality observed with the cholesteryl ester transfer protein inhibitor torcetrapib is partly due to increased aldosterone production and blood pressure. The mechanisms underlying these effects were investigated. METHODSCytochrome P450 subunit 11B2 (aldosterone synthase), ext...

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Veröffentlicht in:	Journal of hypertension 2010-08, Vol.28 (8), p.1676-1686
Hauptverfasser:	Clerc, Roger G, Stauffer, Andrea, Weibel, Franziska, Hainaut, Emmanuelle, Perez, Anne, Hoflack, Jean-Christophe, Bénardeau, Agnès, Pflieger, Philippe, Garriz, Jose MR, Funder, John W, Capponi, Alessandro M, Niesor, Eric J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex - drug effects Adrenal Cortex - metabolism Adrenal Cortex - pathology Adrenal Gland Neoplasms Aldosterone - metabolism Angiotensin II - pharmacology Animals Anticholesteremic Agents - pharmacology Antihypertensive agents Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Calcium - metabolism Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - metabolism Cardiology. Vascular system Cardiovascular system Cell Line, Tumor Cholesterol Ester Transfer Proteins - antagonists & inhibitors Cytochrome P-450 CYP11B2 - biosynthesis Cytochrome P-450 CYP11B2 - genetics Cytosol - drug effects Cytosol - metabolism Enzyme Induction - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression - drug effects Gene Expression Profiling Humans Hypertension - drug therapy Medical sciences NAV1.1 Voltage-Gated Sodium Channel Nerve Tissue Proteins - metabolism Pharmacology. Drug treatments Quinolines - pharmacology Rats Rats, Inbred SHR RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Sodium Channels - metabolism Structure-Activity Relationship Sulfhydryl Compounds - pharmacology
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