Pravastatin, lipids, and atherosclerosis in the carotid arteries: Design features of a clinical trial with carotid atherosclerosis outcome

The Pravastatin, Lipids, and Atherosclerosis in the Carotids trial (PLAC-II) was initiated in 1987 and is the first double-masked randomized clinical trial with progression of early extracranial carotid atherosclerosis as an outcome variable. The trial will compare a lipid-lowering agent (pravastati...

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Veröffentlicht in:	Controlled clinical trials 1992-12, Vol.13 (6), p.495-506
Hauptverfasser:	Crouse, J.R., Byington, R.P., Bond, M.G., Espeland, M.A., Sprinkle, J.W., McGovern, M., Furberg, C.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Arteriosclerosis - blood Arteriosclerosis - diagnostic imaging Arteriosclerosis - drug therapy atherosclerosis carotid Carotid Arteries - diagnostic imaging Carotid Artery Diseases - blood Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - drug therapy clinical trials Double-Blind Method Female Humans intima-media thickness LDL cholesterol Lipids - blood Male Middle Aged Pravastatin - therapeutic use Reductase inhibitors Research Design Ultrasonography ultrasound
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