Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program
Background Changes in myocardial blood flow between rest and stress states are commonly used to diagnose coronary artery disease. Relative myocardial perfusion imaging (MPI) is used routinely while myocardial blood flow quantification (MBF) may improve the sensitivity for detection of early disease....
Gespeichert in:
| Veröffentlicht in: | Journal of nuclear cardiology 2010-08, Vol.17 (4), p.600-616 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 616 |
|---|---|
| container_issue | 4 |
| container_start_page | 600 |
| container_title | Journal of nuclear cardiology |
| container_volume | 17 |
| creator | Klein, Ran Renaud, Jennifer M. Ziadi, Maria C. Thorn, Stephanie L. Adler, Andy Beanlands, Rob S. deKemp, Robert A. |
| description | Background
Changes in myocardial blood flow between rest and stress states are commonly used to diagnose coronary artery disease. Relative myocardial perfusion imaging (MPI) is used routinely while myocardial blood flow quantification (MBF) may improve the sensitivity for detection of early disease. The ratio of flow at stress and rest (S/R) and their difference (S-R) have both been proposed as a means to detect regions with reduced myocardial flow reserve (MFR). In this study, we describe a highly automated method to calculate regional and global rest, stress, S/R, and S-R polar maps of the left ventricle myocardium.
Methods
We measured the inter- and intra-operator variability using two randomized datasets (n = 30 each) for each of two operators (novice and expert) with correlation and Bland-Altman reproducibility coefficient (RPC%) analyses.
Results
S-R MBF had less inter-operator dependent variability than S/R (RPC% = 5.0% vs 12.6%,
P
|
| doi_str_mv | 10.1007/s12350-010-9225-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733995609</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2091576681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-57e43cff5c35bb980c1d7aedb93e46ec98498a20f32a312b97b4c4cd029c027b3</originalsourceid><addsrcrecordid>eNp1kc1u1TAQhS0EouXCA7BBFhtWBv_E1_ESVfxUqsQG1tHYmdy6SuJgO6A8UV8T995SEBIrWzPfOTOaQ8hLwd8Kzs27LKTSnHHBmZVSM_WInAutJNtrLR7XPzeCKd2KM_Is5xvOuVXWPiVnkqvWCKXPye3lXBIwCnNPw1wwsbhgghITTbggFHBhDGWjcaDTFj2kPsBI3RhjT4cx_jwq_-ocawkzph9IJ4S8JpxwLpmuOcwHmlYX-rBOrJV0wXKUA70Oh-txo7CWOEHBWpph3HLIdEnxkGB6Tp4MMGZ8cf_uyLePH75efGZXXz5dXry_Yr5R-8K0wUb5YdBeaedsy73oDWDvrMJmj962jW1B8kFJUEI6a1zjG99zaT2XxqkdeXPyrXO_r5hLN4XscRxhxrjmzqh6Qb2vh9yR1_-QN3FNde0KcaPrOtxUSJwgn2LOCYduSWGCtHWCd3cZdqcMu5phd5dhp6rm1b3x6ibsHxS_Q6uAPAG5tuYDpj-T_-_6CxAZqno</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>707543607</pqid></control><display><type>article</type><title>Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Klein, Ran ; Renaud, Jennifer M. ; Ziadi, Maria C. ; Thorn, Stephanie L. ; Adler, Andy ; Beanlands, Rob S. ; deKemp, Robert A.</creator><creatorcontrib>Klein, Ran ; Renaud, Jennifer M. ; Ziadi, Maria C. ; Thorn, Stephanie L. ; Adler, Andy ; Beanlands, Rob S. ; deKemp, Robert A.</creatorcontrib><description>Background
Changes in myocardial blood flow between rest and stress states are commonly used to diagnose coronary artery disease. Relative myocardial perfusion imaging (MPI) is used routinely while myocardial blood flow quantification (MBF) may improve the sensitivity for detection of early disease. The ratio of flow at stress and rest (S/R) and their difference (S-R) have both been proposed as a means to detect regions with reduced myocardial flow reserve (MFR). In this study, we describe a highly automated method to calculate regional and global rest, stress, S/R, and S-R polar maps of the left ventricle myocardium.
Methods
We measured the inter- and intra-operator variability using two randomized datasets (n = 30 each) for each of two operators (novice and expert) with correlation and Bland-Altman reproducibility coefficient (RPC%) analyses.
Results
S-R MBF had less inter-operator dependent variability than S/R (RPC% = 5.0% vs 12.6%,
P
< .001). While there was no difference in intra-operator variability with S-R MBF (novice vs expert RPC% = 6.4% vs 5.9%,
P
= ns), variability was higher in the novice-operator for S/R (RPC% = 16.8% vs 8.5% respectively,
P
< .001), suggesting that S-R may be preferred for detecting small changes in MFR. The novice operator’s intervention pattern became more similar to that of the expert in the later dataset, emphasizing the need for adequate training and quality assurance.
Conclusion
The proposed method results in low operator-dependent variability, suitable for routine use.</description><identifier>ISSN: 1071-3581</identifier><identifier>EISSN: 1532-6551</identifier><identifier>DOI: 10.1007/s12350-010-9225-3</identifier><identifier>PMID: 20387135</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Aged ; Cardiology ; Coronary Artery Disease - diagnostic imaging ; Female ; Fractional Flow Reserve, Myocardial ; Humans ; Image Interpretation, Computer-Assisted - methods ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Myocardial Perfusion Imaging - methods ; Nuclear Medicine ; Observer Variation ; Original Article ; Radiology ; Radiopharmaceuticals ; Reproducibility of Results ; Rubidium Radioisotopes ; Sensitivity and Specificity</subject><ispartof>Journal of nuclear cardiology, 2010-08, Vol.17 (4), p.600-616</ispartof><rights>American Society of Nuclear Cardiology 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-57e43cff5c35bb980c1d7aedb93e46ec98498a20f32a312b97b4c4cd029c027b3</citedby><cites>FETCH-LOGICAL-c436t-57e43cff5c35bb980c1d7aedb93e46ec98498a20f32a312b97b4c4cd029c027b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12350-010-9225-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12350-010-9225-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20387135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klein, Ran</creatorcontrib><creatorcontrib>Renaud, Jennifer M.</creatorcontrib><creatorcontrib>Ziadi, Maria C.</creatorcontrib><creatorcontrib>Thorn, Stephanie L.</creatorcontrib><creatorcontrib>Adler, Andy</creatorcontrib><creatorcontrib>Beanlands, Rob S.</creatorcontrib><creatorcontrib>deKemp, Robert A.</creatorcontrib><title>Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program</title><title>Journal of nuclear cardiology</title><addtitle>J. Nucl. Cardiol</addtitle><addtitle>J Nucl Cardiol</addtitle><description>Background
Changes in myocardial blood flow between rest and stress states are commonly used to diagnose coronary artery disease. Relative myocardial perfusion imaging (MPI) is used routinely while myocardial blood flow quantification (MBF) may improve the sensitivity for detection of early disease. The ratio of flow at stress and rest (S/R) and their difference (S-R) have both been proposed as a means to detect regions with reduced myocardial flow reserve (MFR). In this study, we describe a highly automated method to calculate regional and global rest, stress, S/R, and S-R polar maps of the left ventricle myocardium.
Methods
We measured the inter- and intra-operator variability using two randomized datasets (n = 30 each) for each of two operators (novice and expert) with correlation and Bland-Altman reproducibility coefficient (RPC%) analyses.
Results
S-R MBF had less inter-operator dependent variability than S/R (RPC% = 5.0% vs 12.6%,
P
< .001). While there was no difference in intra-operator variability with S-R MBF (novice vs expert RPC% = 6.4% vs 5.9%,
P
= ns), variability was higher in the novice-operator for S/R (RPC% = 16.8% vs 8.5% respectively,
P
< .001), suggesting that S-R may be preferred for detecting small changes in MFR. The novice operator’s intervention pattern became more similar to that of the expert in the later dataset, emphasizing the need for adequate training and quality assurance.
Conclusion
The proposed method results in low operator-dependent variability, suitable for routine use.</description><subject>Aged</subject><subject>Cardiology</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Female</subject><subject>Fractional Flow Reserve, Myocardial</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Myocardial Perfusion Imaging - methods</subject><subject>Nuclear Medicine</subject><subject>Observer Variation</subject><subject>Original Article</subject><subject>Radiology</subject><subject>Radiopharmaceuticals</subject><subject>Reproducibility of Results</subject><subject>Rubidium Radioisotopes</subject><subject>Sensitivity and Specificity</subject><issn>1071-3581</issn><issn>1532-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc1u1TAQhS0EouXCA7BBFhtWBv_E1_ESVfxUqsQG1tHYmdy6SuJgO6A8UV8T995SEBIrWzPfOTOaQ8hLwd8Kzs27LKTSnHHBmZVSM_WInAutJNtrLR7XPzeCKd2KM_Is5xvOuVXWPiVnkqvWCKXPye3lXBIwCnNPw1wwsbhgghITTbggFHBhDGWjcaDTFj2kPsBI3RhjT4cx_jwq_-ocawkzph9IJ4S8JpxwLpmuOcwHmlYX-rBOrJV0wXKUA70Oh-txo7CWOEHBWpph3HLIdEnxkGB6Tp4MMGZ8cf_uyLePH75efGZXXz5dXry_Yr5R-8K0wUb5YdBeaedsy73oDWDvrMJmj962jW1B8kFJUEI6a1zjG99zaT2XxqkdeXPyrXO_r5hLN4XscRxhxrjmzqh6Qb2vh9yR1_-QN3FNde0KcaPrOtxUSJwgn2LOCYduSWGCtHWCd3cZdqcMu5phd5dhp6rm1b3x6ibsHxS_Q6uAPAG5tuYDpj-T_-_6CxAZqno</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Klein, Ran</creator><creator>Renaud, Jennifer M.</creator><creator>Ziadi, Maria C.</creator><creator>Thorn, Stephanie L.</creator><creator>Adler, Andy</creator><creator>Beanlands, Rob S.</creator><creator>deKemp, Robert A.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program</title><author>Klein, Ran ; Renaud, Jennifer M. ; Ziadi, Maria C. ; Thorn, Stephanie L. ; Adler, Andy ; Beanlands, Rob S. ; deKemp, Robert A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-57e43cff5c35bb980c1d7aedb93e46ec98498a20f32a312b97b4c4cd029c027b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Cardiology</topic><topic>Coronary Artery Disease - diagnostic imaging</topic><topic>Female</topic><topic>Fractional Flow Reserve, Myocardial</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Myocardial Perfusion Imaging - methods</topic><topic>Nuclear Medicine</topic><topic>Observer Variation</topic><topic>Original Article</topic><topic>Radiology</topic><topic>Radiopharmaceuticals</topic><topic>Reproducibility of Results</topic><topic>Rubidium Radioisotopes</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klein, Ran</creatorcontrib><creatorcontrib>Renaud, Jennifer M.</creatorcontrib><creatorcontrib>Ziadi, Maria C.</creatorcontrib><creatorcontrib>Thorn, Stephanie L.</creatorcontrib><creatorcontrib>Adler, Andy</creatorcontrib><creatorcontrib>Beanlands, Rob S.</creatorcontrib><creatorcontrib>deKemp, Robert A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of nuclear cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klein, Ran</au><au>Renaud, Jennifer M.</au><au>Ziadi, Maria C.</au><au>Thorn, Stephanie L.</au><au>Adler, Andy</au><au>Beanlands, Rob S.</au><au>deKemp, Robert A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program</atitle><jtitle>Journal of nuclear cardiology</jtitle><stitle>J. Nucl. Cardiol</stitle><addtitle>J Nucl Cardiol</addtitle><date>2010-08-01</date><risdate>2010</risdate><volume>17</volume><issue>4</issue><spage>600</spage><epage>616</epage><pages>600-616</pages><issn>1071-3581</issn><eissn>1532-6551</eissn><abstract>Background
Changes in myocardial blood flow between rest and stress states are commonly used to diagnose coronary artery disease. Relative myocardial perfusion imaging (MPI) is used routinely while myocardial blood flow quantification (MBF) may improve the sensitivity for detection of early disease. The ratio of flow at stress and rest (S/R) and their difference (S-R) have both been proposed as a means to detect regions with reduced myocardial flow reserve (MFR). In this study, we describe a highly automated method to calculate regional and global rest, stress, S/R, and S-R polar maps of the left ventricle myocardium.
Methods
We measured the inter- and intra-operator variability using two randomized datasets (n = 30 each) for each of two operators (novice and expert) with correlation and Bland-Altman reproducibility coefficient (RPC%) analyses.
Results
S-R MBF had less inter-operator dependent variability than S/R (RPC% = 5.0% vs 12.6%,
P
< .001). While there was no difference in intra-operator variability with S-R MBF (novice vs expert RPC% = 6.4% vs 5.9%,
P
= ns), variability was higher in the novice-operator for S/R (RPC% = 16.8% vs 8.5% respectively,
P
< .001), suggesting that S-R may be preferred for detecting small changes in MFR. The novice operator’s intervention pattern became more similar to that of the expert in the later dataset, emphasizing the need for adequate training and quality assurance.
Conclusion
The proposed method results in low operator-dependent variability, suitable for routine use.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>20387135</pmid><doi>10.1007/s12350-010-9225-3</doi><tpages>17</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1071-3581 |
| ispartof | Journal of nuclear cardiology, 2010-08, Vol.17 (4), p.600-616 |
| issn | 1071-3581 1532-6551 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733995609 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Aged Cardiology Coronary Artery Disease - diagnostic imaging Female Fractional Flow Reserve, Myocardial Humans Image Interpretation, Computer-Assisted - methods Imaging Male Medicine Medicine & Public Health Myocardial Perfusion Imaging - methods Nuclear Medicine Observer Variation Original Article Radiology Radiopharmaceuticals Reproducibility of Results Rubidium Radioisotopes Sensitivity and Specificity |
| title | Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T07%3A10%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intra-%20and%20inter-operator%20repeatability%20of%20myocardial%20blood%20flow%20and%20myocardial%20flow%20reserve%20measurements%20using%20rubidium-82%20pet%20and%20a%20highly%20automated%20analysis%20program&rft.jtitle=Journal%20of%20nuclear%20cardiology&rft.au=Klein,%20Ran&rft.date=2010-08-01&rft.volume=17&rft.issue=4&rft.spage=600&rft.epage=616&rft.pages=600-616&rft.issn=1071-3581&rft.eissn=1532-6551&rft_id=info:doi/10.1007/s12350-010-9225-3&rft_dat=%3Cproquest_cross%3E2091576681%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=707543607&rft_id=info:pmid/20387135&rfr_iscdi=true |