Intra- and interspecies interactions between prion proteins and effects of mutations and polymorphisms

Recently, crystallization of the prion protein in a dimeric form was reported. Here we show that native soluble homogeneous FLAG-tagged prion proteins from hamster, man and cattle expressed in the baculovirus system are predominantly dimeric. The PrP/PrP interaction was confirmed in Semliki Forest v...

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Veröffentlicht in:	Biological chemistry 2003-05, Vol.384 (5), p.791-803
Hauptverfasser:	Hundt, Christoph, Gauczynski, Sabine, Leucht, Christoph, Riley, M Louise, Weiss, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified - metabolism Cattle Cell Line Cricetinae Dimerization Humans Mutation - physiology Polymorphism, Single Nucleotide - physiology Protein Structure, Tertiary PrPC Proteins - chemistry PrPC Proteins - genetics PrPC Proteins - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Saccharomyces cerevisiae Proteins - genetics Semliki forest virus - genetics Sheep Species Specificity Transfection Two-Hybrid System Techniques
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