Pantoprazole Does Not Influence the Antiplatelet Effect of Clopidogrel-A Whole Blood Aggregometry Study After Coronary Stenting

Recent attention has been drawn to a potential drug-drug interaction observed between clopidogrel and proton pump inhibitors (PPIs). However, this potential interaction may not be a class effect of PPIs. We investigated if pantoprazole, which has a different metabolism than omeprazole, diminishes th...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2010-07, Vol.56 (1), p.91-97
Hauptverfasser:	Neubauer, Horst, Engelhardt, Andreas, Krüger, Jan C, Lask, Sebastian, Börgel, Jan, Mügge, Andreas, Endres, Heinz G
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinylmethylsulfinylbenzimidazoles - metabolism 2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology Aged Angioplasty, Balloon, Coronary - methods Aspirin - therapeutic use Coronary Artery Disease - therapy Drug Interactions Esomeprazole Female Humans Male Middle Aged Multivariate Analysis Omeprazole - metabolism Omeprazole - pharmacology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - metabolism Platelet Aggregation Inhibitors - pharmacology Platelet Function Tests Prospective Studies Proton Pump Inhibitors - metabolism Proton Pump Inhibitors - pharmacology Regression Analysis Stents Ticlopidine - analogs & derivatives Ticlopidine - metabolism Ticlopidine - pharmacology
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