Dexamethasone administration inhibits skeletal muscle expression of the androgen receptor and IGF-1 - implications for steroid-induced myopathy

Summary Context  Glucocorticoids are a well‐recognized cause of muscle weakness. The early effects of glucocorticoids on skeletal muscle (SkM) androgen and IGF‐1 pathways have not been previously investigated in human subjects. Objective  To determine if administration of the potent glucocorticoid d...

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Veröffentlicht in:Clinical endocrinology (Oxford) 2010-07, Vol.73 (1), p.126-132
Hauptverfasser: Inder, Warrick J., Jang, Christina, Obeyesekere, Varuni R., Alford, Frank P.
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Sprache:eng
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